Skeletal muscle metastases on magnetic resonance imaging: analysis of 31 cases

Li, Qi; Wang, Lei; Pan, Shinong; Song, Hong; Ma, Ying; Lu, Zaiming; Xihu, Fu; Jiang, Bo; Guo, Qiyong

doi:10.5114/wo.2016.61568

Cited by 6 publications

(4 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Type-II diffuse lesions without bone destruction and are characterized by diffused swelling of muscle and slightly hypo- to iso-intensity in T1WI and hyperintensity in T2WI. Type-III diffuse lesions with bone destruction, characterized by irregular lumps with iso-intensity in T1WI and heterogeneous hyper-intensity in T2WI, with adjacent bone invasion [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Lung Adenocarcinoma Metastasis to the Tricep Muscle: Four Years Disease-Free After Surgical Resection and Radiotherapy

Weeraddana¹,

Walgamage²,

Elkabbani³

et al. 2023

Cureus

View full text Add to dashboard Cite

Lung cancer is one of the leading causes of cancer-related death worldwide. Lung cancer commonly metastasizes to the liver, bone, and brain, but metastasis to skeletal muscles is rare. The development of metastasis in skeletal muscles indicates stage IV disease with a poor prognosis. The most effective treatment strategy is unclear. Palliative radiotherapy is often used to treat skeletal muscle metastases, and patient survival is poor, with an average survival of one year. Here we discuss the case of a 76-year-old female diagnosed with lung adenocarcinoma with metastasis to the trapezius muscle. Initially, she was treated with stereotactic body radiotherapy for stage T1 lung adenocarcinoma. Her follow-up surveillance positron emission tomography (PET) scan in 11 months showed an abnormal focal area of increased activity localizing to the long head of the right triceps muscle. The diagnosis was confirmed with an ultrasound-guided biopsy of the trapezius muscle. Following that, the patient underwent wedge resection of the right middle and upper lobe of the lung and partial right trapezius resection. Afterward, she was given radiation therapy at the tricep resection site. She remained disease-free for four years after excision and radiation therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Lung Adenocarcinoma Metastasis to the Tricep Muscle: Four Years Disease-Free After Surgical Resection and Radiotherapy

Weeraddana¹,

Walgamage²,

Elkabbani³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…Li et al reported that soft tissue sarcoma, single haematoma, haemangioma or malignant fibrous histocytoma can mimic SMM in MRI. 11 Nevertheless, CT and MRI are sometimes not sufficient for screening all soft tissue tumours. PET-CT could provide additional diagnostic information to a greater extent than other staging examinations.…”

Section: Discussionmentioning

confidence: 99%

EML4-ALK positive lung adenocarcinoma with skeletal muscle metastasis in the right calf which was treatable with lorlatinib after resistance to treatment with alectinib

et al. 2021

View full text Add to dashboard Cite

This report concerns a patient with skeletal muscle metastases due to lung adenocarcinoma harbouring an echinoderm microtubule-associated protein-like-4 (EML4)-anaplastic lymphoma kinase (ALK) rearrangement, who was successfully treated with lorlatinib after resistance to alectinib. A right lower lobectomy based on a diagnosis of lung adenocarcinoma was performed on a 77-year-old Japanese woman. After 7 months of surgical resection, a mass in the right calf was observed. A fine-needle aspiration biopsy from the mass was performed and the mass was diagnosed as metastatic adenocarcinoma harbouring EML4-ALK rearrangement. Alectinib was administered for 10 months. Then, administration of lorlatinib, an ALK tyrosine kinase inhibitor classified as third generation, was initiated after resistance to treatment with alectinib. After starting treatment with lorlatinib, the gastrocnemius tumour diminished and has maintained a stable condition. Our case suggests that EML4-ALK positive lung adenocarcinoma is treatable with lorlatinib after resistance to treatment with alectinib.

show abstract

“…MRI is used for differential diagnosis and to analyze and compare the range of affected muscles to the surrounding muscles across several sections and angles. Li et al [ 24 ] performed MRI analysis on 31 patients with SMM. They found that most MRI images had heterogeneous iso-signals in T1W1, homogeneous high signals in T2W1, and heterogeneously enhanced signals in TT2W1.…”

Section: Discussionmentioning

confidence: 99%

Skeletal muscle metastases of hepatocellular carcinoma: A case report and literature review

Song¹,

Sun²,

Wu³

et al. 2021

WJCC

View full text Add to dashboard Cite

BACKGROUND The metastasis of liver cancer to skeletal muscle is extremely rare compared to other sites. We herein report a case of rapidly developing skeletal metastases following liver transplantation due to primary liver cancer. CASE SUMMARY A 70-year-old male with underlying chronic hepatitis B virus infection was diagnosed with hepatocellular carcinoma (HCC), for which he underwent liver transplantation in 2014. Six years after receiving the transplant, pathological examination confirmed the presence of HCC without vascular invasion. He was admitted to the hospital with a rapidly growing mass on his right thigh. Ultrasound examination revealed a mixed echo mass in the lateral soft tissue of the middle part of the right femur. Magnetic resonance imaging showed heterogeneous iso-signal intensity on T1-weighted images and heterogeneous hyper-intensity on T2-weighted images compared to the surrounding muscles. Pathological examination of the ultrasound-guided needle biopsy specimen revealed that it was similar to the previously detected liver cancer; the diagnosis was metastasis of HCC. Surgical excision was performed. There were no other sites of metastasis, and the patient recovered well after surgery. CONCLUSION This report presents a rare case of skeletal metastasis following liver transplantation for HCC. The study suggests a possible role for skeletal muscle metastasis mechanisms, which should be the focus of future research.

show abstract

Skeletal muscle metastases on magnetic resonance imaging: analysis of 31 cases

Cited by 6 publications

References 37 publications

An Unusual Case of Lung Adenocarcinoma Metastasis to the Tricep Muscle: Four Years Disease-Free After Surgical Resection and Radiotherapy

An Unusual Case of Lung Adenocarcinoma Metastasis to the Tricep Muscle: Four Years Disease-Free After Surgical Resection and Radiotherapy

EML4-ALK positive lung adenocarcinoma with skeletal muscle metastasis in the right calf which was treatable with lorlatinib after resistance to treatment with alectinib

Skeletal muscle metastases of hepatocellular carcinoma: A case report and literature review

Contact Info

Product

Resources

About