Skeletal Manifestations of Hyperparathyroidism

Khedr, Ahmed

doi:10.5772/intechopen.74034

Cited by 5 publications

(3 citation statements)

References 130 publications

(181 reference statements)

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“…"PTH can produce catabolic or anabolic effect(s) on bone metabolism depending on the level of the hormone, periodicity, and duration of exposure". [48] Loss of healthy bone in cancer is found in combination with increases in abnormal bone deposits, or osteoblastic skeletal lesions [49,50]. Abnormal calcification of bone is seen in metastasis of the breast, prostate, and other cancers [51].…”

Section: Bone Remodeling and Dysregulated Phosphate Metabolismmentioning

confidence: 99%

Breast Cancer and Bone Mineral Density in a U.S. Cohort of Middle-Aged Women: Associations with Phosphate Toxicity

Brown,

Bigelow,

Dubin

2023

Cancers

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Breast cancer is associated with phosphate toxicity, the toxic effect from dysregulated phosphate metabolism that can stimulate tumorigenesis. Phosphate toxicity and dysregulated phosphate metabolism are also associated with bone mineral abnormalities, including excessive bone mineral loss and deposition. Based on shared associations with dysregulated phosphate metabolism and phosphate toxicity, a hypothesis proposed in the present mixed methods–grounded theory study posits that middle-aged women with incidence of breast cancer had a greater magnitude of changes in bone mineral density over time compared with women who remained cancer-free. To test this hypothesis, a mixed-effects model was used to analyze the associations of breast cancer incidence with spinal bone mineral density changes in the U.S. Study of Women’s Health Across the Nation. Compared with women in the cohort who remained cancer-free, women who self-reported breast cancer had higher bone mineral density at baseline, but had more rapid losses in bone mineral density during follow-up visits. These findings agree with the hypothesis that a greater magnitude of changes in bone mineral density over time is associated with breast cancer in a cohort of middle-aged women. The findings also have implications for studies investigating dysregulated phosphate metabolism and phosphate toxicity as causative factors of bone metastasis in metastatic breast cancer. Additionally, the authors previously found increased breast cancer risk associated with high dietary phosphate intake in the same cohort of middle-aged women, and more studies should investigate a low-phosphorus diet to reduce bone mineral abnormalities and tumorigenesis in breast cancer patients.

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Section: Bone Remodeling and Dysregulated Phosphate Metabolismmentioning

confidence: 99%

Breast Cancer and Bone Mineral Density in a U.S. Cohort of Middle-Aged Women: Associations with Phosphate Toxicity

Brown,

Bigelow,

Dubin

2023

Cancers

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“…The main function of hormone is to maintain calcium levels within the normal range thorough its action on the bone, kidneys, and intestine. It also decreases serum phosphorous through inhibiting renal reabsorption (12).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of vitamin D3, calcium and parathyroid hormone among women with osteoporosis in Wasit Province, Iraq

Ali¹,

AL-Attabi²

2022

ijhs

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Background: Osteoporosis (OP) is one of the most common metabolic diseases, characterized by low bone mass and abnormal bone microarchitecture leading to the development of fractures and subsequent disability. Disruption of bone remodeling by osteoporosis results in an imbalance between bone formation by osteoblasts and resorption by osteoclasts. Aims: This study was aimed to investigate relationship between vitamin D3, calcium and PTH, with estimating their effects on osteoporosis in women and the benefits in diagnosis. Materials and method: In this study, 50women who were referred to DEXA unit in Al-Karama Teaching Hospital to diagnosed with Osteoporosis. They were compared with 40 healthy individuals who did not have any clinical symptoms. Blood samples were used after separating them by a centrifuge for the purpose of examining levels of vital indicators were detected by Enzyme linked immunosorbent assay (ELISA). Results: The results of the current study showed a decrease in the level of Vitamin D3 and calcium, increasing in the levels of Parathyroid hormone, with significant differences between the study groups at P≤0.0001 compared to the control group.

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“…Hyperparathyroidism is an endocrine disorder related to excessive parathyroid hormone production (Bennett et al, 2020). Its manifestations in bone were first described by von Recklinghausen in 1891 (Khedr, 2018). Parenthetically, von Recklinghausen was quite productive, and there are several diseases to which his eponym has been attached (Magalini, 1971, pp.…”

Section: Introductionmentioning

confidence: 99%

The bare bones appearance of hyperparathyroidism: Distinguishing subperiosteal bone resorption from periosteal reaction

Rothschild

2021

Intl J of Osteoarchaeology

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Skeletal Manifestations of Hyperparathyroidism

Cited by 5 publications

References 130 publications

Breast Cancer and Bone Mineral Density in a U.S. Cohort of Middle-Aged Women: Associations with Phosphate Toxicity

Breast Cancer and Bone Mineral Density in a U.S. Cohort of Middle-Aged Women: Associations with Phosphate Toxicity

Evaluation of vitamin D3, calcium and parathyroid hormone among women with osteoporosis in Wasit Province, Iraq

The bare bones appearance of hyperparathyroidism: Distinguishing subperiosteal bone resorption from periosteal reaction

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