Size Principle of Striated Muscle Cells

Laarse, Willem J. van der; Tombe, Ariane L. des; Groot, M.B.E. Lee-de; Diegenbach, P. C.

doi:10.1163/156854298x00075

Cited by 24 publications

(11 citation statements)

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“…As a general rule, there is a positive correlation between muscle fiber diameter and oxygen diffusion distance in mammals (Van Der Laarse et al, 1998; Van Wessel et al, 2010). The limitation of having larger fiber diameters is a function of the diffusion distance across the cellular membrane and cell, with smaller fibers allowing for more rapid oxygen diffusion (Van Wessel et al, 2010; Kinsey et al, 2011; Kielhorn et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Ontogenetic changes in skeletal muscle fiber type, fiber diameter and myoglobin concentration in the Northern elephant seal (Mirounga angustirostris)

et al. 2014

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Northern elephant seals (Mirounga angustirostris) (NES) are known to be deep, long-duration divers and to sustain long-repeated patterns of breath-hold, or apnea. Some phocid dives remain within the bounds of aerobic metabolism, accompanied by physiological responses inducing lung compression, bradycardia, and peripheral vasoconstriction. Current data suggest an absence of type IIb fibers in pinniped locomotory musculature. To date, no fiber type data exist for NES, a consummate deep diver. In this study, NES were biopsied in the wild. Ontogenetic changes in skeletal muscle were revealed through succinate dehydrogenase (SDH) based fiber typing. Results indicated a predominance of uniformly shaped, large type I fibers and elevated myoglobin (Mb) concentrations in the longissimus dorsi (LD) muscle of adults. No type II muscle fibers were detected in any adult sampled. This was in contrast to the juvenile animals that demonstrated type II myosin in Western Blot analysis, indicative of an ontogenetic change in skeletal muscle with maturation. These data support previous hypotheses that the absence of type II fibers indicates reliance on aerobic metabolism during dives, as well as a depressed metabolic rate and low energy locomotion. We also suggest that the lack of type IIb fibers (adults) may provide a protection against ischemia reperfusion (IR) injury in vasoconstricted peripheral skeletal muscle.

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Section: Discussionmentioning

confidence: 99%

Ontogenetic changes in skeletal muscle fiber type, fiber diameter and myoglobin concentration in the Northern elephant seal (Mirounga angustirostris)

et al. 2014

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“…Despite the diminished angiogenic response and the unaltered aerobic capacity, the fatigue resistance was increased to a similar extent in adult and old m. plantaris of C57BL/6J mice after 6 weeks overload. The proportional increase in aerobic capacity and muscle fiber size after overload was unexpected as the inverse relationship between fiber size and oxidative capacity (van der Laarse et al 1998) suggests that oxygen diffusion limitations may impose a size constraint on muscle fibers. The more homogeneous distribution of capillaries in the overloaded muscles improves muscle oxygenation (Degens et al 1994a; Goldman et al 2006; Turek et al 1989) and may make such an adaptation possible in vivo.…”

Section: Discussionmentioning

confidence: 99%

“…Muscle fiber size and oxidative metabolism are inversely related (van der Laarse et al 1998; van Wessel et al 2010), which suggests that muscle fiber size and oxidative metabolism are under coordinated control. Based on this relationship, it is to be expected that the aerobic capacity decreases during muscle (fiber) hypertrophy, and even more so in the older muscles that potentially already have a less dense capillary network to start with.…”

Section: Introductionmentioning

confidence: 99%

Blunted angiogenesis and hypertrophy are associated with increased fatigue resistance and unchanged aerobic capacity in old overloaded mouse muscle

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Busé-Pot

Harding

et al. 2016

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We hypothesize that the attenuated hypertrophic response in old mouse muscle is (1) partly due to a reduced capillarization and angiogenesis, which is (2) accompanied by a reduced oxidative capacity and fatigue resistance in old control and overloaded muscles, that (3) can be rescued by the antioxidant resveratrol. To investigate this, the hypertrophic response, capillarization, oxidative capacity, and fatigue resistance of m. plantaris were compared in 9- and 25-month-old non-treated and 25-month-old resveratrol-treated mice. Overload increased the local capillary-to-fiber ratio less in old (15 %) than in adult (59 %) muscle (P < 0.05). Although muscles of old mice had a higher succinate dehydrogenase (SDH) activity (P < 0.05) and a slower fiber type profile (P < 0.05), the isometric fatigue resistance was similar in 9- and 25-month-old mice. In both age groups, the fatigue resistance was increased to the same extent after overload (P < 0.01), without a significant change in SDH activity, but an increased capillary density (P < 0.05). Attenuated angiogenesis during overload may contribute to the attenuated hypertrophic response in old age. Neither was rescued by resveratrol supplementation. Changes in fatigue resistance with overload and aging were dissociated from changes in SDH activity, but paralleled those in capillarization. This suggests that capillarization plays a more important role in fatigue resistance than oxidative capacity.

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“…7) (van der Laarse et al, 1997; van Wessel et al, 2010). According to this relation, interstitial PO 2crit for muscle fibres of these species is about 14 mmHg.…”

Section: Discussionmentioning

confidence: 99%

“…The inverse relationship between the muscle fibre CSA and oxidative capacity for different muscle fibres within a particular muscle and also among muscles fibres from different species suggests that oxygen diffusion imposes a size constraint (van der Laarse et al, 1997; van Wessel et al, 2010). In theory, this relationship can be modulated by changing capillary density or Mb concentration (van Beek-Harmsen et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Increased oxidative metabolism and myoglobin expression in zebrafish muscle during chronic hypoxia

et al. 2014

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Fish may be extremely hypoxia resistant. We investigated how muscle fibre size and oxidative capacity in zebrafish (Danio rerio) adapt during severe chronic hypoxia. Zebrafish were kept for either 3 or 6 weeks under chronic constant hypoxia (CCH) (10% air/90%N2 saturated water). We analyzed cross-sectional area (CSA), succinate dehydrogenase (SDH) activity, capillarization, myonuclear density, myoglobin (Mb) concentration and Mb mRNA expression of high and low oxidative muscle fibres. After 3 weeks of CCH, CSA, SDH activity, Mb concentration, capillary and myonuclear density of both muscle fibre types were similar as under normoxia. In contrast, staining intensity for Mb mRNA of hypoxic high oxidative muscle fibres was 94% higher than that of normoxic controls (P<0.001). Between 3 and 6 weeks of CCH, CSA of high and low oxidative muscle fibres increased by 25 and 30%, respectively. This was similar to normoxic controls. Capillary and myonuclear density were not changed by CCH. However, in high oxidative muscle fibres of fish maintained under CCH, SDH activity, Mb concentration as well as Mb mRNA content were higher by 86%, 138% and 90%, respectively, than in muscle fibres of fish kept under normoxia (P<0.001). In low oxidative muscle fibres, SDH activity, Mb and Mb mRNA content were not significantly changed. Under normoxia, the calculated interstitial oxygen tension required to prevent anoxic cores in muscle fibres (PO2crit) of high oxidative muscle fibres was between 1.0 and 1.7 mmHg. These values were similar at 3 and 6 weeks CCH. We conclude that high oxidative skeletal muscle fibres of zebrafish continue to grow and increase oxidative capacity during CCH. Oxygen supply to mitochondria in these fibres may be facilitated by an increased Mb concentration, which is regulated by an increase in Mb mRNA content per myonucleus.

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Size Principle of Striated Muscle Cells

Cited by 24 publications

References 0 publications

Ontogenetic changes in skeletal muscle fiber type, fiber diameter and myoglobin concentration in the Northern elephant seal (Mirounga angustirostris)

Ontogenetic changes in skeletal muscle fiber type, fiber diameter and myoglobin concentration in the Northern elephant seal (Mirounga angustirostris)

Blunted angiogenesis and hypertrophy are associated with increased fatigue resistance and unchanged aerobic capacity in old overloaded mouse muscle

Increased oxidative metabolism and myoglobin expression in zebrafish muscle during chronic hypoxia

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