Background: Collapsin response mediator protein 5 (CRMP5) influences neuronal differentiation and dendrite outgrowth during brain development. Results: CRMP5 is partially located in mitochondrial membranes, inducing mitophagy and reducing mitochondrial content of developing dendrites. Conclusion: Control of mitochondrion numbers by CRMP5 inhibits dendrite growth when the axon is growing. Significance: Learning how dendrite growth is regulated by CRMP5 is important for understanding the establishment of neuronal polarization.

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