Size-change and deposition of conventional and composite cigarette smoke particles during inhalation in a subject-specific airway model

Zhang, Zhe; Kleinstreuer, Clement; Hyun, Seung

doi:10.1016/j.jaerosci.2011.12.002

Cited by 74 publications

(63 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The subject-specific geometry of the airways was provided by Prof. C. Kleinstreuer (North Carolina State University, NC) and was employed in recent numerical studies of cigarette smoke inhalation (Zhang et al 2012). The subject is a 47-year-old healthy male volunteer, 174 cm in height and 78 kg in weight, with no history of respiratory diseases.…”

Section: Experimental Methodsmentioning

confidence: 99%

Three-dimensional inspiratory flow in the upper and central human airways

et al. 2015

View full text Add to dashboard Cite

Section: Experimental Methodsmentioning

confidence: 99%

Three-dimensional inspiratory flow in the upper and central human airways

et al. 2015

View full text Add to dashboard Cite

“…Although this approach is appropriate for product assessment, the cascade impactor is labor-intensive and unsuitable for product development support or for screening purposes when a fast response time is required. Recently, several working groups have performed size distribution measurements using analytical instruments applied to the mainstream of conventional cigarettes and e-cigarette products (Ingebrethsen et al, 2012;Zhang et al, 2012Zhang et al, , 2013. The use of real-time aerosol physical characterization techniques typically allows measurement of aerosol size distributions from which the MMAD is determined assuming the droplets are spherical.…”

Section: Introductionmentioning

confidence: 99%

A scattering methodology for droplet sizing of e-cigarette aerosols

Pratte

Cosandey

Goujon-Ginglinger

2016

Inhalation Toxicology

View full text Add to dashboard Cite

Context: Knowledge of the droplet size distribution of inhalable aerosols is important to predict aerosol deposition yield at various respiratory tract locations in human. Optical methodologies are usually preferred over the multi-stage cascade impactor for high-throughput measurements of aerosol particle/droplet size distributions. Objective: Evaluate the Laser Aerosol Spectrometer technology based on Polystyrene Sphere Latex (PSL) calibration curve applied for the experimental determination of droplet size distributions in the diameter range typical of commercial e-cigarette aerosols (147-1361 nm). Materials and methods: This calibration procedure was tested for a TSI Laser Aerosol Spectrometer (LAS) operating at a wavelength of 633 nm and assessed against model diethyl-hexyl-sebacat (DEHS) droplets and e-cigarette aerosols. The PSL size response was measured, and intra-and between-day standard deviations calculated. Results: DEHS droplet sizes were underestimated by 15-20% by the LAS when the PSL calibration curve was used; however, the intra-and between-day relative standard deviations were 53%. This bias is attributed to the fact that the index of refraction of PSL calibrated particles is different in comparison to test aerosols. This 15-20% does not include the droplet evaporation component, which may reduce droplet size prior a measurement is performed. Aerosol concentration was measured accurately with a maximum uncertainty of 20%. Count median diameters and mass median aerodynamic diameters of selected e-cigarette aerosols ranged from 130-191 nm to 225-293 nm, respectively, similar to published values. Discussion and conclusion: The LAS instrument can be used to measure e-cigarette aerosol droplet size distributions with a bias underestimating the expected value by 15-20% when using a precise PSL calibration curve. Controlled variability of DEHS size measurements can be achieved with the LAS system; however, this method can only be applied to test aerosols having a refractive index close to that of PSL particles used for calibration.

show abstract

“…Deposition of MCS particle in human respiratory airways is a complex process involving multiple mechanisms, such as impaction, sedimentation, diffusion, hygroscopic growth, coagulation, as well as possible cloud motion and charge effect (Zhang et al, 2012a).The Multiple-Path Particle Dosimetry (MPPD V2.11) model developed jointly by the Hamner Institutes for Health Sciences and the Dutch National Institute for Public Health and the Environment has been used for prediction of aerosol deposition fractions in different compartments of the human respiratory tract. During smoking, the cigarette puff is mixed with a volume of ambient air equal to the average lung tidal volume (500 mL) that delivers the smoke to the lungs (Ingebrethsen et al, 2011).…”

Section: Respiratory Tract Deposition Modelmentioning

confidence: 99%

PAHs in Size Fractionate Mainstream Cigarette Smoke, Predictive Deposition and Associated Inhalation Risk

Tiwari

Sahu

Pandit

2017

Aerosol Air Qual. Res.

View full text Add to dashboard Cite

Size fractionated mainstream cigarette smoke (MCS) samples were collected with variable configuration cascade impactor (VCCI). Samples were extracted ultrasonically and analysis of sixteen priority polycyclic aromatic hydrocarbons (PAHs) was performed using high performance liquid chromatography (HPLC) coupled with UV-visible detector. Identification of PAHs were also carried out using gas chromatography coupled with mass spectrometry (GC-MS) technique. Data of size fractionate PAHs in MCS were used to calculate size dependent deposition in different compartment of human respiratory tract using multiple path particle dosimetry (MPPD) model. All brand cigarette smoke showed similar trends of particle mass and PAHs size distribution peaked at two sizes 0.3-0.1 µm and 0.75-1.13 µm aerodynamic diameter. All tested brands of MCS recorded around 48.75% of two and three-ring PAHs, 23 to 25% fourring PAHs and 26-27% five and higher rings PAHs of total analyzed PAHs. Benzo[a]pyrene equivalent (B[a]P eq ) PAHs emission in MCS was found to be 110 ± 12 (µ ± 1σ) ng per cigarette for tested brands. Total deposition fraction in respiratory tract was found to be 0.69 ± 0.26 for tested size ranges. Average 5 th and 95 th percentile values of incremental lifetime cancer risk (ILCR) for smoker due to PAHs exposure were found to be 1.3 × 10 -5 to 3.9 × 10 -5 respectively for tested cigarette brands.

show abstract

Size-change and deposition of conventional and composite cigarette smoke particles during inhalation in a subject-specific airway model

Cited by 74 publications

References 51 publications

Three-dimensional inspiratory flow in the upper and central human airways

Three-dimensional inspiratory flow in the upper and central human airways

A scattering methodology for droplet sizing of e-cigarette aerosols

PAHs in Size Fractionate Mainstream Cigarette Smoke, Predictive Deposition and Associated Inhalation Risk

Contact Info

Product

Resources

About