Size-controlled synthesis, surface functionalization, and biological applications of thiol-organosilica particles

Nakamura, Michihiro; Ozaki, Shuji; Abe, Masahiro; Doi, Hiroyuki; Matsumoto, Toshio; Ishimura, Kazunori

doi:10.1016/j.colsurfb.2010.03.008

Cited by 54 publications

(61 citation statements)

References 24 publications

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“…This is an outstanding starting point, as lack of adverse side effects on healthy cells is absolutely mandatory, even envisaging anti-cancer applications. Once functionalized, BNNTs may further improve their interaction with the biological environment (Chen et al, 2009;Ciofani et al, 2012;Nakamura et al, 2010;Yang et al, 2011), and, moreover, can be theoretically targeted to specific tissues and organs. Thus, BNNTs can be exploited as effective nanocarriers, providing safe and efficient targeted release of biomolecules into desired cells and tissues (Lacerda et al, 2008(Lacerda et al, , 2007Liu et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Folate-grafted boron nitride nanotubes: Possible exploitation in cancer therapy

Ferreira

Marino

Rocca

et al. 2015

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Folate-grafted boron nitride nanotubes: Possible exploitation in cancer therapy

Ferreira

Marino

Rocca

et al. 2015

International Journal of Pharmaceutics

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“…Therefore, the particles could have adsorbed antigenic molecules that were derived from commensal microbes in the intestinal lumen, which could explain why thiol-organosilica particles have an increased ability to bind proteins, as reported previously. 28 Therefore, orally administered, smaller particles could be significantly taken up by CD11b + macrophages from PPs, rather than by 33D1 + DCs, but further studies are needed to clarify the mechanism of uptake of thiol-organosilica particles by PP cells.…”

Section: Discussionmentioning

confidence: 99%

“…The particles were prepared from 3-mercaptopropyltrimethoxysilane as the silica source, and five different sizes of particles containing Rh B (100 nm, 180 nm, 365 nm, 745 nm, and 925 nm in diameter) were prepared according to previous methods with slight modification 28,32 (Figure 1B and Table 1). The images of particles were obtained with a Hitachi H7650 electron microscope (Tokyo, Japan), and the sizes and standard deviations of about 200 particles were analyzed by Image-Pro Plus software (Media Cybernetics, Inc, Bethesda, MD).…”

Section: Preparation and Characterization Of Thiol-organosilica Partimentioning

confidence: 99%

“…[26][27][28][29][30][31][32] Various sizes of fluorescent, thiol-organosilica particles can be synthesized with a narrow size distribution, high dispersion, and unique surface charge. 28 Recently it was reported that thiol-organosilica particles have excellent adhesion ability to mucosal surfaces, possibly due to effects of thiol residue. 33 The authors of this present study previously administered various sizes of thiol-organosilica particles orally into mice and demonstrated the size-dependent uptake and novel pathways in PP ( Figure 1A).…”

Section: Introductionmentioning

confidence: 99%

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Histochemical and biochemical analysis of the size-dependent nanoimmunoresponse in mouse Peyer's patches using fluorescent organosilica particles

Awaad¹,

Nakamura²,

Ishimura³

2012

IJN

Self Cite

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Background/objective The size-dependent mucosal immunoresponse against nanomaterials (nanoimmunoresponse) is an important approach for mucosal vaccination. In the present work, the size-dependent nanoimmunoresponse of mouse Peyer’s patches (PPs) and immunoglobulin A (IgA) level was investigated using fluorescent thiol-organosilica particles. Methods Various sizes of fluorescent thiol-organosilica particles (100, 180, 365, 745, and 925 nm in diameter) were administered orally. PPs were analyzed histochemically, and IgA levels in PP homogenates, intestinal secretions around PPs, and bile were analyzed biochemically. Results When compared with the larger particles (745 and 925 nm), oral administration of smaller thiol-organosilica particles (100, 180, and 365 nm) increased the number of CD11b + macrophages and IgA + cells in the subepithelial domes of the PPs. Additionally, administration of larger particles induced the expression of alpha-L-fucose and mucosal IgA on the surface of M cells in the follicle-associated epithelia of PPs and increased the number of 33D1 + dendritic cells in the subepithelial domes of the PPs. IgA contents in the bile and PP homogenates were high after the administration of the 100 nm particles, but IgA levels in the intestinal secretions were high after the administration of the 925 nm particles. Two size-dependent routes of IgA secretions into the intestinal lumen, the enterohepatic route for smaller particles and the mucosal route for larger particles were proposed. Conclusion Thiol-organosilica particles demonstrated size-dependent nanoimmunoresponse after oral administration. The size of the particles may control the mucosal immunity in PPs and were useful in mucosal vaccination approaches.

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“…[1] Nanoparticles provide the possibility for controlled and targeted release of compounds, which depend on the proper selection of polymer chemistry, the surface modification of particles with specific ligands, and the size and polydispersity of such particles. [2] The production of particles with controlled size and controlled size distribution has been the subject of several works, [3,4,5] including studies on developing nanoparticles from biodegradable and biocompatible polymers. [6] Various techniques can be used to produce micro-and nanoparticles of polymers, such as solvent evaporation, saltingout, dialysis, micro-emulsion, mini-emulsion, surfactant-free emulsion, and interfacial polymerization.…”

Section: Introductionmentioning

confidence: 99%

Production of microparticles of PHBV polymer impregnated with progesterone by supercritical fluid technology

et al. 2016

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This work reports the synthesis of particles based on poly(3-hydroxybutirate-co-3-hydroxyvalerate) (PHBV) polymer that were impregnated with progesterone. The PHBV particles were obtained by supercritical CO 2 (scCO 2 ) anti-solvent expansion (SAS). scCO 2 was also used at a high pressure (25 MPa) and moderate temperature (323 K) for the impregnation of progesterone into the PHBV particles at different impregnation times. In vitro release tests showed that the half-time of progesterone release in a hydro-alcoholic medium, for the samples produced with impregnation times of 2-32 h, was 3-5 h, with the higher release times generally related to smaller impregnation times.

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Size-controlled synthesis, surface functionalization, and biological applications of thiol-organosilica particles

Cited by 54 publications

References 24 publications

Folate-grafted boron nitride nanotubes: Possible exploitation in cancer therapy

Folate-grafted boron nitride nanotubes: Possible exploitation in cancer therapy

Histochemical and biochemical analysis of the size-dependent nanoimmunoresponse in mouse Peyer's patches using fluorescent organosilica particles

Production of microparticles of PHBV polymer impregnated with progesterone by supercritical fluid technology

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