Six-Year Incidence of and Risk Factors for Cataract Surgery in a Multi-ethnic Asian Population

Tan, Ava Grace; Kifley, Annette; Tham, Yih‐Chung; Shi, Yuan; Chee, Miao Li; Sabanayagam, Charumathi; Tan, Nicholas; Wong, Kevin; Mitchell, Paul; Cumming, Robert; Wong, Tien Yin; Wang, Jie Jin; Cheng, Ching‐Yu

doi:10.1016/j.ophtha.2018.07.026

Cited by 27 publications

(35 citation statements)

References 38 publications

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“…This association was also present in our analysis: persons suffering from diabetes showed a 1.4-fold higher frequency of cataract surgery independently from aging. Our risk estimates for undergoing cataract surgery were slightly lower than those from a previous multi-ethnic Asian population from Singapore [39], which might be due to differences in diabetic treatment regime and in blood sugar control between the two countries. Cataract surgery in only one eye within 5 years a b Fig.…”

Section: Discussioncontrasting

confidence: 88%

Frequency of cataract surgery and its impact on visual function—results from the German Gutenberg Health Study

Schuster

Nickels

Pfeiffer

et al. 2020

Graefes Arch Clin Exp Ophthalmol

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Purpose To determine the frequency of cataract surgery in Germany and to evaluate its impact on visual function in an adult population. Methods The population-based Gutenberg Health Study was conducted in Germany with its baseline examination between 2007 and 2012 and a 5-year follow-up examiantion. An ophthalmological examination including slit-lamp examination, ocular biometry, and Scheimpflug imaging was carried out. Overall and age-specific frequencies of unilateral and bilateral cataract surgery within 5 years were computed including the 95% confidential intervals [95%-CI]. Association analyses were conducted to determine social and ocular associated factors using multivariable logistic regression analysis. Vision-related quality of life was assessed using NEI VFQ-25. Results A total of 10,544 people aged 35 to 74 years were bilateral phakic at baseline and had information on lens status at the 5-year examination. Of these, 168 had unilateral cataract surgery (1.6% [1.4–1.9%]), and 448 had bilateral cataract surgery (4.2% [3.9–4.7%]) in the following 5 years. The frequency of cataract surgery increased with age: 45–54-year-old subjects had twice as often cataract surgery (in at least on eye: OR = 2.32) than at age 35–44 years. The frequency further strongly increases with age (55–64 years: OR = 10.5; 65–74 years: OR = 43.8, p < 0.001). Subjects with glaucoma were more likely to have cataract surgery (OR = 2.52, p < 0.001). Visual function increased when undergoing bilateral cataract surgery. Conclusions The frequency of cataract surgery is low at younger ages and increases up to 26% at age 70–74 years. Persons with glaucoma are more likely to undergo cataract surgery at population-based level in Germany.

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Section: Discussioncontrasting

confidence: 88%

Frequency of cataract surgery and its impact on visual function—results from the German Gutenberg Health Study

Schuster

Nickels

Pfeiffer

et al. 2020

Graefes Arch Clin Exp Ophthalmol

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“…Accordingly, the effect of DR on the occurrence of sight-threatening cataract is relative accuracy compared to previous studies which enrolled patients with baseline cataract. [32] About the follow up period, the mean disease interval of DM in the current study was about 10 years, which was above the average compared to the previous studies. [23] Thus, the significant correlation between DR and sight-threatening cataract in the current study may with lesser bias.…”

Section: Discussioncontrasting

confidence: 46%

The elevated risk of sight-threatening cataract in diabetes with retinopathy: a cohort study

Nien

Lee

Chen

et al. 2020

Preprint

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Background To survey the effect of diabetic retinopathy (DR) on the development of sight-threatening cataract via National Health Insurance Research Database of Taiwan.Methods Patients diagnosed with diabetes mellitus (DM) and DR were enrolled in the study group. The age and gender-matched DM individuals without DR and patients without DM served as the DM control group and non-DM control group, both with 1:4 ratios. The outcome was set as the performance of cataract surgery. Cox proportional hazard regression was used to calculate the adjusted hazard ratio (aHR) of DR with considering multiple factors of cataract formation.Results A total of 3,297 DR patients, 13,188 DM control patients and 13,188 non-DM controls were enrolled. There were 919 events (27.87 percent) of sight-threatening cataract in the study group while another 1,108 events (8.40 percent) in the DM control group and 957 events (7.26 percent) in the non-DM control group. After multivariable analysis, the study group showed a higher aHR of cataract surgery (2.93, 95% CI: 2.60-3.30) and a higher cumulative probability of cataract surgery compared to both the DM control and non-DM control groups (both Log rank P<0.001). Besides, both the proliferative DR (3.90, 95% CI: 3.42-4.45) and non-proliferative DR (2.35, 95% CI: 2.08-2.65) subgroups showed a higher aHR of cataract surgery than the DM control group.Conclusion The presence of DR will increase the risk for development of sight-threatening cataract that surgery is warranted, and the effect is prominent in both the proliferative DR and non-proliferative DR.

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“…The MG atrophy increases with age, and the incidence of cataract surgery is also strongly age related. 14 However, few reports are available describing the MG health of this population. 10 , 11 Furthermore, the prevalence of dry eye and MGD in China is obviously higher than that of European countries.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Meibomian Gland Atrophy and the Potential Risk Factors for Middle Aged to Elderly Patients With Cataracts

Lin

Chen

et al. 2020

Trans. Vis. Sci. Tech.

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To explore the characteristics of meibomian gland (MG) atrophy and its potential risk factors in the age-related cataract population. Methods: Patients who underwent cataract surgery at age 40 or older were enrolled in this study. Preoperative clinical measurement records were obtained, including lipid layer thickness, tear meniscus height, noninvasive breakup time, and meiboscore. The meibomian gland atrophy ratio (MGAR) was measured by the ImageJ software. Univariate regression analysis and multivariate regression analysis were used to analyze the risk factors for MG atrophy. Results: Female patients had less atrophy of the MG compared with male patients. The MGAR, meiboscore, tear meniscus height (TMH), and lipid layer thickness (LLT) gradually increased with age. However, the noninvasive breakup time decreased with age. The multivariate regression analysis indicated that dyslipidemia and increased triglyceride levels were identified as independent protective factors for MG atrophy. We further stratified the model by sex, and the following results showed only in the female patients with dyslipidemia and increased triglyceride had decreased MG atrophy. No significant correlation was observed between MG atrophy and tear film parameters including TMH, noninvasive breakup time, and LLT. Conclusions: Our study suggests that age, sex, and diabetes are potential risk factors for MG atrophy. In addition, dyslipidemia and increased triglyceride levels are independent protective factors for MG atrophy in the elderly female population. Translational Relevance: MG atrophy is the leading cause of meibomian gland dysfunction. To study the characteristics and risk factors of MG atrophy in cataract patients would be helpful to predict and prevent postoperative development of MGD.

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Six-Year Incidence of and Risk Factors for Cataract Surgery in a Multi-ethnic Asian Population

Cited by 27 publications

References 38 publications

Frequency of cataract surgery and its impact on visual function—results from the German Gutenberg Health Study

Frequency of cataract surgery and its impact on visual function—results from the German Gutenberg Health Study

The elevated risk of sight-threatening cataract in diabetes with retinopathy: a cohort study

Characterization of Meibomian Gland Atrophy and the Potential Risk Factors for Middle Aged to Elderly Patients With Cataracts

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