Sjögren syndrome overlapping with ANCA-associated vasculitis: Four additional cases and systematic literature review

Coustal, Cyrille; Guillope, Béatrice; Serrand, Chris; Morel, Jacques; Taïeb, Guillaume; Castille, Elodie; Meliani, Kaoutar; Darmon, Olivier; Goulabchand, Radjiv; Guilpain, Philippe

doi:10.1016/j.autrev.2022.103099

Cited by 6 publications

(4 citation statements)

References 25 publications

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“…Es de resaltar que 5% de los pacientes con SS pueden tener anticentrómero (19). Del otro lado la población con VAA de la revisión fue en gran parte femenina (82%) (8), contrario al caso.…”

Section: Discussionunclassified

“…Las enfermedades reumáticas autoinmunes sistémicas (ERAS), pueden presentarse de manera simultánea con otras enfermedades del tejido conectivo (8,9). Para el caso de las VAA la superposición se ha demostrado con otras enfermedades inflamatorias y autoinmunes, como la enfermedad inflamatoria intestinal (10), enfermedad relacionada con IgG4 (IgG4-RD) (11), esclerosis sistémica, lupus eritematoso sistémico (9) y según lo publicado recientemente con este aportamos a la literatura el caso número 45 con síndrome de Sjögren (SS) (8,12).…”

Section: Introductionunclassified

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Síndrome de Sjögren con superposición con granulomatosis con poliangeitis

Fernández¹,

Martínez²

2023

Acta Med Col

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Las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilos se presentan por inflamación de los vasos sanguíneos, lesión endotelial y daño tisular que llevan a compromiso orgánico. La superposición con otras enfermedades reumáticas autoinmunes sistémicas es infrecuente. Se presenta el caso de un paciente que tuvo compromiso ocular, de vía respiratoria alta, pulmonar y renal producto de una vasculitis de pequeño vaso por autoanticuerpos contra las proteínas de los neutrófilos leucocitos proteinasa 3, que además se diagnosticó con Síndrome de Sjögren, coexistencia que es especialmente rara

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Section: Discussionunclassified

Section: Introductionunclassified

Síndrome de Sjögren con superposición con granulomatosis con poliangeitis

Fernández¹,

Martínez²

2023

Acta Med Col

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“…In individuals with granulomatosis with polyangiitis, AAV was most commonly associated with renal involvement (35/44 patients, 79.5%), with anti-MPO antibodies being the most common. Raynaud phenomenon and related auto-immune illnesses were found to be considerably more common in the non-granulomatous AAV group [ 133 ]. Multiple other studies supported this claim, stating that AAV not uncommonly occurs with Sjogren’s syndrome [ 134 ].…”

Section: Autoimmune and Rheumatic Diseases During Auto13: (Diseases 1–9)mentioning

confidence: 99%

The mosaic of autoimmunity – Finally discussing in person. The 13th international congress on autoimmunity 2022 (AUTO13) Athens

Mahroum

Elsalti

Alwani

et al. 2022

Autoimmunity Reviews

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“…Polyautoimmunity in AAV patients’ is not fully elucidated [ 12 ]. There are case reports of patients with AAV who have been diagnosed with other than AAV AID including RA [ 13 ], SLE [ 14 ], Sjögren’s syndrome [ 15 ] and scleroderma [ 16 ]. Martín-Nares in his publication [ 12 ] described the link between AAV and other immune-mediated conditions.…”

Section: Introductionmentioning

confidence: 99%

Co-existence of ANCA–associated vasculitides with immune-mediated diseases: a single-center observational study

Masiak,

Jassem,

Dębska-Ślizień

et al. 2024

Rheumatol Int

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Background Antineutrophil cytoplasmic antibody-associated vasculitides (AAV) is a group of systemic necrotizing small vessel autoimmune diseases, with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) being the two most common. The co-existence of AAV with different immune-mediated diseases (autoimmune disesases - AID) might affect the clinical presentation of the primary disease. The purpose of the study was to assess the co-existence of AAV with AID and to investigate whether it affects the characteristics and the course of AAV. Methods A retrospective single-center study was performed to identify patients with a diagnosis of MPA or GPA and concomitant AID, and to investigate their clinical features and characteristics. The group consisted of consecutive unselected AAV patients treated at a large university-based hospital, since 1988 with follow-up until 2022. Results Among 284 patients diagnosed either with GPA (232) or MPA (52), 40 (14,1%) had co-existing AIDs. The most frequent were: Hashimoto thyroiditis (16 cases), rheumatoid arthritis (8 cases), followed by psoriasis (6 cases), pernicious anemia (3 cases), and alopecia (3 cases). Patients with autoimmune comorbidities had a significantly longer time between the onset of symptoms and the diagnosis (26 vs. 11 months, p < 0.001). Laryngeal involvement (20.0% vs. 9.0%, p = 0,05), peripheral nervous system disorders (35.0% vs. 13.9%, p < 0.001), and neoplasms (20.0% vs. 8.6%, p = 0,044) were more common in patients with AID comorbidities, compared to subjects without AID. In contrast, renal involvement (45.0% vs. 70.9%, p = 0.001) and nodular lung lesions (27.5% vs. 47.5%, p = 0.044) were significantly less frequent in patients with co-morbidities. Following EUVAS criteria, patients with autoimmune co-morbidities had a generalized form of the disease without organ involvement (52.5% vs. 27.2%, p = 0.007), while the others had a higher percentage of generalized form with organ involvement (38.3% vs. 20.0%, p = 0.007). Conclusions The coexistence of AAV with different autoimmune diseases is not common, but it might affect the clinical course of the disease. Polyautoimmunity prolonged the time to diagnosis, but the AAV course seemed to be milder. Particular attention should be paid to the increased risk of cancer in these patients. It also seems reasonable that AAV patients should receive a serological screening to exclude the development of overlapping diseases.

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Sjögren syndrome overlapping with ANCA-associated vasculitis: Four additional cases and systematic literature review

Cited by 6 publications

References 25 publications

Síndrome de Sjögren con superposición con granulomatosis con poliangeitis

Síndrome de Sjögren con superposición con granulomatosis con poliangeitis

The mosaic of autoimmunity – Finally discussing in person. The 13th international congress on autoimmunity 2022 (AUTO13) Athens

Co-existence of ANCA–associated vasculitides with immune-mediated diseases: a single-center observational study

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