Skin Aging Remedies in Traditional Persian Medicine

Shirbeigi, Laila; Iranzadasl, Maryam; Mansouri, Parvin; Hejazi, Somayeh; Aliasl, Jale

doi:10.17795/jssc3028

Cited by 7 publications

(7 citation statements)

References 42 publications

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“…Phytochemicals of TPM plants relevant to ARDs treatment. Following our literature review, a total of 215 plants were identified to be practiced TPM for treatment of the ARDs [29][30][31][32][33][34] (the entire list of all plants is represented in Supplementary Table S1 online). Among these, eight herbs that were found to be used in the treatment of at least three ARDs were selected for further inspection.…”

Section: Resultsmentioning

confidence: 99%

“…Building on our previous work 29 – 32 and literature review) 33 , 34 , herbal medicines in TPM for ARDs were identified. A number of significant Persian medical and pharmaceutical manuscripts, such as Liber Continents by Rhazes 36 , The Canon of Medicine by Avicenna 37 , and Tohfat ol Moemenin by Mohammad Tunakabuni 38 were used to retrieve geriatric remedies in these studies.…”

Section: Methodsmentioning

confidence: 99%

“…Identification of TPM plants relevant to ARDs therapies. In the first step of our study, the medicinal plants applied in the TPM-based treatment of ARDs, including cancer, cardiovascular diseases, neurodegeneration disorders, type 2 diabetes, and aging, were comprehensively reviewed [29][30][31][32][33][34] to identify the relevant herbal medicines (Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

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A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants

Mosaddeghi

Eslami

Farahmandnejad

et al. 2021

Sci Rep

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Aging is correlated with several complex diseases, including type 2 diabetes, neurodegeneration diseases, and cancer. Identifying the nature of this correlation and treatment of age-related diseases has been a major subject of both modern and traditional medicine. Traditional Persian Medicine (TPM) embodies many prescriptions for the treatment of ARDs. Given that autophagy plays a critical role in antiaging processes, the present study aimed to examine whether the documented effect of plants used in TPM might be relevant to the induction of autophagy? To this end, the TPM-based medicinal herbs used in the treatment of the ARDs were identified from modern and traditional references. The known phytochemicals of these plants were then examined against literature for evidence of having autophagy inducing effects. As a result, several plants were identified to have multiple active ingredients, which indeed regulate the autophagy or its upstream pathways. In addition, gene set enrichment analysis of the identified targets confirmed the collective contribution of the identified targets in autophagy regulating processes. Also, the protein–protein interaction (PPI) network of the targets was reconstructed. Network centrality analysis of the PPI network identified mTOR as the key network hub. Given the well-documented role of mTOR in inhibiting autophagy, our results hence support the hypothesis that the antiaging mechanism of TPM-based medicines might involve autophagy induction. Chemoinformatics study of the phytochemicals using docking and molecular dynamics simulation identified, among other compounds, the cyclo-trijuglone of Juglans regia L. as a potential ATP-competitive inhibitor of mTOR. Our results hence, provide a basis for the study of TPM-based prescriptions using modern tools in the quest for developing synergistic therapies for ARDs.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants

Mosaddeghi

Eslami

Farahmandnejad

et al. 2021

Sci Rep

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“…Certain aspects of temperament can be changed, and this change leads to illness [26]. Sustaining a temperament in which a person feels well is associated with the appropriate lifestyle of a temperament [27]. The appropriate amount of water intake per person depends on each individual’s temperament in addition to environmental factors [10, 11].…”

Section: Resultsmentioning

confidence: 99%

Water Intake from the Points of View of Rhazes and Avicenna

et al. 2019

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Owing to the effect of acute and chronic hypohydration on health and the lethal effects of hyperhydration, an appropriate amount of water intake is important for each individual. Traditional Iranian medicine (TIM) is a holistic system one of whose important parts deals with lifestyles and how to maintain health, including the amount of water intake for every person and the appropriate principles of drinking water. In this study, Avicenna’s Canon of Medicine, Rhazes’ Benefits of Food and Its Harmfulness, and conventional medical articles were reviewed to evaluate the amount of water intake for each person and the principles of drinking water. TIM has expressed an individualized difference in the amount of water intake in the form of temperament and the relationship between the appropriate time of drinking water with other daily activities. In this view, drinking water at the inappropriate time causes liver and gastrointestinal diseases; it can create the foundation for conducting new studies in the field of appropriate water intake and lifestyle changes to reduce malnutrition complications.

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“…Digestive system could be strengthened by consuming different kinds of jams, such as Ginger jam. Complete defecation is one of the treatment rules in ITM, as chronic constipation causes specific toxins accumulation in the intestinal loop and facilitates its spread all over the body (16). Medicinal plants are recommended in the second step.…”

Section: Acne Management Stepsmentioning

confidence: 99%

A Review of Acne Etiology and Treatment in Iranian Traditional Medicine

et al. 2016

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Context: Iranian traditional medicine (ITM) is based on humoral theory. Temperament or Mizaj is the result of a combination of four cardinal humors. They are blood, phlegm, yellow bile (Safra) and black bile (melancholy). Like any other disease, acne is the result of humoral imbalance. Acne is a highly prevalent dermatologic problem, which has both physical and psychological effects. The aim of this study was to introduce the etiology of acne and its remedies from the perspective of ITM. Evidence Acquisition: Etiology and treatment of acne were studied and analyzed from selected medical textbooks of ITM. Some of the effective plants in these books were assessed in a table, and their anti-acne activities were compared with conventional medicine's database. Results: From the perspective of ITM, considering six essential schemes for health, diet and herbal remedies as well as manipulation are recommended for acne treatment. Although the introduced plants have antibacterial, anti-inflammatory and antioxidant effects but some of them have special proven effects on acne formation process. There is also a strong relationship between digestive system and skin. Conclusions: This paper was rendered to show ancient Persian scholar's point of view about acne and its treatment, and it was shown that Iranian traditional medicine has practical recommendations for acne treatment.Keywords: Acne, Iranian Traditional Medicine, Diet, Herbal Remedies, Digestivesystem ContextAcne is a common dermatological disease highly prevalent in the age group of 12 to 25 years. It affects patients both physically and psychologically, resulting impaired psychosocial development, reduced self-esteem and emotional distress due to perceived disfigurement (1). Acne vulgaris is diagnosed by variable clinical manifestations such as white or black comedones, papules and pustules. Acne scarring is the sequel of severe cases (2). The etiology of this problem involves high sebum secretion, bacterial infection, hyperkeratinisation as well as hormonal change in the body (3). Reducing scars and erythematous lesions is the aim of treatment. Hence combination of systemic and topical agents is recommended in severe cases (4, 5). Oral Isotretinoin is the main choice of treatment in severe cases yet side effects like dyslipidemia and dry mucous membranes are usually considered (6, 7). In Iranian traditional medicine (ITM), skin and nervous system have the same origin. Skin can represent internal organs function and its duty is to protect human body from external stressors (8). Body temperature regulation is another crucial task performed by the skin in human body and small pores in the skin play important roles regarding this ability. In addition to this, skin has an ability to secrete surplus substances in different forms of discharges, and acne formation could be the result of this phenomena. According to the theory of humors in ITM, dystemperament or "Suemizaj" may occur when there is an imbalance in humoral quantity or quality (9). This humoral imbalan...

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Skin Aging Remedies in Traditional Persian Medicine

Cited by 7 publications

References 42 publications

A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants

A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants

Water Intake from the Points of View of Rhazes and Avicenna

A Review of Acne Etiology and Treatment in Iranian Traditional Medicine

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