Skeletal Effects of Zinc Deficiency in Growing Rats

Eberle, Julia; Schmidmayer, S; Erben, Reinhold G.; Stangassinger, M.; Hp, Roth

doi:10.1016/s0946-672x(99)80019-4

Cited by 105 publications

(74 citation statements)

References 35 publications

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“…Zn is an essential nutrient for life required for many aspects of fetal growth and plays important roles in both prenatal and postnatal bone development. In fact, studies examining effects of Zn deficiency in animal models have shown that mild to severe Zn deficiency disturbs skeletal growth and maturation (Eberle et al, 1999;Wang et al, 2002). Animals fed on Zn-deficient diets have impairment in growth plate chondrocyte proliferation (Rossi et al, 2001;Wang et al, 2002) and bone mass (Eberle et al, 1999).…”

Section: Fig1: Lateral View Of the 20-days-old Fetuses Showing The Crmentioning

confidence: 99%

“…In fact, studies examining effects of Zn deficiency in animal models have shown that mild to severe Zn deficiency disturbs skeletal growth and maturation (Eberle et al, 1999;Wang et al, 2002). Animals fed on Zn-deficient diets have impairment in growth plate chondrocyte proliferation (Rossi et al, 2001;Wang et al, 2002) and bone mass (Eberle et al, 1999). Bone formation in Zn-deficient animals is also characterized by retarded growth plate activity and is associated with reduced cancellous and trabecular volume (Oner et al, 1984;Rossi et al, 2001).…”

Section: Fig1: Lateral View Of the 20-days-old Fetuses Showing The Crmentioning

confidence: 99%

See 1 more Smart Citation

Effect of in Utero Cadmium and/or Zinc Exposure on Occurrence of Squeletal Abnormalities.

Boughammoura¹,

Chemek²,

Mimouna³

et al. 2016

IJAR

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Section: Fig1: Lateral View Of the 20-days-old Fetuses Showing The Crmentioning

confidence: 99%

Section: Fig1: Lateral View Of the 20-days-old Fetuses Showing The Crmentioning

confidence: 99%

Effect of in Utero Cadmium and/or Zinc Exposure on Occurrence of Squeletal Abnormalities.

Boughammoura¹,

Chemek²,

Mimouna³

et al. 2016

IJAR

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“…The low intracellular zinc ion availability occurs despite the plasma zinc levels may be in the normal range, suggesting that the determination of plasma zinc can be misleading to detect a real zinc Mocchegiani et al (1998), Dardenne (2002), Bogden (2004), Haase et al (2006b), andPrasad (2008) Impairment of the immune response (cell-mediated immunity and humoral immunity) and impairment of thymic and extrathymic T cell pathways (NKT cell number and function) Eberle et al (1999) Abnormalities in bone growth and bone formation and mineralisation…”

Section: Dietary Zinc Deficienciesmentioning

confidence: 99%

Zinc: dietary intake and impact of supplementation on immune function in elderly

Mocchegiani

Romeo

Malavolta

et al. 2012

AGE

158

119

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The diet in the elderly does not provide a sufficient level of nutrients needed to maintain an adequate healthy status leading to micronutrient deficiencies and impaired immune response with subsequent development of degenerative diseases. Nutrient "zinc" is a relevant micronutrient involved in maintaining a good integrity of many body homeostatic mechanisms, including immune efficiency, owing to its requirement for the biological activity of many enzymes, proteins and for cellular proliferation and genomic stability. Old people aged 60-65 years and older have zinc intakes below 50% of the recommended daily allowance on a given day. Many causes can be involved: among them, altered intestinal absorption, inadequate mastication, psychosocial factors, drugs interactions, altered subcellular processes (zinc transporters (Zip and ZnT family), metallothioneins, divalent metal transporter-1). Zinc supplementation may remodel the immune alterations in elderly leading to healthy ageing. Several zinc trials have been carried out with contradictory data, perhaps due to incorrect choice of an effective zinc supplementation in old subjects showing subsequent zinc toxic effects on immunity. Old subjects with specific IL-6 polymorphism (GG allele carriers; named C−) are more prone for zinc supplementation than the entire old population, in whom correct dietary habits with foods containing zinc (Mediterranean diet) may be sufficient in restoring zinc deficiency and impaired immune response. We summarise the main causes of low zinc dietary intake in elderly reporting an update on the impact of zinc supplementation upon the immune response also on the basis of individual IL-6 polymorphism.

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“…In vitro studies have emphasized that Zn plays a role in the inhibition of bone resorption by inhibiting osteoclast-like cell formation (Kishi & Yamaguchi, 1994). In animals, Zn deficiency has been associated with abnormalities in bone growth, bone formation, and mineralization (Eberle et al, 1999). Zn intake has been reported to be associated with low bone mass in women (Angus et al, 1988).…”

Section: Zn and Bone Metabolismmentioning

confidence: 99%

Importance of zinc in the elderly: the ZENITH study

Meunier

O’Connor

Maiani³

et al. 2005

Eur J Clin Nutr

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The elderly are at nutritional risk as a result of multiple physiological, social, psychological, and economic factors. Physiological functions naturally decline with age, which may influence absorption and metabolism. Social and economic conditions can adversely affect dietary choices and eating patterns. However, at the same time, the nutrient needs of the elderly for certain nutrient (such as vitamins, minerals, proteins) is higher than for younger adults. This article reviews the importance of zinc (Zn) in elderly people, particularly for behavioural and mental function, micronutrient status, immune and antioxidant system, and bone metabolism.

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Skeletal Effects of Zinc Deficiency in Growing Rats

Cited by 105 publications

References 35 publications

Effect of in Utero Cadmium and/or Zinc Exposure on Occurrence of Squeletal Abnormalities.

Effect of in Utero Cadmium and/or Zinc Exposure on Occurrence of Squeletal Abnormalities.

Zinc: dietary intake and impact of supplementation on immune function in elderly

Importance of zinc in the elderly: the ZENITH study

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