Size and charge dual-transformable mesoporous nanoassemblies for enhanced drug delivery and tumor penetration

Chen, Liang; Zhao, Tiancong; Zhao, Mengyao; Wang, Wenxing; Sun, Chia‐Chung; Liu, Lu; Li, Qin; Zhang, Fan; Zhao, Dongyuan; Li, Xiaomin

doi:10.1039/c9sc06260b

Cited by 76 publications

(40 citation statements)

References 46 publications

(45 reference statements)

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“…Finally, the CTAB was repeatedly extracted by acid-ethanol solution under 80 °C. The modification of amino groups and 4-formylbenzoic acid was consistent with our previous work [ 27 ].…”

Section: Methodssupporting

confidence: 92%

“…3 A). Rose Bengal (RB) was selected and loaded into UCMS@Pep-aPDL1 owing to the efficient Förster resonance energy transfer between RB and UCNPs, as demonstrated in our previous report [ 27 ]. The loading efficiency of RB was calculated to be 13.59 %, implying that the large pores of the mesoporous silica allow a high loading efficiency of photosensitizers [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

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Peptide vaccine-conjugated mesoporous carriers synergize with immunogenic cell death and PD-L1 blockade for amplified immunotherapy of metastatic spinal

Wang

Chen

et al. 2021

J Nanobiotechnol

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The clinical treatment of metastatic spinal tumor remains a huge challenge owing to the intrinsic limitations of the existing methods. Programmed cell death protein 1 (PD1)/programmed cell death ligand 1 (PD-L1) pathway blockade has been explored as a promising immunotherapeutic strategy; however, their inhibition has a low response rate, leading to the minimal cytotoxic T cell infiltration. To ameliorate the immunosuppressive microenvironment of intractable tumor and further boost the efficacy of immunotherapy, we report an all-round mesoporous nanocarrier composed of an upconverting nanoparticle core and a large-pore mesoporous silica shell (UCMS) that is simultaneously loaded with photosensitizer molecules, the IDO-derived peptide vaccine AL-9, and PD-L1 inhibitor. The IDO-derived peptide can be recognized by the dendritic cells and presented to CD8+ cytotoxic T cells, thereby enhancing the immune response and promoting the killing of the IDO-expressed tumor cells. Meanwhile, the near-infrared (NIR) activated photodynamic therapy (PDT) could induce immunogenic cell death (ICD), which promotes the effector T-cell infiltration. By combining the PDT-elicited ICD, peptide vaccine and immune checkpoint blockade, the designed UCMS@Pep-aPDL1 successfully potentiated local and systemic antitumor immunity and reduced the progression of metastatic foci, demonstrating a synergistic strategy for cancer immunotherapy.

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“…Finally, the CTAB was repeatedly extracted by acid-ethanol solution under 80 °C. The modification of amino groups and 4-formylbenzoic acid was consistent with our previous work [ 27 ].…”

Section: Methodssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Peptide vaccine-conjugated mesoporous carriers synergize with immunogenic cell death and PD-L1 blockade for amplified immunotherapy of metastatic spinal

Wang

Chen

et al. 2021

J Nanobiotechnol

Self Cite

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“…Therefore, the positively charged nanocarriers would strongly associate to the negative proteins via electrostatic attraction, which would also affect how nanoparticles interact with cells (or uptake mechanism) and influence biodistribution of NDDSs [ 33 – 35 ]. While, neutral nanoparticles or slightly negatively charged nanoparticles could resist the protein adsorption for a longer time [ 36 ]. It should be noted that once nanoparticles contact with biological environments, they are modified by adsorption of biomolecules on their surface, which is called protein corona.…”

Section: Effect Of Surface Charge On the Uptake Of Nanocarriersmentioning

confidence: 99%

Charge reversal nano-systems for tumor therapy

Zhang

Chen

et al. 2022

J Nanobiotechnol

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Surface charge of biological and medical nanocarriers has been demonstrated to play an important role in cellular uptake. Owing to the unique physicochemical properties, charge-reversal delivery strategy has rapidly developed as a promising approach for drug delivery application, especially for cancer treatment. Charge-reversal nanocarriers are neutral/negatively charged at physiological conditions while could be triggered to positively charged by specific stimuli (i.e., pH, redox, ROS, enzyme, light or temperature) to achieve the prolonged blood circulation and enhanced tumor cellular uptake, thus to potentiate the antitumor effects of delivered therapeutic agents. In this review, we comprehensively summarized the recent advances of charge-reversal nanocarriers, including: (i) the effect of surface charge on cellular uptake; (ii) charge-conversion mechanisms responding to several specific stimuli; (iii) relation between the chemical structure and charge reversal activity; and (iv) polymeric materials that are commonly applied in the charge-reversal delivery systems. Graphical Abstract

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“…However, due to the existence of various barriers, they often have difficulty in reaching the core of the tumor. Therefore, nanodrugs of variable size can be used to simultaneously achieve long-time circulation, good passive targeting, and high permeability [ 178 , 179 , 180 , 181 , 182 , 183 ].…”

Section: Nanoparticles For Enhancing the Tumor Epr Effectmentioning

confidence: 99%

Nanodrug Delivery Systems Modulate Tumor Vessels to Increase the Enhanced Permeability and Retention Effect

Dong

Sun

Huang

et al. 2021

JPM

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The use of nanomedicine for antitumor therapy has been extensively investigated for a long time. Enhanced permeability and retention (EPR) effect-mediated drug delivery is currently regarded as an effective way to bring drugs to tumors, especially macromolecular drugs and drug-loaded pharmaceutical nanocarriers. However, a disordered vessel network, and occluded or embolized tumor blood vessels seriously limit the EPR effect. To augment the EPR effect and improve curative effects, in this review, we focused on the perspective of tumor blood vessels, and analyzed the relationship among abnormal angiogenesis, abnormal vascular structure, irregular blood flow, extensive permeability of tumor vessels, and the EPR effect. In this commentary, nanoparticles including liposomes, micelles, and polymers extravasate through the tumor vasculature, which are based on modulating tumor vessels, to increase the EPR effect, thereby increasing their therapeutic effect.

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Size and charge dual-transformable mesoporous nanoassemblies for enhanced drug delivery and tumor penetration

Abstract: Size and charge dual-transformable core@satellite structured nanoassemblies are developed to overcome multiple biological barriers in a drug delivery system.

Cited by 76 publications

References 46 publications

Peptide vaccine-conjugated mesoporous carriers synergize with immunogenic cell death and PD-L1 blockade for amplified immunotherapy of metastatic spinal

Peptide vaccine-conjugated mesoporous carriers synergize with immunogenic cell death and PD-L1 blockade for amplified immunotherapy of metastatic spinal

Charge reversal nano-systems for tumor therapy

Nanodrug Delivery Systems Modulate Tumor Vessels to Increase the Enhanced Permeability and Retention Effect

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