Skew Deviation: Case Report and Review of the Literature

Tudor, Katarina Ivana; Petravić, Damir; Jukić, Anđela; Juratovac, Zlatko

doi:10.3109/08820538.2016.1170164

Cited by 6 publications

(6 citation statements)

References 33 publications

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“…Experts, familiar with eye movement examinations, however, might not benefit as much as non-experts from an automated system, unless the automated skew test is part of a comprehensive battery of other vestibular tests integrated into one and the same device like the one we evaluated here. There are other clinical signs associated with skew deviation in dizzy patients such as ocular counterroll detected by fundoscopy, [19] subjective visual vertical, [17] the maddox rods, [18,19] or by the Hess-Lancaster test and Parks-Bielschowsky test [19]. Such additional tests performed by experts could add more diagnostic certainty in patients with suspected skew deviation.…”

Section: The Advantage Of Vog Skew Testingmentioning

confidence: 99%

Automated alternate cover test for ‘HINTS’ assessment: a validation study

Morrison

Kerkeni

Korda

et al. 2021

Eur Arch Otorhinolaryngol

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Objective The alternate cover test (ACT) in patients with acute vestibular syndrome is part of the ‘HINTS’ battery test. Although quantitative, the ACT is highly dependent on the examiner’s experience and could theoretically vary greatly between examiners. In this study, we sought to validate an automated video-oculography (VOG) system based on eye tracking and dedicated glasses. Methods We artificially induced a vertical strabismus to simulate a skew deviation on ten healthy subjects, aged from 26 to 66, using different press-on Fresnel prisms on one eye while recording eye position with VOG of the contralateral eye. We then compared the system’s performance to that of a blinded trained orthoptist using conventional, semi-quantitative method of skew measurement known as the alternate prism cover test (APCT) as a gold standard. Results We found a significant correlation between the reference APCT and the Skew VOG (Pearson’s R2 = 0.606, p < 0.05). There was a good agreement between the two tests (intraclass correlation coefficient 0.852, 95 CI 0.728–0.917, p < 0.001). The overall accuracy of the VOG was estimated at 80.53% with an error rate of 19.46%. There was no significant difference in VOG skew estimations compared with the gold standard except for very small skews. Conclusions VOG offers an objective and quantitative skew measurement and proved to be accurate in measuring vertical eye misalignment compared to the ACT with prisms. Precision was moderate, which mandates a sufficient number of tests per subject.

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Section: The Advantage Of Vog Skew Testingmentioning

confidence: 99%

Automated alternate cover test for ‘HINTS’ assessment: a validation study

Morrison

Kerkeni

Korda

et al. 2021

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…Experts, familiar with eye movement examinations, however, might not benefit as much as nonexperts from an automated system, unless the automated skew test is part of a comprehensive battery of other vestibular tests integrated into one and the same device like the one we evaluated here. There are other clinical signs associated with skew deviation in dizzy patients such as ocular counterroll detected by fundoscopy, 19 subjective visual vertical, 17 the maddox rods, 18,19 or by the Hess-Lancaster test and Parks-Bielschowsky test. 19 Such additional tests performed by experts could add more diagnostic certainty in patients with suspected skew deviation.…”

Section: The Advantage Of Vog Skew Testingmentioning

confidence: 99%

“…There are other clinical signs associated with skew deviation in dizzy patients such as ocular counterroll detected by fundoscopy, 19 subjective visual vertical, 17 the maddox rods, 18,19 or by the Hess-Lancaster test and Parks-Bielschowsky test. 19 Such additional tests performed by experts could add more diagnostic certainty in patients with suspected skew deviation.…”

Section: The Advantage Of Vog Skew Testingmentioning

confidence: 99%

Automated alternate cover test for ‘HINTS’ assessment: A validation study

Morrison¹,

Mantokoudis²,

Korda³

2021

Preprint

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ObjectiveThe alternate cover test (ACT) in patients with acute vestibular syndrome is part of the 'HINTS' battery test. Although quantitative, the ACT is highly dependent on the examiner's experience and could theoretically vary greatly between examiners. In this study, we sought to validate an automated video-oculography (VOG) system based on eye tracking and dedicated glasses. MethodsWe artificially induced a vertical strabismus to simulate a skew deviation on 10 healthy subjects, aged from 26 to 66, using different press-on Fresnel prisms on one eye while recording eye position with VOG of the contralateral eye. We then compared the system's performance to that of a blinded trained orthoptist using

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“…We report decrease in Firmicutes (F) and increase in Bacteriodetes (B) leading to consolidated decrease in F/B ratio in the gut communities of pAs-mice compared to control-mice which essentially mirrors the F/B ratio of the dams. The difference in the magnitude of the drop in F/B ratio between dams and offsprings could be attributable to the dams' vaginal microbiome and environmental factors that also influence the establishment of gut microbiome in neonates (Tudor et al 2017). The decrease in F/B ratio is a major biomarker of Inflammatory Bowel Disease (IBD) (Guo et al 2021) suggesting a possibility that pAs-mice may have physiological dysfunction in the gut.…”

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confidence: 99%

Prenatal arsenic exposure stymies gut butyrate production and enhances gut permeability in post natal life even in absence of arsenic deftly through miR122-Occludin pathway

Chakraborty

Gautam

Das

et al. 2022

Preprint

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This discourse attempts to capture a few important dimensions of gut physiology like microbial homeostasis, short chain fatty acid (SCFA) production, occludin expression and gut permeability in post-natal life of mice those received arsenic only during pre-natal life (pAs-mice). The pAs-mice showed a striking reduction in Firmicutes to Bacteroidetes (F/B) ratio coupled with decrease in tight junction protein, occludin resulting in increase in gut permeability, increased infiltration of inflammatory cells in the colon and decrease in common SCFAs in which butyrate reduction was quite prominent in fecal samples as compared to normal control. The above phenotypes of pAs-mice were mostly reversed by supplementing butyrate with food. The talismanic ability of butyrate in enhancing occludin expression, in particular, was dissected further. As miR122 causes degradation of Occludin mRNA, we transiently overexpressed miR122 by injecting appropriate plasmids and showed reversal of butyrate effects in pAs-mice. Thus, pre-natal arsenic exposure orchestrates variety of effects by decreasing in butyrate in pAs-mice leading to increased permeability due to reduced occludin expression. Our research adds a new dimension to our understanding that pre-natal arsenic exposure imprints in post-natal life while there was no further arsenic exposure.

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Skew Deviation: Case Report and Review of the Literature

Cited by 6 publications

References 33 publications

Automated alternate cover test for ‘HINTS’ assessment: a validation study

Automated alternate cover test for ‘HINTS’ assessment: a validation study

Automated alternate cover test for ‘HINTS’ assessment: A validation study

Prenatal arsenic exposure stymies gut butyrate production and enhances gut permeability in post natal life even in absence of arsenic deftly through miR122-Occludin pathway

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