Size effect of platinum nanoparticles in simulated anticancer photothermal therapy

Inter-Organelle Contact Sites Mediate the Intracellular Antioxidant Activity of Platinum Nanozymes: A New Perspective on Cell–Nanoparticle Interaction and Signaling

“…Moreover, their activities as horseradish peroxidase (HRP) , and superoxide dismutase (SOD) have also been described . In addition, Pt-based nanoparticles are able to absorb light in the biological window (650–850 nm), in an extent depending on their physical–chemical properties (e.g., size, shape, and crystalline structure), suggesting their employment as photosensitizers in photothermal therapy (PTT). − Furthermore, thanks to the abovementioned multiple features, PtNPs can be designed for combination therapy in order to improve treatment strategies. − Remarkably, the high stability of PtNPs in acidic intracellular compartments increases their cytocompatibility and tolerance in vivo compared to other metal nanoparticles, , reducing possible adverse effects, while maintaining high catalytic efficiency in situ. To achieve PtNPs with specific properties and ad hoc sizes, two well-documented approaches exist, namely, bottom-up and top-down methods. , In the top-down method, a large metal structure is mechanically broke down; in this way, the size distribution and morphologies are strictly controlled leading to the generation of fine nanoparticles .…”

Improving the Effect of Cancer Cells Irradiation with X-rays and High-Energy Protons Using Bimetallic Palladium-Platinum Nanoparticles with Various Nanostructures

“…Alternatively, the combined effect of platinum and palladium may not be present, and the more promising properties of PdPt I may only be due to the presence of palladium atoms on the surface of these NPs, which may possess better radiosensitizing properties than platinum. The differences in the estimated diameters of both types of NPs are of the order of several nm; such slight differences certainly do not affect (and if so–to a minimal extent) their cytotoxicity and photo- or radiosensitizing properties [ 44 , 45 , 46 ].…”

Platinum nanoplatforms: classic catalysts claiming a prominent role in cancer therapy

“…Thus, while Bigall et al 131 found a direct correlation between Pt size and photothermal response in aqueous suspensions, Manikandan et al 133 evaluated the PTT ability of Pt NPs in the 1–21 nm range and found no significant differences in the temperature increase upon laser irradiation with 1064 nm. Depciuch et al 134 performed another comparative study between 2 and 80 nm Pt NPs. The latter increased 6.6 °C and 6.4 °C when were irradiated under 650 nm and 808 nm lasers, respectively.…”