Skin Cancer Incidence and Mortality in Spain: A Systematic Review and Meta-Analysis

Tejera‐Vaquerizo, Antonio; Descalzo, Miguel Ángel; Otero-Rivas, M.M.; Posada-García, C; Rodríguez-Pazos, L.; Pastushenko, Ievgenia; Marcos‐Gragera, Rafael; García‐Doval, I.

doi:10.1016/j.adengl.2016.02.015

Cited by 56 publications

(53 citation statements)

References 30 publications

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“…We also observed regional variations in melanoma mortality trends, which could be related to differences in incidence rates. Some cancer registries from the Northern regions of Spain have registered higher incidence rates than Central and Southern regions . The differences observed in sun irradiance among different regions in Spain could also contribute to the different trends observed across the country, as well as to a different distribution of skin phototypes.…”

Section: Discussionmentioning

confidence: 99%

Trends in mortality from cutaneous malignant melanoma in Spain (1982–2016): sex‐specific age‐cohort‐period effects

Gutiérrez‐González

López‐Abente

Aragonés

et al. 2019

Acad Dermatol Venereol

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Background Mortality from malignant cutaneous melanoma increased alarmingly during the second half of the 20th century in Spain and other European countries. Objective The aim was to analyse sex‐ and age‐specific trends in melanoma mortality in Spain in the period 1982–2016. Methods European age‐standardized melanoma mortality rates during the period 1982–2016 were calculated from mortality figures provided by the National Statistics Institute. Joinpoint regressions were used to identify significant points of change in trends and to compute average annual per cent change (AAPC). Age‐cohort‐period models were fitted to explore the effect of these variables on mortality. Results During the period 1982–2016, age‐standardized melanoma mortality rates increased in Spain from 0.90 to 1.80 deaths per 100 000 people in men and from 0.64 to 1.11 per 100 000 in women, rising noticeably from 1982 to 1995 in both sexes and in all age groups. From the mid‐90s different trends were observed depending on sex and age: there was a decrease in mortality in the population younger than 45 years (AAPC ‐2 in both sexes) and aged 45–64 years (AAPC ‐1 among men and ‐0.2 among women), but in the group over 64 years rates continued to increase (AAPC 1.7 and 0.2, respectively, for men and women). The mortality sex ratio decreased in the younger population but increased in older individuals. A cohort effect was observed with lower mortality in the cohorts born after 1943 in men and 1956 in women. There was also a period effect with decreased mortality rates at the beginning of the 1990s. Conclusions Melanoma mortality rates in Spain increased during the last decades of the 20th century; however, later they stabilized in women and began to decrease in younger cohorts and middle‐aged men. Promotion of primary and secondary prevention measures should continue, with particular emphasis on males over 65 years.

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Section: Discussionmentioning

confidence: 99%

Trends in mortality from cutaneous malignant melanoma in Spain (1982–2016): sex‐specific age‐cohort‐period effects

Gutiérrez‐González

López‐Abente

Aragonés

et al. 2019

Acad Dermatol Venereol

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“…Tejera‐Vaquerizo et al recently published more detailed data regarding NMSC epidemiology among the Spanish general population, documenting an incidence of 151.21/100 000 (113.05/100 000 of BCC and 38.16/100 000 of SCC) between the years 1980 and 2015.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous carcinogenic risk evaluation in 375 patients treated with narrowband‐UVB phototherapy

Raone

Patrizi

Gurioli

et al. 2018

Photoderm Photoimm Photomed

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“…Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer in the world and its incidence is rising. 1 Although it generally has a good prognosis, approximately 5% of patients develop metastases, typically to the lymph nodes. 2 Diverse clinical and pathological risk factors determining a worse prognosis have been identified in cSCC, and include tumor size and thickness, degree of differentiation, perineural invasion, invasion past subcutaneous tissue and a high-risk location.…”

Section: Introductionmentioning

confidence: 99%

Systematic review of the prevalence of nodal metastases and the prognostic utility of sentinel lymph node biopsy in cutaneous squamous cell carcinoma

Tejera‐Vaquerizo¹,

García‐Doval

Llombart

et al. 2018

The Journal of Dermatology

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Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and its incidence is rising. The prognosis is mostly good but patients with high-risk cSCC have a greater risk of recurrence and death. The aim of the present study was to conduct a systematic review analyzing the prevalence, predictors and prognostic utility of sentinel lymph node (SLN) involvement in cSCC. We performed a published work search in Ovid MEDLINE and reviewed the reference lists of selected studies. Based on the 23 studies included in the systematic review, the proportion of patients with cSCC and positive SLN biopsy findings was 8% (95% confidence interval, 5.1-10.8%; I = 44.51%). We found no studies reporting on predictors of SLN involvement in cSCC or on the prognostic utility of this finding following adjustment for confounders. The rate of positive SLN in cSCC is less than previously reported. Criteria for recommending SLN biopsy as a staging tool for cSCC vary considerably from study to study, and none of the studies were large enough to reliably identify predictors of SLN positivity. No randomized controlled trials have yet analyzed whether SLN biopsy may improve the prognosis of cSCC. More studies are required on the prognostic value of SLN positivity and the associated risk factors in cSCC.

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Skin Cancer Incidence and Mortality in Spain: A Systematic Review and Meta-Analysis

Cited by 56 publications

References 30 publications

Trends in mortality from cutaneous malignant melanoma in Spain (1982–2016): sex‐specific age‐cohort‐period effects

Trends in mortality from cutaneous malignant melanoma in Spain (1982–2016): sex‐specific age‐cohort‐period effects

Cutaneous carcinogenic risk evaluation in 375 patients treated with narrowband‐UVB phototherapy

Systematic review of the prevalence of nodal metastases and the prognostic utility of sentinel lymph node biopsy in cutaneous squamous cell carcinoma

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