Size-selective filtration of extracellular vesicles with a movable-layer device

Abstract

This paper presents a microfluidic device that can isolate extracellular vesicles (EVs) with multiple size intervals in a simple, effective, and automated manner. We accomplish this size-selective separation using a...

Recent microfluidic advances in submicron to nanoparticle manipulation and separation

“…187 (F) Size-selective filtration of EVs with a movable plunger and rotational chip. 224 (G) Microfluidic PFF for separation of exosomes and apoptotic bodies. 189…”

“…4(F). 224 The rotational chip has five filtration chambers with nanopore filters with pore diameters of 200 nm, 100 nm, 50 nm and 30 nm, respectively. These chambers are sequentially connected via check valves that allow unidirectional flow when the plunger moves downward to push the fluids.…”

“…(E) Integrated double-filtration microfluidic device for isolation of exosomes 187. (F) Size-selective filtration of EVs with a movable plunger and rotational chip 224. (G) Microfluidic PFF for separation of exosomes and apoptotic bodies 189.…”

Emerging integrated SERS-microfluidic devices for analysis of cancer-derived small extracellular vesicles

“…Some solutions to address this issue include application of electrophoretic force, a movable layer device, and cyclic tangential flow filtration. 39–42…”

“…Some solutions to address this issue include application of electrophoretic force, a movable layer device, and cyclic tangential flow filtration. [39][40][41][42] Deterministic lateral displacement (DLD). DLD is a microfluidic device with non-aligned pillar arrays which bifurcate the flow stream and shapes asymmetric streamlines around each pillar.…”