Sixth Åland Island Conference on von Willebrand disease

Berntorp, Erik; Trakymienė, Sonata Šaulytė; Federici, Augusto B.; Holstein, Katharina; Corrales-Medina, Fernando F.; Pierce, Glenn F.; Srivastava, Alok; Prondzinski, M. von Depka; Johnsen, Jill M.; Zupan, Irena Preložnik; Halimeh, Susan; Nummi, Vuokko; Roberts, Jonathan C.

doi:10.1111/hae.14495

Cited by 4 publications

(2 citation statements)

References 57 publications

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“…Ангиогемофилия или болезнь фон Виллебранда, впервые описанная др. Эрик фон Виллебранд, наиболее распространенное аутосомно-наследственное нарушение свертываемости крови [1][2][3][4]. Это вызвано дефицитом или дисфункцией фактора фон Виллебранда (ФВ), белка плазмы, который опосредует начальную адгезию тромбоцитов в местах повреждения сосудов, а также связывает и стабилизирует фактор свертывания крови VIII (FVIII) в кровообращении.…”

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“…გიუნელ მ. ეფენდიევა 1 , ლეილა მ. რზაკულიევა 1 , ელმირა ა. კადიმოვა 2 ორსულობა და მშობიერობა ქალებში ანგიოჰემოფილიით აზერბაიჯანის ექიმთა დახელოვნების სახელმწიფო ინსტიტუტი.…”

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Pregnancy and Delivery in Women With Angiohemophilia

AFANDIYEVA,

RZAKULIYEVA,

GADIMOVA

2023

jecm

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Insufficiency of the coagulation system during pregnancy can endanger the health of patients with angiohemophilia and the fetus. The goal is to estimate changes in blood coagulation parameters as pregnancy progresses in patients with angiohemophilia. Materials and methods. 15 pregnant women with mild angiohemophilia (main group) and 20 pregnant women without hereditary and gestational coagulopathy (control group) were examined. Research methods included survey and examination of pregnant women, anamnestic data, analysis of information from pregnant women's cards. Coagulological examination is performed according to 17 parameters. Results. The average age of the main group of pregnant women was 28.78±3.61 years, the average age was 12.7±1.05 years. Significant differences between the groups were noted in the frequency of menorrhagia (р=0.006) and dysmenorrhea (р<0.001). A significant difference in the frequency of chronic endometritis (р<0.001), vaginitis (р=0.015), anemia (р=0.006) and gastrointestinal diseases (р=0.015) was revealed in the main group compared to the control group. Complications occurred in 46.7% of pregnant women in the first trimester, in 53.3% of pregnant women in the second trimester, and in 60.0% of pregnant women in the third trimester. The chance of complications in the III trimester was high (OR=0.762, 95% CI 0.179-3.241, р<0.05). Head presentation was determined in 80.0%, pelvic presentation -in 20.0% of cases. In the III trimester of patients of the main group, prothrombin time and activated partial thrombin time significantly exceeded the control ones (р<0.001), a significant increase in factor VII (p=0.037) and a decrease in factor VIII (р<0.001) were revealed. Conclusion. The clinical status of pregnant women with angiohemophilia is characterized by complicated gynecological and obstetric anamnesis and changes in all parameters of the coagulogram in the III trimester.

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Pregnancy and Delivery in Women With Angiohemophilia

AFANDIYEVA,

RZAKULIYEVA,

GADIMOVA

2023

jecm

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A need to increase von Willebrand disease awareness: vwdtest.com – A global initiative to help address this gap

et al. 2023

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Sixth Åland Island Conference on von Willebrand disease

et al. 2022

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IntroductionThe sixth Åland Islands Conference on von Willebrand disease (VWD) on the Åland Islands, Finland, was held from 20 to 22 September 2018.AimThe meeting brought together experts in the field of VWD from around the world to share the latest advances and knowledge in VWD.Results and discussionThe topics covered both clinical aspects of disease management, and biochemical and laboratory insights into the disease. The clinical topics discussed included epidemiology, diagnosis and treatment of VWD in different countries, management of children with VWD, bleeding control during surgery, specific considerations for the management of type 3 VWD and bleeding control in women with VWD. Current approaches to the management of acquired von Willebrand syndrome were also discussed. Despite significant advances in the understanding and therapeutic options for VWD, there remain many challenges to be overcome in order to optimise patient care. In comparison with haemophilia A, there are very few registries of VWD patients, which would be a valuable source of data on the condition and its management. VWD is still underdiagnosed, and many patients suffer recurrent or severe bleeding that could be prevented. Awareness of VWD among healthcare practitioners, including non‐haematologists, should be improved to allow timely diagnosis and intervention. Diagnosis remains challenging, and the development of fast, simple assays may help to facilitate accurate and rapid diagnosis of VWD.

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Sixth Åland Island Conference on von Willebrand disease

Cited by 4 publications

References 57 publications

Pregnancy and Delivery in Women With Angiohemophilia

Pregnancy and Delivery in Women With Angiohemophilia

A need to increase von Willebrand disease awareness: vwdtest.com – A global initiative to help address this gap

Sixth Åland Island Conference on von Willebrand disease

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