Skeletal muscle metabolism is a major determinant of resting energy expenditure.

Zurlo, F.; Larson, K. A.; Bogardus, Clifton; Ravussin, Éric

doi:10.1172/jci114857

Cited by 823 publications

(607 citation statements)

References 15 publications

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“…An increase in these glycolytic type 2b fibers was found to occur over the lifespan, suggesting a gene -environment interaction on fiber type composition in human skeletal muscle. 20 In addition, differences in muscle biochemistry account for part of the inter-individual variability in muscle oxygen uptake and whole-body energy metabolism, 21 suggesting that skeletal muscle energetics may contribute to the variability of metabolic rate observed in people. Children inherit their muscle fiber typing from their parents.…”

Section: Introductionmentioning

confidence: 99%

Skeletal muscle energetics assessed by 31P-NMR in prepubertal girls with a familial predisposition to obesity

Herrick

2001

Int J Obes

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OBJECTIVE:To determine whether skeletal muscle energetics, measured by in vivo 31 P-nuclear magnetic resonance spectroscopy during plantar flexion exercise, differ between multiethnic, prepubertal girls with or without a predisposition to obesity. DESIGN: Cross-sectional study. SUBJECTS: Girls (mean age and body fat AE s.d. ¼ 8.6 AE 0.3 y and 22.6 AE 4.2%) were recruited according to parental leanness or obesity defined as follows: LN (n ¼ 22), two lean parents, LNOB (n ¼ 18), one lean and one obese parent; and OB (n ¼ 15), two obese parents. MEASUREMENTS: A 3 min, rest -exercise -recovery plantar flexion protocol was completed. Work was calculated from the force data. Spectra were analyzed for inorganic intracellular phosphate (P i ), phosphocreatine (PCr), P i =PCr (ratio of the low and high energy phosphates indicating the bioenergetic state of the cell), intracellular pH, and adenosine triphosphate (ATP). Magnetic resonance imaging was used to determine calf muscle volume. RESULTS: BMI was lower in the girls in the LN group (15.9 AE 1.5 kg=m 2 ) compared to the OB group (16.7 AE 1.3 kg=m 2 ) of girls (P < 0.05), with no difference with the LNOB group (16.7 AE 1.9 kg=m 2 ). Adjusted for muscle volume and cumulative work, no differences in P i , PCr, P i =PCr, pH, or ATP were observed among the LN, LNOB and OB groups at rest, the end of exercise, and after 60 and 300 s of recovery. From rest to the end of exercise, P i and P i =PCr (mean AE s.d.: 0.2 AE 0.1 vs 1.5 AE 1.0) increased, whereas PCr and pH (7.04 AE 0.06 vs 6.95 AE 0.10) decreased (all P < 0.001). By 60 s of recovery, P i and P i =PCr decreased, whereas PCr and pH increased (all P < 0.001). CONCLUSIONS: Skeletal muscle energetics, specifically P i =PCr and pH measured during plantar flexion exercise, do not differ between prepubertal girls with or without a familial predisposition to obesity.

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Section: Introductionmentioning

confidence: 99%

Skeletal muscle energetics assessed by 31P-NMR in prepubertal girls with a familial predisposition to obesity

Herrick

2001

Int J Obes

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“…The capacity to reduce coupling efficiency selectively in muscle or fat may allow a chemical uncoupler to be used in obesity treatment [11]. SKM, as a large organ and a major site of facultative thermogenesis, contributes significantly to resting EE (REE) [35]. WAT is a major site of energy storage and does not directly contribute a large amount to REE, but has the capacity to indirectly influence whole-body metabolic efficiency via a range of secreted regulatory factors (adipokines) [8,36,37].…”

Section: Discussionmentioning

confidence: 99%

A novel chemical uncoupler ameliorates obesity and related phenotypes in mice with diet-induced obesity by modulating energy expenditure and food intake

Zhang

Turner

et al. 2013

Diabetologia

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Aims/hypothesis Decreasing mitochondrial coupling efficiency has been shown to be an effective therapy for obesity and related metabolic symptoms. Here we identified a novel mitochondrial uncoupler that promoted uncoupled respiration in a cell type-specific manner and investigated its effects on modulation of energy metabolism in vivo and in vitro. Methods We screened a collection of mitochondrial membrane potential depolarising compounds for a novel chemical uncoupler on isolated skeletal muscle mitochondria using a channel oxygen system. The effect on respiration of metabolic cells (L6 myotubes, 3T3-L1 adipocytes and rat primary hepatocytes) was examined and metabolic pathways sensitive to cellular ATP content were also evaluated. The chronic metabolic effects were investigated in high-fat diet-induced obese mice and standard diet-fed (SD) lean mice.Results The novel uncoupler, CZ5, promoted uncoupled respiration in a cell type-specific manner. It stimulated fuel oxidation in L6 myotubes and reduced lipid accumulation in 3T3-L1 adipocytes but did not affect gluconeogenesis or the triacylglycerol content in hepatocytes. The administration of CZ5 to SD mice increased energy expenditure (EE) but did not affect body weight or adiposity. Chronic studies in mice on high-fat diet showed that CZ5 reduced body weight and improved glucose and lipid metabolism via both increased EE and suppressed energy intake. The reduced adiposity was associated with the restoration of expression of key metabolic genes in visceral adipose tissue. Conclusions/interpretation This work demonstrates that a cell type-specific mitochondrial chemical uncoupler may have therapeutic potential for treating high-fat diet-induced metabolic diseases.

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“…Em particular, a massa corporal magra, composta por músculos, vísceras, ossos e água, constitui o compartimento corporal com maior atividade metabólica e, por essa razão, é considerada um importante determinante do gasto energético, explicando 73% do GER e 80% do gasto ener-gético de total 17,18 . Já a gordura corporal, influencia o gasto energético em menor magnitude que a massa magra 14 .…”

Section: Fatores Que Afetam O Gasto Energéticounclassified

Gasto energético de repouso em pacientes com doença renal crônica

et al. 2008

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O conhecimento do gasto energético de repouso é de fundamental importância na determinação das necessidades energéticas e, conseqüentemente, no estabelecimento das recomendações de energia de um indivíduo. O elevado gasto energético, se não compensado por uma ingestão alimentar suficiente, poderá contribuir para a desnutrição e o maior risco de morbidade e mortalidade. Nos pacientes com doença renal crônica, a uremia per se e o tratamento de diálise estão, freqüentemente, associados a vários distúrbios, como a acidose metabólica, a resistência insulínica, o hiperparatireoidismo secundário e a inflamação, que podem aumentar o catabolismo protéico e, em parte, contribuir para o aumento do gasto energético de repouso. A presente revisão tem como objetivo descrever os estudos sobre o gasto energético de repouso nos pacientes com doença renal crônica e os aspectos que influenciam o gasto energético nesta população.

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Skeletal muscle metabolism is a major determinant of resting energy expenditure.

Cited by 823 publications

References 15 publications

Skeletal muscle energetics assessed by 31P-NMR in prepubertal girls with a familial predisposition to obesity

Skeletal muscle energetics assessed by 31P-NMR in prepubertal girls with a familial predisposition to obesity

A novel chemical uncoupler ameliorates obesity and related phenotypes in mice with diet-induced obesity by modulating energy expenditure and food intake

Gasto energético de repouso em pacientes com doença renal crônica

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