Skin Adhesives with Controlled Adhesion by Polymer Chain Mobility

Gu, Zhen; Wan, Xizi; Lou, Zheng; Zhang, Feilong; Shi, Liqin; Li, Siheng; Dai, Bing; Shen, Guozhen; Wang, Shutao

doi:10.1021/acsami.8b18947

Cited by 55 publications

(57 citation statements)

References 35 publications

(64 reference statements)

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“…Although genotoxicity assays are still required, the results of this work show the relevance of refining our roadmap for interpreting data for a better understanding of the interactions between different GRMs and human barriers, with particular attention paid to metabolism and mitochondria even when an evident phenotype is not noticeable. These studies are also important because some GRMs have already been proposed for use in contact with skin, for example in textiles 29 or wearable electronics 30 , 31 . Special care must be taken to study the degradation and release of these materials during service life.…”

Section: Introductionmentioning

confidence: 99%

Sublethal exposure of small few-layer graphene promotes metabolic alterations in human skin cells

Frontiñán-Rubio

Gómez

González

et al. 2020

Sci Rep

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Small few-layer graphene (sFLG), a novel small-sized graphene-related material (GRM), can be considered as an intermediate degradation product of graphene. GRMs have a promising present and future in the field of biomedicine. However, safety issues must be carefully addressed to facilitate their implementation. In the work described here, the effect of sub-lethal doses of sFLG on the biology of human HaCaT keratinocytes was examined. A one-week treatment of HaCaTs with sub-lethal doses of sFLG resulted in metabolome remodeling, dampening of the mitochondrial function and a shift in the redox state to pro-oxidant conditions. sFLG raises reactive oxygen species and calcium from 24 h to one week after the treatment and this involves the activation of NADPH oxidase 1. Likewise, sFLG seems to induce a shift from oxidative phosphorylation to glycolysis and promotes the use of glutamine as an alternative source of energy. When sub-toxic sFLG exposure was sustained for 30 days, an increase in cell proliferation and mitochondrial damage were observed. Further research is required to unveil the safety of GRMs and degradation-derived products before their use in the workplace and in practical applications.

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Section: Introductionmentioning

confidence: 99%

Sublethal exposure of small few-layer graphene promotes metabolic alterations in human skin cells

Frontiñán-Rubio

Gómez

González

et al. 2020

Sci Rep

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“…However, the contradiction between the good mechanical and adhesion properties of PDMS restricts its practical application as a skin adhesive material. In contrast to our previous work 45 , we solved this contradiction by integrating lightly and highly crosslinked PDMS with an interfacial hydrosilylation reaction and first revealed its underwater adhesion properties. Our Janus adhesive tape with simultaneous strong wet/dry adhesion and high strength may provide an alternative candidate material to replace traditional homogeneous tapes.…”

Section: Resultsmentioning

confidence: 82%

“…In fact, if not pressed very hard, our Janus adhesive tape will leave little residue on the surface. Even if residue appears, in vitro cell culture 44 and skin experiments 45 have indicated the low cytotoxicity and good biocompatibility 46 of residual PDMS. The different surface topographies on silicon wafers could be attributed to the different polymer chain mobilities of these three tapes (Fig.…”

Section: Resultsmentioning

confidence: 99%

Asymmetric Janus adhesive tape prepared by interfacial hydrosilylation for wet/dry amphibious adhesion

Wan

Zhang

et al. 2019

NPG Asia Mater

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Janus films with asymmetric properties on opposite sides have been widely used to facilitate energy storage, ion transport, nanofiltration, and responsive bending. However, studies on Janus films rarely involve controlling surface adhesion, either dry or wet adhesion. Herein, we report Janus adhesive tape with an asymmetrically crosslinked polydimethylsiloxane (PDMS) network prepared through an interfacial hydrosilylation strategy, realizing wet/dry amphibious adhesion on various solid surfaces. The lightly crosslinked side of the Janus adhesive tape acts as an adhesive layer with high adhesion, and the highly crosslinked side functions as a supporting layer with high mechanical strength. This Janus adhesive tape with good adhesion and mechanical properties can be dyed different colors and can act as an underwater adhesive and a skin adhesive for wearable electronic devices. This study provides a promising design model for next-generation adhesive materials and related applications.

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“…In addition, our biofilms inherit the bendability from wood slice (Figure S5, Supporting Information), facilitating the on‐skin adherence. Also, the massive –OH groups (evidenced by the FTIR peak at 3346 cm −1 , Figure S2, Supporting Information) make our biofilms adhere easily to the “sweating” surface of the skin (the adhesion of skin adhesives depends on the free polymer chains on the adhesive surface). Altogether, covering our biofilms with a multifunctional electrical L‐rGO layer would enhance the compressive resistance and tensile resistance ⊥ , the impressive tensile resistance // and bendability make our biofilms competent for applications in On‐skinE.…”

Section: Resultsmentioning

confidence: 99%

Breathable Nanowood Biofilms as Guiding Layer for Green On‐Skin Electronics

Zhou

Wang

Huang

et al. 2019

Small

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thermoelectric [3,4] and moisture-inducedelectric [5] effects also has gained great attention (skin and on-skin electronics (On-skinE) themselves are energy storehouse). However, several challenges are to be faced, "thin-film" On-skinE I) cannot install "bulky" heatsinks [6] or sweat transport channels, but the output power of the thermoelectric generator and moistureinduced-electric generator depends on the temperature difference (∆T) across generator [4] and the ambient humidity (AH), [5] respectively; II) also lack a routing and accumulation of sweat for biosensing technologies, [7,8] and lack a targeted delivery of drugs for precise feedback transdermal therapy technologies; [9,10] and III) need insulate between the heatgenerating unit and heat-sensitive unit.In these regards, a "routing and accumulation" of heat and sweat can "concurrently" enhance the ∆T/AH-dependent output power, enable a reliable sweatbased biosensing, and prove the ability of targeted delivery of saline-soluble drugs for precise feedback transdermal therapy. Therefore, it is in great demand for developing strong-guiding films, which can help insulate between units and guide the heat and sweat to another in-plane direction.Besides, breathability [3] and stretchability [11] are essential for the on-skin use of electronics with long-term comfort. Several strategies have been proposed to realize the "stretchability" and the strategy placing rigid electronic units on the Thin-film electronics are urged to be directly laminated onto human skin for reliable, sensitive biosensing together with feedback transdermal therapy, their self-power supply using the thermoelectric and moisture-induced-electric effects also has gained great attention (skin and on-skin electronics (On-skinE) themselves are energy storehouses). However, "thin-film" On-skinE 1) cannot install "bulky" heatsinks or sweat transport channels, but the output power of thermoelectric generator and moisture-induced-electric generator relies on the temperature difference (∆T ) across generator and the ambient humidity (AH), respectively; 2) lack a routing and accumulation of sweat for biosensing, lack targeted delivery of drugs for precise transdermal therapy; and 3) need insulation between the heat-generating unit and heat-sensitive unit. Here, two breathable nanowood biofilms are demonstrated, which can help insulate between units and guide the heat and sweat to another in-plane direction. The transparent biofilms achieve record-high transport // /transport ⊥ (//: along cellulose nanofiber alignment direction, ⊥: perpendicular direction) of heat (925%) and sweat (338%), winning applications emphasizing on ∆T/AH-dependent output power and "reliable" biosensing. The porous biofilms are competent in applications where "sensitive" biosensing (transporting // sweat up to 11.25 mm s −1 at the 1st second), "insulating" between units, and "targeted" delivery of saline-soluble drugs are of uppermost priority.

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Skin Adhesives with Controlled Adhesion by Polymer Chain Mobility

Cited by 55 publications

References 35 publications

Sublethal exposure of small few-layer graphene promotes metabolic alterations in human skin cells

Sublethal exposure of small few-layer graphene promotes metabolic alterations in human skin cells

Asymmetric Janus adhesive tape prepared by interfacial hydrosilylation for wet/dry amphibious adhesion

Breathable Nanowood Biofilms as Guiding Layer for Green On‐Skin Electronics

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