Six-year follow-up outcomes of the P(LLA-CL)/Fg bio-patch for anterior vaginal wall prolapse treatment

Wu, Chenghao; Zhang, Zhixia; He, Hongchao; Zhou, Zixuan; Li, Huaifang; Tong, Xiaowen

doi:10.1007/s00192-022-05284-5

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Previous studies have shown its potential in vascular, oesophageal, urethral and vaginal tissue engineering [ 10–17 ]. Electrospun PLCL/fibrinogen mesh for anterior POP surgery has been used in two clinical pilots with potential results [ 18 , 19 ]. However, according to our knowledge, those are the only previously published studies utilizing PLCL for POP tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Promoting cell proliferation and collagen production with ascorbic acid 2-phosphate-releasing poly(l-lactide-co-ε-caprolactone) membranes for treating pelvic organ prolapse

Kurki,

Paakinaho,

Hannula

et al. 2024

Regenerative Biomaterials

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Pelvic organ prolapse (POP) afflicts millions of women globally. In POP, the weakened support of the pelvic floor results in the descent of pelvic organs into the vagina, causing a feeling of bulging, problems in urination, defecation and/or sexual function. However, the existing surgical repair methods for relapsed POP remain insufficient, highlighting the urgent need for more effective alternatives. Collagen is an essential component in pelvic floor tissues providing structural support, and its production is controlled by ascorbic acid. Therefore, we investigated novel ascorbic acid 2-phosphate (A2P) -releasing poly(l-lactide-co-epsilon-caprolactone) (PLCLA2P) membranes in vitro to promote cell proliferation and extracellular matrix protein production to strengthen the natural support of the pelvic fascia for POP applications. We analysed the mechanical properties and the impact of PLCLA2P on cellular responses through cell culture analysis using human vaginal fibroblasts (hVFs) and human adipose-derived stem/stromal cells (hASCs) compared to PLCL. In addition, the A2P release from PLCLA2P membranes was assessed in vitro. The PLCLA2P demonstrated slightly lower tensile strength (2.2 ± 0.4 MPa) compared to PLCL (3.7 ± 0.6 MPa) for the first four weeks in vitro. The A2P was most rapidly released during the first 48 hours of in vitro incubation. Our findings demonstrated significantly increased proliferation and collagen production of both hVFs and hASCs on A2P -releasing PLCLA2P compared to PLCL. In addition, extracellular collagen type I fibres were detected in hVFs, suggesting enhanced collagen maturation on PLCLA2P. Moreover, increased extracellular matrix protein expression was detected on PLCLA2P in both hVFs and hASCs compared to plain PLCL. In conclusion, these findings highlight the potential of PLCLA2P as a promising candidate for promoting tissue regeneration in applications aimed for POP tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Promoting cell proliferation and collagen production with ascorbic acid 2-phosphate-releasing poly(l-lactide-co-ε-caprolactone) membranes for treating pelvic organ prolapse

Kurki,

Paakinaho,

Hannula

et al. 2024

Regenerative Biomaterials

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“…While large amounts of biomaterials were recently investigated for replacing PPM in surgical treatment of POP [ 13–15 ], the therapeutic effect of most biomaterials has not been verified by clinical trials. A few of clinical trials have not even shown good long-term anatomic outcomes in clinical studies [ 16 , 17 ] and parts of them are just in their infancy, lacking further rigorous and high-quality clinical evidences [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Tannic acid-loaded hydrogel coating endues polypropylene mesh with hemostatic and anti-inflammatory capacity for facilitating pelvic floor repair

Zhou²,

You

et al. 2022

Regenerative Biomaterials

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The application of polypropylene mesh (PPM) in pelvic organ prolapse (POP) treatment was severely limited by the complications associated with PPM, such as mesh exposure, chronic inflammatory reactions, and postoperative hematoma. This study applied a method of fabricating a hydrogel-mesh complex (PPM+TA@GelMA) to cross-link tannic acid (TA) directly with Methacrylate Gelatin (GelMA) hydrogel and thus to form a coating for polypropylene mesh. This one-step coating modification improved the hydrophilicity and cyto-compatibility of PPM. The hemostatic effect of PPM+TA@GelMA was confirmed through tail amputation test. Through the defect tissue repair experiments in vivo, it was proved that PPM+TA@GelMA had effects of anti-inflammation and promoting tissue repair, and regulated the M2 subtype macrophages polarization for tissue repair. The TA-loaded hydrogel coating endued PPM with multiple functions. It is believed that the novel hydrogel-mesh complex and its fabrication method will have great significance in basic research and clinical application.

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Erroneous and Incomplete Reporting of the Pelvic Organ Prolapse Quantification System

Younes,

Raoofi,

Carey

2024

Int Urogynecol J

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Six-year follow-up outcomes of the P(LLA-CL)/Fg bio-patch for anterior vaginal wall prolapse treatment

Cited by 4 publications

References 29 publications

Promoting cell proliferation and collagen production with ascorbic acid 2-phosphate-releasing poly(l-lactide-co-ε-caprolactone) membranes for treating pelvic organ prolapse

Promoting cell proliferation and collagen production with ascorbic acid 2-phosphate-releasing poly(l-lactide-co-ε-caprolactone) membranes for treating pelvic organ prolapse

Tannic acid-loaded hydrogel coating endues polypropylene mesh with hemostatic and anti-inflammatory capacity for facilitating pelvic floor repair

Erroneous and Incomplete Reporting of the Pelvic Organ Prolapse Quantification System

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