Sjögren‐Syndrom

André, Fiona; Böckle, Barbara C.

doi:10.1111/ddg.14823_g

Cited by 4 publications

(5 citation statements)

References 117 publications

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“…The study included patients with pSS treated at the First Affiliated Hospital of the University of Science and Technology of China from July 2019 to May 2023. The diagnosis of enrolled patients adhered to the classification criteria for pSS jointly established by the ACR and EULAR in 2016 [ 5 , 6 ]. This study has received approval from the Ethics Committee of the First Affiliated Hospital of the University of Science and Technology of China, with the ethics approval number: 2023-RE-279.…”

Section: Methodsmentioning

confidence: 99%

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The titers of antinuclear antibodies are associated with the degree of inflammation and organ damage in Primary Sjögren's Syndrome

Shao,

Wu,

Tao

et al. 2024

Clin Exp Med

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Primary Sjögren’s Syndrome (pSS) falls within the category of connective tissue diseases, characterized by the presence of autoantibodies such as antinuclear antibodies (ANA). However, according to the classification criteria for pSS, some patients may exhibit a negative result for autoantibodies. Patients with a negative result for autoantibodies may lack typical features of connective tissue diseases, and the immunological state as well as the extent of organ involvement and damage may differ from those with positive autoantibodies. This study aims to compare the clinical phenotypes of patients with positive and negative autoantibodies, providing insights for disease classification and treatment selection for clinicians. Patients with pSS were grouped based on the presence and titers of their autoantibodies. Subsequently, differences in organ damage and laboratory indicators were compared between these groups, aiming to analyze the value of autoantibody titers in assessing the condition of pSS. (1) Patients with positive ANA exhibited elevated levels of inflammatory indicators, including ESR, IgG levels, lip gland biopsy pathology grade, and overall organ involvement, in comparison with patients with negative ANA (P < 0.05). Furthermore, ANA-positivity correlated with a higher occurrence of multi-organ damage, particularly affecting the skin, mucous membranes, and the hematological system (P < 0.05). (2) As ANA titers increased, patients demonstrated elevated levels of IgG and an escalation in organ involvement (P < 0.05). (3) Patients in the positive autoantibody group (positive for antinuclear antibodies, anti-SSA, or anti-SSB antibodies) had higher IgG levels compared to the negative group (P < 0.05). (4) Patients with positive anti-SSA and anti-SSB antibodies exhibited higher levels of inflammatory indicators and IgG compared to other patients (P < 0.05); however, no significant differences were observed in terms of organ involvement and organ damage. Patients with positive ANA in pSS typically exhibit higher levels of inflammation and an increased likelihood of experiencing multi-organ damage. Furthermore, as the ANA titers increase, both inflammation levels and the risk of multi-organ damage also escalate. Additionally, the presence of anti-SSA and anti-SSB antibodies may contribute to an elevated risk of increased inflammation levels, but does not increase the risk of organ damage.

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Section: Methodsmentioning

confidence: 99%

“…However, in accordance with the classification (diagnostic) criteria for pSS established jointly by the ACR and EULAR in 2016, individuals suspected of having pSS with negative autoantibody tests can undergo additional lip biopsy. Positive biopsy results allow for the classification of these patients as having pSS [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

The titers of antinuclear antibodies are associated with the degree of inflammation and organ damage in Primary Sjögren's Syndrome

Shao,

Wu,

Tao

et al. 2024

Clin Exp Med

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“…About 11% of dry eye patients can be diagnosed with Sjögren’s syndrome ( 48 ), which is characterized by swelling of lymphocytes in the lacrimal gland and conjunctiva, T lymphocyte attack with meibomian gland shedding, and mucin defense ( 49 ). In patients with Sjögren’s syndrome, antigen-antibody reaction may occur in the corneal stroma, inducing inflammation and causing collagen dissolution and corneal mechanobiology destruction ( 50 ). In patients with Sjögren’s syndrome complicated with dry eye, the positive rate of cornea staining is higher than in ordinary patients with dry eye.…”

Section: Common Dry Eye Factorsmentioning

confidence: 99%

Inflammation mechanism and anti-inflammatory therapy of dry eye

Chu,

Wang,

Zhou

2024

Front. Med.

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Dry eye is a widespread chronic inflammatory disease that causes fatigue, tingling, burning, and other symptoms. Dry eye is attributed to rheumatic diseases, diabetes, hormone disorders, and contact lenses, which activate inflammatory pathways: mitogen-activated protein kinases (MAPK) and nuclear factor-B (NF-κB), promote macrophage inflammatory cell and T cell activation, and inflammation factors. Clinicians use a combination of anti-inflammatory drugs to manage different symptoms of dry eye; some of these anti-inflammatory drugs are being developed. This review introduces the dry eye inflammation mechanisms and the involved inflammatory factors. We also elucidate the anti-inflammatory drug mechanism and the detection limits.

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“…In Sjögren’s syndrome, a chronic autoimmune disorder of the exocrine glands, the epithelial cells produce pro‐inflammatory cytokines, which leads to impaired function of the salivary glands [ 99 ]. The application of UCMSCs in SS mouse models demonstrated that inflammation decreased and SS-like symptoms were alleviated [ 32 – 34 ].…”

Section: The Application Of Stem Cells For Orofacial Soft Tissue Defectsmentioning

confidence: 99%

Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing

Wang,

Knight,

Stephens

et al. 2023

Stem Cell Res Ther

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Orofacial soft tissue wounds caused by surgery for congenital defects, trauma, or disease frequently occur leading to complications affecting patients' quality of life. Scarring and fibrosis prevent proper skin, mucosa and muscle regeneration during wound repair. This may hamper maxillofacial growth and speech development. To promote the regeneration of injured orofacial soft tissue and attenuate scarring and fibrosis, intraoral and extraoral stem cells have been studied for their properties of facilitating maintenance and repair processes. In addition, the administration of stem cell-derived extracellular vesicles (EVs) may prevent fibrosis and promote the regeneration of orofacial soft tissues. Applying stem cells and EVs to treat orofacial defects forms a challenging but promising strategy to optimize treatment. This review provides an overview of the putative pitfalls, promises and the future of stem cells and EV therapy, focused on orofacial soft tissue regeneration.

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Sjögren‐Syndrom

Cited by 4 publications

References 117 publications

The titers of antinuclear antibodies are associated with the degree of inflammation and organ damage in Primary Sjögren's Syndrome

The titers of antinuclear antibodies are associated with the degree of inflammation and organ damage in Primary Sjögren's Syndrome

Inflammation mechanism and anti-inflammatory therapy of dry eye

Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing

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