Skin biology

Abstract

The development of topical drug delivery systems has recently gained significant interest due to the ease of administration and lesser risks of systemic toxicity. The development of these new technologies utilizes the properties of the structure and function of the skin. The stratum corneum plays the largest role in affecting drug permeation, as the corneocytes and lipid matrix in this layer effectively prevent the diffusion of large molecules. In this review, we introduce the structure and function of the skin as it relates to topical drug delivery.

Online web-based sun-protective behaviors

“…However it should be stressed that dermatology, as well as the other medical branches and specialties, has faced many progresses in recent years, thanks to the technological advancements (the so-called “teledermatology”)2 and the achievements in the field of molecular and systems biology 3…”

Handling of thermal paper: Implications for dermal exposure to bisphenol A and its alternatives

“…For many years, it was assumed that the skin was impermeable to “any substance”, but since World War II, when dermal treatments for a number of conditions including insect repellents and prophylactics for venereal diseases were developed, it has been understood that the skin can act as a “reservoir” for both drugs and non-pharmaceutical chemicals [44]. Mathematical modeling using the physiochemical properties of BPA suggest that it will be readily absorbed by intact human skin [45].…”

Basistherapeutika

“…Die Hautbarriere wird im Wesentlichen von der Hornschicht, dem Stratum corneum, gebildet [10]. Es besteht aus Korneozyten, d. h. den ausdifferenzierten, verhornten Keratinozyten, die 0,5 μm dick und ca.…”