Skeletal Muscle: A Significant Novel Neurohypophyseal Hormone-Secreting Organ

Adamo, Sergio; Pigna, Eva; Lugarà, Rosamaria; Moresi, Viviana; Coletti, Dario; Bouché, Marina

doi:10.3389/fphys.2018.01885

Cited by 16 publications

(11 citation statements)

References 38 publications

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“…In association with the body's immune functions, OXT has been recognized to maintain immune surveillance, defense, and homeostasis through many approaches . The insufficient OXT and dysfunctions of OXTR signaling are likely associated with varieties of immune lesions, including carcinogenesis (Hou et al, 2016;Adamo et al, 2018). Our present findings further support this view by presenting the reduced expressions of OXT and OXTR in CAC tissues and by the suppressive effects of exogenous OXT on the expression of CRC metastasis-associated proteins, FAPα and CCL-2.…”

Section: Protective Effects Of Oxt and Oxtr Signaling In Colon Tissuesupporting

confidence: 85%

Oxytocin Inhibition of Metastatic Colorectal Cancer by Suppressing the Expression of Fibroblast Activation Protein-α

Chen

et al. 2019

Front. Neurosci.

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Oxytocin (OXT) and its receptor (OXTR) are present in the gastrointestinal system and are involved in gastrointestinal tumorigenesis. However, the effect of OXTR signaling on the development of colorectal cancer (CRC) and its underlying mechanisms remain unexplored. To address these issues, we first examined the expressions of OXT, OXTR, and several cancer-associated proteins using colon "tissue chips" from a spectrum of malignant progression of the colon, which included normal colon tissue, chronic colitis, colorectal adenoma, and colorectal adenocarcinoma (CAC). The results showed that the expressions of OXT and OXTR decreased gradually with the malignant progression of the disease. Stimulation of CAC tissues with OXT increased OXTR expression while down-regulated FAPα and CCL-2 protein expressions in a concentration-and timedependent manner. Moreover, cell invasion experiment showed that OXT treatment reduced the invasion ability of colon cancer cells and blocking OXTR with atosiban blocked OXT-reduced invasion ability of human colon cancer cell lines Ls174T and SW480. The results indicate that OXT has the potential to inhibit CRC development via down-regulating the immunosuppressive proteins FAPα and CCL-2. When the OXTR signaling is weakened, colon tissues may transform to CRC. These findings also highlight the possibility of applying OXT to inhibit CRC development directly.

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Section: Protective Effects Of Oxt and Oxtr Signaling In Colon Tissuesupporting

confidence: 85%

Oxytocin Inhibition of Metastatic Colorectal Cancer by Suppressing the Expression of Fibroblast Activation Protein-α

Chen

et al. 2019

Front. Neurosci.

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“…Third, oxytocin, which is mainly synthesized by the hypothalamic paraventricular and supraoptic nucleus, is expressed in myogenic cells and may have a protective role in patients with postcardiac arrest syndrome. In a recent experimental study, muscle tissue was considered a source of oxytocin [ 25 ]. Oxytocin has anti-inflammatory, antiapoptotic, and antioxidant properties that alleviate pathophysiological changes after ischemia–reperfusion in various human organs, including the bladder and heart.…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Estimated Lean Body Mass for Neurological Outcomes after Out-of-Hospital Cardiac Arrest

Lee

Kim

Chae

et al. 2020

JCM

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Background: Postcardiac arrest patients with a return of spontaneous circulation (ROSC) are critically ill, and high body mass index (BMI) is ascertained to be associated with good prognosis in patients with a critically ill condition. However, the exact mechanism has been unknown. To assess the effectiveness of skeletal muscles in reducing neuronal injury after the initial damage owing to cardiac arrest, we investigated the relationship between estimated lean body mass (LBM) and the prognosis of postcardiac arrest patients. Methods: This retrospective cohort study included adult patients with ROSC after out-of-hospital cardiac arrest from January 2015 to March 2020. The enrolled patients were allocated into good- and poor-outcome groups (cerebral performance category (CPC) scores 1–2 and 3–5, respectively). Estimated LBM was categorized into quartiles. Multivariate regression models were used to evaluate the association between LBM and a good CPC score. The area under the receiver operating characteristic curve (AUROC) was assessed. Results: In total, 155 patients were analyzed (CPC score 1–2 vs. 3–5, n = 70 vs. n = 85). Patients’ age, first monitored rhythm, no-flow time, presumed cause of arrest, BMI, and LBM were different (p < 0.05). Fourth-quartile LBM (≥48.98 kg) was associated with good neurological outcome of postcardiac arrest patients (odds ratio = 4.81, 95% confidence interval (CI), 1.10–25.55, p = 0.04). Initial high LBM was also a predictor of good neurological outcomes (AUROC of multivariate regression model including LBM: 0.918). Conclusions: Initial LBM above 48.98kg is a feasible prognostic factor for good neurological outcomes in postcardiac arrest patients.

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“…Increased expression of OT in livestock as a result of anabolizing treatments was reported by other groups. 14 Interestingly, the estrogen control of OT expression appears to be mediated by ERR, an effect which can be further amplified by an OT/OT-R loop. 14 Furthermore, physical activity was shown to physiologically stimulate AVP and OT secretion.…”

Section: Skeletal Muscle Is a Source Of Avp And Otmentioning

confidence: 99%

“…14 Interestingly, the estrogen control of OT expression appears to be mediated by ERR, an effect which can be further amplified by an OT/OT-R loop. 14 Furthermore, physical activity was shown to physiologically stimulate AVP and OT secretion. Several groups demonstrated that exercise results in increased levels of AVP and OT in the hypothalamus as well as in plasma.…”

Section: Skeletal Muscle Is a Source Of Avp And Otmentioning

confidence: 99%

“…Several groups demonstrated that exercise results in increased levels of AVP and OT in the hypothalamus as well as in plasma. 14 Exercise plays beneficial effects on muscle physiology. The exercise-mediated stimulation of AVP and OT suggests that physical activity participates in their autocrine effect upon skeletal muscle triggering NH secretion by muscle and brain, thus regulating their receptors and contributing to muscle homeostasis.…”

Section: Skeletal Muscle Is a Source Of Avp And Otmentioning

confidence: 99%

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Neurohypophyseal hormones and skeletal muscle: a tale of two faces

et al. 2020

Self Cite

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The neurohypophyseal hormones vasopressin and oxytocin were invested, in recent years, with novel functions upon striated muscle, regulating its differentiation, trophism, and homeostasis. Recent studies highlight that these hormones not only target skeletal muscle but represent novel myokines. We discuss the possibility of exploiting the muscle hypertrophying activity of oxytocin to revert muscle atrophy, including cancer cachexia muscle wasting. Furthermore, the role of oxytocin in cardiac homeostasis and the possible role of cardiac atrophy as a concause of death in cachectic patients is discussed.

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Skeletal Muscle: A Significant Novel Neurohypophyseal Hormone-Secreting Organ

Cited by 16 publications

References 38 publications

Oxytocin Inhibition of Metastatic Colorectal Cancer by Suppressing the Expression of Fibroblast Activation Protein-α

Oxytocin Inhibition of Metastatic Colorectal Cancer by Suppressing the Expression of Fibroblast Activation Protein-α

Predictive Value of Estimated Lean Body Mass for Neurological Outcomes after Out-of-Hospital Cardiac Arrest

Neurohypophyseal hormones and skeletal muscle: a tale of two faces

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