Skeletal Muscle Phosphocreatine Recovery after Submaximal Exercise in Children and Young and Middle-Aged Adults

Fleischman, Amy; Makimura, Hideo; Stanley, Takara L.; McCarthy, Meaghan A.; Kron, Matthew; Sun, Noelle; Chuzi, Sarah; Hrovat, Mirko I.; Systrom, David M.; Grinspoon, Steven

doi:10.1210/jc.2010-0527

Cited by 31 publications

(30 citation statements)

References 24 publications

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“…In a previous study, Fleischman and collaborators similarly tested the association between 31 P muscle bioenergetics and maximal voluntary contraction of the knee extensor muscle (Fleischman et al ., 2010). They found that this association was no longer significant when adjusted for age and covariates.…”

Section: Discussionmentioning

confidence: 99%

“…Studies conducted in animal models and in humans have shown that skeletal muscle mitochondrial oxidative capacity declines with age (Conley et al ., 2000; Short et al ., 2005; Fleischman et al ., 2010; Peterson et al ., 2012), likely due to a decline in both total mitochondrial mass and decreased intrinsic mitochondrial functional capacity (Conley et al ., 2000). This steady decline of mitochondrial function with aging is believed to contribute to the progressive deterioration of muscle strength and quality (Metter et al ., 1999), as diminished energy production may constrain muscle performance, and dysfunctional mitochondria create oxidative stress that can damage proteins and mitochondrial DNA (Peterson et al ., 2012).…”

Section: Introductionmentioning

confidence: 99%

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Muscle strength mediates the relationship between mitochondrial energetics and walking performance

et al. 2017

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SummarySkeletal muscle mitochondrial oxidative capacity declines with age and negatively affects walking performance, but the mechanism for this association is not fully clear. We tested the hypothesis that impaired oxidative capacity affects muscle performance and, through this mechanism, has a negative effect on walking speed. Muscle mitochondrial oxidative capacity was measured by in vivo phosphorus magnetic resonance spectroscopy as the postexercise phosphocreatine resynthesis rate, kPC r, in 326 participants (154 men), aged 24–97 years (mean 71), in the Baltimore Longitudinal Study of Aging. Muscle strength and quality were determined by knee extension isokinetic strength, and the ratio of knee extension strength to thigh muscle cross‐sectional area derived from computed topography, respectively. Four walking tasks were evaluated: a usual pace over 6 m and for 150 s, and a rapid pace over 6 m and 400 m. In multivariate linear regression analyses, kPC r was associated with muscle strength (β = 0.140, P = 0.007) and muscle quality (β = 0.127, P = 0.022), independent of age, sex, height, and weight; muscle strength was also a significant independent correlate of walking speed (P < 0.02 for all tasks) and in a formal mediation analysis significantly attenuated the association between kPC r and three of four walking tasks (18–29% reduction in β for kPC r). This is the first demonstration in human adults that mitochondrial function affects muscle strength and that inefficiency in muscle bioenergetics partially accounts for differences in mobility through this mechanism.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Muscle strength mediates the relationship between mitochondrial energetics and walking performance

et al. 2017

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“…This profile might explain the higher blood/muscle lactate and H + ion values obtained after maximal exercise in adolescents [2]. It could also be the cause of the slower recovery of some energy substrates (i.e., phosphocreatine) following exercise and the slower elimination of metabolites (i.e., lactate and H + ions) from the skeletal muscle in adolescents compared to children [23][24][25][26][27][28]. The lower oxidative profile of adolescents could therefore partly explain their slower recovery and their greater fatigability during repeated high-intensity exercise protocols.…”

Section: Energy Metabolismmentioning

confidence: 99%

Is There a Progressive Withdrawal of Physiological Protections against High-Intensity Exercise-Induced Fatigue during Puberty?

Ratel

Martín

2015

Sports

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Puberty is characterized by a large number of physiological modifications that translate into increased neuromuscular fatigue during high-intensity exercise in adolescents compared to prepubertal children. This greater neuromuscular fatigue in adolescents could be attributed to peripheral (i.e., muscular) and central (i.e., nervous) factors that change through puberty. Among the peripheral changes are muscle mass, fiber type composition, energy metabolism and musculo-tendinous stiffness. Among the central modifications are the voluntary activation level, the antagonist co-activation and a differential interplay between central and peripheral fatigue. The objective of this review article will be to underline the importance of these factors on the development of neuromuscular fatigue during high-intensity exercise throughout puberty and to highlight that the adolescents could be physiologically less protected against fatiguing high-intensity exercise than their prepubertal counterparts.

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“…Baseline data, but not longitudinal data, from this cohort have been published previously (10,11). Participants underwent a baseline evaluation, including a complete medical and family history; physical examination, including Tanner staging by a pediatric endocrinologist (A.F.…”

Section: Methodsmentioning

confidence: 99%

Skeletal Muscle Mitochondrial Function Is Associated with Longitudinal Growth Velocity in Children and Adolescents

McCormack¹,

McCarthy²,

Farilla³

et al. 2011

The Journal of Clinical Endocrinology & Metabolism

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Skeletal Muscle Phosphocreatine Recovery after Submaximal Exercise in Children and Young and Middle-Aged Adults

Abstract: Skeletal muscle PCr recovery measured by (31)phosphorous-MRS is prolonged with age, even in children and young adults.

Cited by 31 publications

References 24 publications

Muscle strength mediates the relationship between mitochondrial energetics and walking performance

Muscle strength mediates the relationship between mitochondrial energetics and walking performance

Is There a Progressive Withdrawal of Physiological Protections against High-Intensity Exercise-Induced Fatigue during Puberty?

Skeletal Muscle Mitochondrial Function Is Associated with Longitudinal Growth Velocity in Children and Adolescents

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