Skin and Muscle Blood Flow During Regional Perfusion with Hyperthermal Perfusate

Englund, N. E.; Hallböök, T; Ling, L; Vang, J

doi:10.3109/14017437409129068

Cited by 8 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rise ~n tumor temperature up to 41°C leads to a significant increase n tumor blood flow (TBF). This effect has also been demonstrated by Engtund et al (20) and Sutton (46) for both the tumor region and host organ. AS tO the cause of this increased flow.…”

Section: Discussionsupporting

confidence: 78%

See 1 more Smart Citation

Effects of hyperthermia on normal and tumor microenvironment.

Bicher¹,

Hetzel²,

Sandhu³

et al. 1980

Radiology

180

View full text Add to dashboard Cite

The effects of hyperthermia on pH, local blood flow (LBF) and tissue oxygen tension (TpO2) in several normal and tumor tissues were studied. It was found that TpO2, local blood flow and pH are inhomogeneous in tumor tissue. TpO2 is very low in certain areas which also seem deprived of blood flow and are at very low pH. Hyperthermia has a dual effect: at temperatures below 41 degrees C, it increases blood flow and TpO2 while above 41 degrees C, it causes a collapse in blood flow, lower TpO2 and a shift of the tissue pH towards acidosis from the already low pH values found in tumors.

show abstract

Section: Discussionsupporting

confidence: 78%

“…Englund et al (20) and Sutton (46) have demonstrated that during hyperthermla local blood flow increases in the tumor region and also in the organ hosting the tumor. While measuring the local oxygen levels as well as the local blood flow to the tumor, recent experiments demonstrate tl~!…”

mentioning

confidence: 99%

Effects of hyperthermia on normal and tumor microenvironment.

Bicher¹,

Hetzel²,

Sandhu³

et al. 1980

Radiology

180

View full text Add to dashboard Cite

show abstract

Improved tissue perfusion during pressure regulated hyperthermic regional isolated perfusion. A clinical study

Fontijne

Mook

Koops

et al. 1985

Cancer

View full text Add to dashboard Cite

In previous studies on isolated hindlimb perfusions in dogs, the authors proved that the extracorporeal circuit should be regulated at a delta pressure (systemic mean arterial pressure minus hindlimb mean arterial pressure) of not more than 15 mmHg, to achieve adequate tissue perfusion. To confirm this in patients the authors performed clinical perfusions, divided into three groups. In group I and II the extracorporeal circuit was regulated at a delta pressure of 15 mmHg and 50 mmHg, respectively. In group III perfusions were performed using the common technique of a predetermined fixed flow. Tissue oxygenation, determined by means of a transcutaneous pO2 electrode, was adequate in group I and was severely impaired in group II and III. Although in group I high perfusion flows were needed, leakage was less than 10%. To achieve adequate tissue perfusion during clinical regional perfusions, the extracorporeal circuit must be regulated at a delta pressure of 15 mmHg.

show abstract

Hyperthermia-induced vascular injury in normal and neoplastic tissue

Badylak

Babbs

Skojac

et al. 1985

Cancer

View full text Add to dashboard Cite

The sequential morphologic alterations in normal skeletal muscle in rats, Walker 256 tumors in rats, and transmissible venereal tumors (TVT) in dogs following microwave-induced hyperthermia (43 degrees C and 45 degrees C for 20 minutes), were studied by histologic and ultrastructural examination. Normal muscle and Walker 256 tumors showed edema, congestion, and hemorrhage at 5 minutes post-heating (PH), followed by suppuration, macrophage infiltration, and thrombosis at 6 and 48 hours PH, and finally by regeneration and repair by 7 days PH. Vascular endothelial damage and parenchymal degeneration were present 5 minutes PH. Progressive injury occurred for at least 48 hours PH. Two hyperthermia treatments separated by a 30- or 60-min cooling interval, were applied to Walker 256 tumors in a subsequent study. Increased selective heating of tumor tissue versus surrounding normal tissue, and increased intratumoral steady state temperatures were found during the second hyperthermia treatment. Canine TVTs were resistant to hyperthermia damage. These results suggest that vascular damage contributes to the immediate and latent cytotoxic effects of hyperthermia in normal tissue and some types of neoplastic tissue, and that selective heating of neoplastic tissue occurs in tumor tissue with disrupted microvasculature.

show abstract

Skin and Muscle Blood Flow During Regional Perfusion with Hyperthermal Perfusate

Cited by 8 publications

References 4 publications

Effects of hyperthermia on normal and tumor microenvironment.

Effects of hyperthermia on normal and tumor microenvironment.

Improved tissue perfusion during pressure regulated hyperthermic regional isolated perfusion. A clinical study

Hyperthermia-induced vascular injury in normal and neoplastic tissue

Contact Info

Product

Resources

About