2014
DOI: 10.1021/jp502898a
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Size and Phase Control of Cubic Lyotropic Liquid Crystal Nanoparticles

Abstract: The effective use of lyotropic liquid crystalline dispersions, such as cubosomes, as drug delivery vehicles requires that they have tailored physical characteristics that suit specific therapeutics and external conditions. Here, we have developed phytantriol-based cubosomes from a dispersion of unilamellar vesicles and show that we can control their size as well as the critical packing parameter (CPP) of the amphiphilic bilayer through regulation of temperature and salt concentration, respectively. Using the a… Show more

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Cited by 37 publications
(33 citation statements)
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“…Other directions of research in the stabilization of lyotropic liquid crystalline nanostructured particles may include using charged polymers to stabilize dispersions [158,159,222,223]. In particular, Angelov et al stabilized a dispersion of fusogenic monoolein, using cationic lipid dioctadecyldimethylammonium bromide and PEGylated lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(methoxy-(polyethyleneglycol)-2000) ammonium salt (DOPE-PEG 2000 ) [223].…”
Section: Future Developments In the Stabilization Of Cubosomesmentioning
confidence: 99%
“…Other directions of research in the stabilization of lyotropic liquid crystalline nanostructured particles may include using charged polymers to stabilize dispersions [158,159,222,223]. In particular, Angelov et al stabilized a dispersion of fusogenic monoolein, using cationic lipid dioctadecyldimethylammonium bromide and PEGylated lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(methoxy-(polyethyleneglycol)-2000) ammonium salt (DOPE-PEG 2000 ) [223].…”
Section: Future Developments In the Stabilization Of Cubosomesmentioning
confidence: 99%
“…22,23 The effect of BSA incorporation into PHY dispersions was studied by varying the concentration of BSA included during the cubosome production. Dynamic light scattering was then used to obtain the size and polydispersity of the nanoparticles followed by SAXS and cryo-TEM to assess the phase of the dispersions.…”
Section: Characterization Of Cubosome Formationsmentioning
confidence: 99%
“…These range from use in pharmaceutical sciences for drug delivery vessels and biosensors, to materials templates for fuel cells, solar cells, and for photonic crystals . When combined with a “capping agent”, phytantriol can be converted into stable “cubosome” or “hexosome” particles . Key to mesophase properties and to applications is the ionic transport through the water channels.…”
Section: Introductionmentioning
confidence: 99%