Size-controlled bimodal <i>in vivo</i> nanoprobes as near-infrared phosphors and positive contrast agents for magnetic resonance imaging

Okubo, Kyohei; Takeda, Ryuta; Murayama, Shuhei; Umezawa, Masakazu; Kamimura, Masao; Osada, Kensuke; Aoki, Ichio; Soga, Kohei

doi:10.1080/14686996.2021.1887712

Cited by 15 publications

(11 citation statements)

References 71 publications

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“…More importantly, RENPs by co‐doping different rare‐earth ions in the host matrix can controllably modulate their optical properties, including their absorption and emission light, especially the fluorescence signal in the NIR‐II region, providing as promising bimodal probes that allow the NIR‐II (over 1000 nm) fluorescence imaging in living bodies for visual diseases diagnosis. [ 73 ] However, the poor water solubility of RENPs hinders their further applications in bio‐imaging. Therefore, surface modification of RENPs can improve their aqueous dispersion properties and expand their application in cancer monitor and biomedical research.…”

Section: Nir‐ii Fluorescence Imaging For Tumor Tissue Visualizationmentioning

confidence: 99%

Recent Advances in Near‐Infrared‐II Fluorescence Imaging for Deep‐Tissue Molecular Analysis and Cancer Diagnosis

Meng

Pang

Zhang

et al. 2022

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Fluorescence imaging with high sensitivity and minimal invasiveness has received tremendous attention, which can accomplish visualized monitoring and evaluation of cancer progression. Compared with the conventional first near‐infrared (NIR‐I) optical window (650–950 nm), fluorescence imaging in the second NIR optical window (NIR‐II, 950–1700 nm) exhibits deeper tissue penetration capability and higher temporal‐spatial resolution with lower background interference for achieving deep‐tissue in vivo imaging and real‐time monitoring of cancer development. Encouraged by the significant preponderances, a variety of multifunctional NIR‐II fluorophores have been designed and fabricated for sensitively imaging biomarkers in vivo and visualizing the treatment procedure of cancers. In this review, the differences between NIR‐I and NIR‐II fluorescence imaging are briefly introduced, especially the advantages of NIR‐II fluorescence imaging for the real‐time visualization of tumors in vivo and cancer diagnosis. An important focus is to summarize the NIR‐II fluorescence imaging for deep‐tissue biomarker analysis in vivo and tumor tissue visualization, and a brief introduction of NIR‐II fluorescence imaging‐guided cancer therapy is also presented. Finally, the significant challenges and reasonable prospects of NIR‐II fluorescence imaging for cancer diagnosis in clinical applications are outlined.

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Section: Nir‐ii Fluorescence Imaging For Tumor Tissue Visualizationmentioning

confidence: 99%

Recent Advances in Near‐Infrared‐II Fluorescence Imaging for Deep‐Tissue Molecular Analysis and Cancer Diagnosis

Meng

Pang

Zhang

et al. 2022

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“…The final concentrations of the NPs were set at 1–9 mg/mL because the concentration order of milligrams per milliliter is the dose commonly used for imaging contrast agents for visualizing blood flow. 27 , 36 , 44 FT-IR spectra including amide bands were recorded using an FT/IR-6200 spectrometer (Shimadzu Co., Kyoto, Japan) for the mixed samples sandwiched between two CaF 2 plate windows (spacer 0.025 mm). The analysis was performed for each sample within 30 min after mixing Aβ 16–20 with the NP dispersion.…”

Section: Methodsmentioning

confidence: 99%

Changes in the Secondary Structure and Assembly of Proteins on Fluoride Ceramic (CeF₃) Nanoparticle Surfaces

Sakaguchi

Kaumbekova

Itano

et al. 2022

ACS Appl. Bio Mater.

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Fluoride nanoparticles (NPs) are materials utilized in the biomedical field for applications including imaging of the brain. Their interactions with biological systems and molecules are being investigated, but the mechanism underlying these interactions remains unclear. We focused on possible changes in the secondary structure and aggregation state of proteins on the surface of NPs and investigated the principle underlying the changes using the amyloid β peptide (Aβ 16–20 ) based on infrared spectrometry. CeF 3 NPs (diameter 80 nm) were synthesized via thermal decomposition. Infrared spectrometry showed that the presence of CeF 3 NPs promotes the formation of the β-sheet structure of Aβ 16–20 . This phenomenon was attributed to the hydrophobic interaction between NPs and Aβ peptides in aqueous environments, which causes the Aβ peptides to approach each other on the NP surface and form ordered hydrogen bonds. Because of the coexisting salts on the secondary structure and assembly of Aβ peptides, the formation of the β-sheet structure of Aβ peptides on the NP surface was suppressed in the presence of NH 4 + and NO 3 – ions, suggesting the possibility that Aβ peptides were adsorbed and bound to the NP surface. The formation of the β-sheet structure of Aβ peptides was promoted in the presence of NH 4 + , whereas it was suppressed in the presence of NO 3 – because of the electrostatic interaction between the lysine residue of the Aβ peptide and the ions. Our findings will contribute to comparative studies on the effect of different NPs with different physicochemical properties on the molecular state of proteins.

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“…36 The reported relaxivity values 0.27 (minimum r 1 ) and 160 (maximum r 2 ) mM À1 s À1 depends on eld strength, 36,38 size and morphology 36,38 and coating. 39 MRI imaging would allow for deep tissue imaging and would be complementary to X-ray luminescence imaging and stimulation, allowing for non-invasive localization of nanophosphors in vivo.…”

Section: Biotin Functionalized Nagdf 4 :Eu@siomentioning

confidence: 99%

X-ray excited luminescence spectroscopy and imaging with NaGdF₄:Eu and Tb

et al. 2021

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Size-controlled bimodal in vivo nanoprobes as near-infrared phosphors and positive contrast agents for magnetic resonance imaging

Abstract: Soga (2021) Size-controlled bimodal invivo nanoprobes as near-infrared phosphors and positive contrast agents for magnetic

Cited by 15 publications

References 71 publications

Recent Advances in Near‐Infrared‐II Fluorescence Imaging for Deep‐Tissue Molecular Analysis and Cancer Diagnosis

Recent Advances in Near‐Infrared‐II Fluorescence Imaging for Deep‐Tissue Molecular Analysis and Cancer Diagnosis

Changes in the Secondary Structure and Assembly of Proteins on Fluoride Ceramic (CeF₃) Nanoparticle Surfaces

X-ray excited luminescence spectroscopy and imaging with NaGdF₄:Eu and Tb

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Size-controlled bimodal in vivo nanoprobes as near-infrared phosphors and positive contrast agents for magnetic resonance imaging

Abstract: Soga (2021) Size-controlled bimodal invivo nanoprobes as near-infrared phosphors and positive contrast agents for magnetic

Cited by 15 publications

References 71 publications

Recent Advances in Near‐Infrared‐II Fluorescence Imaging for Deep‐Tissue Molecular Analysis and Cancer Diagnosis

Recent Advances in Near‐Infrared‐II Fluorescence Imaging for Deep‐Tissue Molecular Analysis and Cancer Diagnosis

Changes in the Secondary Structure and Assembly of Proteins on Fluoride Ceramic (CeF3) Nanoparticle Surfaces

X-ray excited luminescence spectroscopy and imaging with NaGdF4:Eu and Tb

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Product

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Changes in the Secondary Structure and Assembly of Proteins on Fluoride Ceramic (CeF₃) Nanoparticle Surfaces

X-ray excited luminescence spectroscopy and imaging with NaGdF₄:Eu and Tb