Skin autofluorescence, renal insufficiency and retinopathy in patients with type 2 diabetes

Bentata, Rabia; Cougnard‐Grégoire, Audrey; Delyfer, M.-N.; Delcourt, Cécile; Blanco, Laurence; Pupier, E.; Rougier, M.–B.; Rajaobelina, Kalina; Hugo, M; Korobelnik, J.-F.; Rigalleau, Vincent

doi:10.1016/j.jdiacomp.2016.10.028

Cited by 18 publications

(14 citation statements)

References 31 publications

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“…We found a significant association among high AGE levels and male gender, diabetes, and no smoking. Diabetes is a well-known factor that accelerates AGE levels [ 38 , 39 , 40 ]. There is no consensus about the gender difference in the AGE levels, which should be studied further.…”

Section: Discussionmentioning

confidence: 99%

“…For the PG, EG, and control groups, eyes with ocular diseases other than glaucoma and cataract and decimal BCVA worse than 0.01 were excluded. Since the association between diabetes and AGEs has been well documented [ 38 , 39 , 40 ], patients with severe diabetes that required insulin and was associated with the presence of diabetic retinopathy were excluded.…”

Section: Methodsmentioning

confidence: 99%

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Advanced Glycation End Product Accumulation in Subjects with Open-Angle Glaucoma with and without Exfoliation

et al. 2020

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Advanced glycation end products (AGEs), which are the products of a non-enzymatic reaction between reducing sugars and other macromolecules, are critical in aging, as well as metabolic and degenerative diseases. To assess the involvement of AGEs in glaucoma, skin autofluorescence (sAF) level, which is a measurement of AGEs’ accumulation, was compared among Japanese patients with glaucoma (316 with primary open-angle glaucoma (PG) and 127 exfoliation syndrome and glaucoma (EG)) and controls (133 nonglaucomatous controls) (mean age 71.6 ± 12.8 years, 254 men and 322 women). The sAF values were estimated from the middle fingertip using a 365 nm light-emitting diode for excitation and detection at 440 nm emission light. The estimated AGE values (arbitrary unit) were 0.56 ± 0.15, 0.56 ± 0.11, and 0.61 ± 0.11 in the control, PG, and EG groups, respectively (p < 0.0001, analysis of variance); and were significantly higher in the EG group than the control (p = 0.0007) and PG (p < 0.0001) groups. After adjustment for various demographic parameters by multivariate analyses, male sex (standard β = 0.23), EG (0.19), and diabetes (0.09) were associated with higher AGE levels; PG (−0.18) and smoking (−0.19) were associated with lower AGE levels. Age, visual acuity, intraocular pressure, glaucoma medications, lens status, and systemic hypertension were not associated with AGEs. The high AGE level in EG suggested that specific oxidation and glycation mechanisms underlie the glaucoma pathogenesis associated with pseudoexfoliation syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Advanced Glycation End Product Accumulation in Subjects with Open-Angle Glaucoma with and without Exfoliation

et al. 2020

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“…The role of AGEs in the genesis and rapid progression of both macro-and microvascular chronic T2D complications has been suggested previously [7].…”

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confidence: 87%

Subcutaneous advanced glycation end-products and lung function according to glucose abnormalities: The ILERVAS Project

Sánchez

Lecube²,

Betriu

et al. 2019

Diabetes & Metabolism

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“…In recent years, skin AGEs have been utilised more frequently for diagnostic purposes as they offer a noninvasive, and inexpensive diagnostic tool with a high degree of reproducibility. Increased skin AGEs has been thoroughly studied in the context of microvascular complications of diabetes mellitus (Table 1) [5,[22][23][24][25][26][27][28][29][30][31][32][33].…”

Section: Skin Ages and Diabetic Microvascular Complicationsmentioning

confidence: 99%

“…AGEs: advanced glycation end products; NADPH: Nicotinamide adenine dinucleotide phosphate; RAGE: receptor of advanced glycation end products; ROS: reactive oxygen species group reported that increased AGEs are linked with vascular endothelial growth factor (VEGF) overproduction (another major pathogenetic mechanism) [32]. Nevertheless, previous evidence is rather controversial, with a number of studies reporting lack of association with skin AGEs [23,30,34], others reporting a clear independent correlation with retinopathy [24,25,28] and disease severity [29], whereas, interestingly, macular oedema seems to develop independently of any increase in the levels of skin AGEs (Table 1) [26,29].…”

Section: Skin Ages and Diabetic Microvascular Complicationsmentioning

confidence: 99%

Skin AGEs and diabetic neuropathy

2021

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Advanced glycation end-products (AGEs) are heterogeneous molecules produced by the non-enzymatic glycation of proteins, lipids, or nucleic acids during hyperglycaemia. Accumulation of AGEs in the peripheral nerves has recently been proposed as an additional risk factor for the development of diabetic neuropathy (DN). The gold standard for measurement of tissue-bound AGEs is tissue biopsy. However, their assessment with the newer, fast and simple method of skin autofluorescence (sAF) has recently gained special interest by virtue of its non-invasive, highly reproducible nature and its acceptable correlation with the reference method of skin biopsy. Accumulation of tissue AGEs evaluated by sAF has been shown to independently correlate with DN. Importantly, increasing evidence underscores their potential value as early biomarkers of the latter. Further important associations include diabetic nephropathy, diabetic retinopathy and cardiovascular autonomic neuropathy. However, the value of the implementation of screening with skin AGEs for DN remains unclear. The aim of the present review is to critically summarise current evidence on the association between skin AGEs and diabetic microvascular complications, with a particular emphasis on diabetic neuropathy, and to note the most important limitations of existing knowledge. Longer follow-up studies are also highly anticipated to clarify its role and provide data on patient selection and cost-effectiveness.

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Skin autofluorescence, renal insufficiency and retinopathy in patients with type 2 diabetes

Cited by 18 publications

References 31 publications

Advanced Glycation End Product Accumulation in Subjects with Open-Angle Glaucoma with and without Exfoliation

Advanced Glycation End Product Accumulation in Subjects with Open-Angle Glaucoma with and without Exfoliation

Subcutaneous advanced glycation end-products and lung function according to glucose abnormalities: The ILERVAS Project

Skin AGEs and diabetic neuropathy

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