Skin Cancers Following Pediatric Organ Transplantation

Abstract

BACKGROUND. Organ transplant recipients taking immunosuppressants are at increased risk of skin cancer. Although several studies have been devoted to adult transplant patients, few data are available on the long-term skin malignancies following pediatric organ transplantation. OBJECTIVE. The objective of this study was to present the current state of knowledge on skin malignancies in patients who received their graft during childhood. METHODS. This study reviews data from the literature and includes our personal experience. RESULTS. Skin cancer is the most frequent malignancy following pediatric renal transplantation and the second most common r

Epidemiology of de novo malignancies after solid-organ transplantation: Immunosuppression, infection and other risk factors

“…The mean age at diagnosis of post-transplant KS is around 40 years, so at least 20 years younger than the mean age at diagnosis of classic KS cases [72]. It is should be noted that very few cases are diagnosed in paediatric transplanted patients [73].…”

Adverse Effects of Immunosuppression in Pediatric Solid Organ Transplantation

“…[25] Melanoma also occurs more frequently in children (12% of skin cancers) than in adults (5%). [26] On the other hand, children have a lower risk for developing non-melanoma skin cancers than adults (RR = 0.15). [25] The types of malignancies that affect pediatric solid organ transplant recipients can vary with the type of organ transplant.…”

“…In contrast, skin cancers are the most common in kidney transplant recipients, followed by PTLD. [26] The types of malignancies also vary with the time after transplant. While the range of time to develop cancer is wide for all types, early malignancies tend to be virus-related, such as PTLD (related to EBV) and Kaposi's sarcoma (caused by human herpesvirus 8), and solid tumors tend to occur later following transplantation, [26] often in early adulthood.…”

“…[25] However, tacrolimus and ciclosporin are both linked to a higher incidence of lymphomas and Kaposi's sarcoma. [26,27] The time after transplantation has been shown to increase the incidence of malignancies following intestinal transplants. [28] Other risk factors for malignancies reflect the same risk factors for the general population.…”

Basal cell carcinoma in childhood: Case report and literature review

“…Childhood onset of BCC has previously been associated with albinism, 21,27 Bazex syndrome, 21,28 BCC nevus syndrome, 25,26,[29][30][31][32][33]53 nevus sebaceous, 2,25,26,[34][35][36][37][38][39][40] solid organ transplants, 47,48 xeroderma pigmentosum, 25,29,32,[49][50][51][52] and radiotherapy-treated cancers, such as astrocytoma, 44 ependymoma, 41 hemangioma, 26 Hodgkin lymphoma, 38,46 leukemia, 38,[42][43][44][45][46] medulloblastoma, 22,29,33,46 neuroblastoma, 38 optic nerve glioma, 41 and unspecified malignant tumor. 32 Children are defined to be 18 y...…”