Skeletal Muscle Calcium Metabolism and Contractile Force in Vitamin D-deficient Chicks

Pleasure, David E; Wyszynski, Bernard; Sumner, A. T.; Schotland, Donald L.; Фельдман, Б В; Nugent, N. A.; Hitz, K.; Goodman, David B. P.

doi:10.1172/jci109569

Cited by 92 publications

(64 citation statements)

References 51 publications

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“…In agreement with other reports in humans (3) and chicks (14) we found normal ATP levels along with mildly decreased creatine phosphate levels in vitamin D-deficient animals. Young et al (3) feel that the modest decreases in creatine phosphate levels seen in vitamin D deficiency could not explain the myopathy seen in this condition.…”

Section: Discussionsupporting

confidence: 93%

“…Recently, in in vitro studies, calcium has also been shown to have a direct effect on muscle protein turnover rates (12,13). Vitamin D administration increases plasma calcium levels, improves force generation by muscle, affects the secretion of other hormones, and is associated with increased food intake (5,(14)(15)(16). In addition, a direct anabolic effect within muscle has been suggested for one vitamin D metabolite.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D Deficiency, hypocalcemia, and increased skeletal muscle degradation in rats.

Wassner¹,

Li²,

Sperduto³

et al. 1983

J. Clin. Invest.

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A B S T R A C T The myopathy associated with vitamin D deficiency was examined in vitamin D-deficient and vitamin D-supplemented rats. When compared with either vitamin D-supplemented ad lib. or pair-fed rats, weight gain and muscle mass were decreased in vitamin D-deficient hypocalcemic animals. With the exception of a modest decrease in muscle creatine phosphate levels, muscle composition was unchanged by vitamin D deficiency. Muscle protein turnover rates were determined in both in vivo and in vitro studies and demonstrated that myofibrillar protein degradation was increased in vitamin D deficiency. Normal growth rates could be maintained be feeding the rats vitamin D-deficient diets containing 1.6% calcium, which maintained plasma calcium within the normal range. In addition to its role in maintaining plasma calcium, vitamin D-supplemented rats had significantly higher levels of the anabolic hormone insulin. Vitamin D supplementation may affect muscle protein turnover by preventing hypocalcemia, as well as directly stimulating insulin secretion, rather than by a direct effect within skeletal muscle.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency, hypocalcemia, and increased skeletal muscle degradation in rats.

Wassner¹,

Li²,

Sperduto³

et al. 1983

J. Clin. Invest.

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“…Vitamin D may act directly on muscle tissue to exert its preventive effect on falls. It has been known that osteomalacia and rickets cause muscular atrophy and decrease muscle strength and that the muscular symptoms associated with these diseases quickly improve with vitamin D treatment (39,43). These findings indicate a potential association between vitamin D and muscle tissue.…”

mentioning

confidence: 83%

Effects of alfacalcidol on muscle strength, muscle fatigue, and bone mineral density in normal and ovariectomized rats

et al. 2010

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Vitamin D affects not only bone but also muscle to prevent falls and osteoporotic fractures. However, these effects on muscle and the mechanisms of fall prevention are still unclear. The purpose of this study was to investigate the effects of alfacalcidol [1α(OH)D 3 ] on muscle strength, muscle fatigue, and bone mineral density (BMD) in ovariectomized rats. Seven-month-old female Wistar rats were orally administered 1α(OH)D 3 or its vehicle everyday for 4 weeks after ovariectomy (OVX) or sham operation. Calf muscle strength and fatigue were evaluated by electrical stimulation of the sciatic nerve under general anesthesia. 1α(OH)D 3 administration significantly increased the maximum muscle strength in the sham-operated (P < 0.01) and the OVX (P < 0.01) groups compared to their respective control groups. However, 1α(OH)D 3 administration did not significantly affect muscle fatigue in these groups. The BMD of the femur in the 1α(OH)D 3 -treated OVX group was significantly higher than that in the vehicle-treated OVX group (P = 0.04). These results suggested that 1α(OH)D 3 increases muscle strength but does not affect muscle fatigue in this rat model. The effectiveness of activated vitamin D in preventing bone fractures may be partly owing to its effect on muscle strength in addition to its known effect on bone metabolism.The active, hormonal form of vitamin D 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 or calcitriol] and its prodrug 1α-hydroxyvitamin D 3 [1α(OH)D 3 or alfacalcidol] have been widely used to treat a variety of metabolic bone diseases, such as rickets/osteomalacia, renal osteodystrophy, and osteoporosis (8, 41). Activated vitamin D can prevent fractures by improving bone quality, bone metabolism, and bone mineral density (BMD) (7,22,40,45,50). However, its preventive effects on fractures were more significant than its effects on bone quality or BMD. Several recent meta-analyses have demonstrated that native or activated vitamin D has preventive effects on falls (2, 16). This preventive effect on falls contributes to a partial reduction of fractures by vitamin D in elderly osteoporotic individuals (3, 37). However, the mechanisms by which activated vitamin D prevents falls remain unknown. Several factors have been reported as physical risk factors for falls, including decreased muscle strength or function of lower extremity, impaired physical function such as single-leg standing, and postural imbalance with aging (26,28,34,36). Vitamin D may act directly on muscle tissue to exert its preventive effect on falls. It has been known that osteomalacia and rickets cause muscular atrophy and decrease muscle strength and that the muscular symptoms associated with these diseases quickly improve with vitamin D treatment (39, 43). These findings indicate a potential association between vitamin D and muscle tissue. Therefore, the effects of vitamin D on muscle tissue with regard to fall prevention have been of focus in aged and osteoporotic patients. Muscle function is defined by several factors, including mu...

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“…This is mainly due to the muscular weakness which is predominant in these patients and which appears mainly in the lower extremities, particularly in the proximal muscles. Uraemic muscle has been found to have an increased protein catabolism and decreased protein synthesis, insulin resistance with glucose intolerance, and hyperinsulinaemia [11, 12, 13]as well as an impaired ability to activate vitamin D which in turn affects the actomyosin-troponin system, causing a reduced tension and relaxation of skeletal muscles during repetitive stimulation [14]. All these factors may contribute to uraemic muscle weakness.…”

Section: Introductionmentioning

confidence: 99%

Twelve Weeks of Exercise TrainingIncreases Muscle Function and Walking Capacity in Elderly Predialysis Patients and Healthy Subjects

Heiwe

Tollbäck

Clyne

2001

Nephron

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Muscle function declines with age and progressive uraemia. We examined whether elderly predialysis patients could improve thigh muscle function, walking capacity, and functional mobility to the same extent as elderly healthy subjects when participating in 12 weeks of individual muscle endurance exercises for the thigh as well as in a low-intensive group programme. The uraemic exercise and comparison groups comprised 16 patients (age 76 ± 7 years, glomerular filtration rate 18 ± 5 ml/min) and 9 patients (age 72 ± 6 years, glomerular filtration rate 16 ± 5 ml/min), respectively. The healthy exercise and comparison groups comprised 18 subjects (age 75 ± 7 years) and 5 subjects (age 79 ± 4 years), respectively. Muscular strength, dynamic endurance, walking capacity, and functional mobility increased significantly in both the uraemic and the healthy exercise groups after 12 weeks of regular muscle endurance exercise training, whereas there was no significant change in static muscle endurance and quality of life in either group. None of the values changed for the uraemic comparison group nor the healthy comparison group during the observation period. Elderly predialysis patients had lower muscle function and mobility as compared with elderly healthy subjects, but were able to improve both after 12 weeks of exercise training to the same extent as elderly healthy subjects.

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Skeletal Muscle Calcium Metabolism and Contractile Force in Vitamin D-deficient Chicks

Abstract: A B S T R A C T

Cited by 92 publications

References 51 publications

Vitamin D Deficiency, hypocalcemia, and increased skeletal muscle degradation in rats.

Vitamin D Deficiency, hypocalcemia, and increased skeletal muscle degradation in rats.

Effects of alfacalcidol on muscle strength, muscle fatigue, and bone mineral density in normal and ovariectomized rats

Twelve Weeks of Exercise TrainingIncreases Muscle Function and Walking Capacity in Elderly Predialysis Patients and Healthy Subjects

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