Skin collagen changes related to age and hormone replacement therapy

Castelo-Branco, Camil; Durán, Magdalena; González-Merlo, J

doi:10.1016/0378-5122(92)90245-y

Cited by 175 publications

(59 citation statements)

References 10 publications

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“…As all subjects in the present study were women, this finding might be due to hormonal changes related to menopause and hormonal replacement therapy. In previous studies, menopause has been related to decrease in skin collagen, glycosaminoglycan and water content [33][34][35]. These changes lead to decrease in skin elasticity and strength [35].…”

Section: Discussionmentioning

confidence: 94%

Accuracy and reliability of a hand‐held in vivo skin indentation device to assess skin elasticity

Virén

Iivarinen

Sarin

et al. 2018

Intern J of Cosmetic Sci

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Section: Discussionmentioning

confidence: 94%

Accuracy and reliability of a hand‐held in vivo skin indentation device to assess skin elasticity

Virén

Iivarinen

Sarin

et al. 2018

Intern J of Cosmetic Sci

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“…While some studies demonstrated that ET significantly increased skin and dermal thickness in postmenopausal women [26][27][28] (as measured on thigh and abdomen), a study of 3875 women did not demonstrate any impact of ET on postmenopausal-associatedskinatrophy 19 (unspecifiedsite). Similarly, some studies demonstrated greater skin collagen content after ET 15,16,24,[27][28][29] (as measured on thigh, lower abdomen, upper inner arm, and unspecified site), while others did not show any beneficial effects of ET on collagen synthesis 30,31 (upper arm and unspecified site). A few studies have used topical estrogens on human skin.…”

mentioning

confidence: 99%

“…Diminution of circulating estrogens that accompanies menopause is associated with increased skin dryness 11 and slackness, 12 and decreased skin elasticity, 13 dermal thickness of thigh skin, 14 and skin collagen content as measured in thigh, 15 abdomen, 16 and pubis. 17 Conversely, various studies have shown that estrogen therapy (ET) users have better skin hydration [18][19][20][21] and elasticity, [20][21][22][23] higher density of collagen fibers, 24 fewer fine wrinkles, 19,21 and thicker skin 20,25 than nonusers.…”

mentioning

confidence: 99%

Induction of Collagen by Estradiol

Rittié¹,

Kang²,

Voorhees³

et al. 2008

Arch Dermatol

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To evaluate the effectiveness of topical estradiol in stimulating collagen I and III production in naturally aged and photoaged human skin of postmenopausal women and age-matched men.Design: Vehicle-controlled treatment followed by biochemical and immunohistochemical analyses of skin biopsy specimens.Setting: Academic referral center.Participants: Seventy healthy volunteers (40 postmenopausal women with a mean age of 75 years, and 30 men with a mean age of 75 years) with photodamaged skin.Interventions: Topical application of estradiol, 0.01%, 0.1%, 1%, or 2.5% or vehicle on aged or photoaged skin, with biopsy specimens taken after last treatment.Main Outcome Measures: De novo synthesis of collagen by quantitative polymerase chain reaction, immunohistochemistry, and enzyme-linked immunosorbent assay.Results: Topical estradiol increased procollagen I and III messenger RNA and collagen I protein levels in sun-protected aged hip skin in postmenopausal women and, to a lesser extent, in age-matched men. Surprisingly, no significant changes in production were observed in women or men after 2-week estradiol treatment of photoaged forearm or face skin, despite similar expression of estrogen receptors (ER-␣, ER-␤, and GPR30) in aged and photoaged skin. Estradiol treatment induced the estrogenresponsive gene GREB1, indicating that penetration of topical estradiol and genomic response to estrogen were similar in the 3 anatomic sites.Conclusions: Two-week topical estradiol treatment stimulates collagen production in sun-protected hip skin, but not in photoaged forearm or face skin, in postmenopausal women and aged-matched men. These findings suggest that menopause-associated estrogen decline is involved in reduced collagen production in sun-protected skin. Interestingly, alterations induced by long-term sun exposure hinder the ability of topical 2-week estradiol to stimulate collagen production in aged skin.

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“…The results of these studies are compatible with our present data. Additional evidence implicating hypoestrogenism in skin collagen loss in menopause is provided by improvement with hormone replacement therapy [4,5,17,24]. Bone mass loss related to menopause also is reversed by such therapy [25,26].…”

Section: Discussionmentioning

confidence: 99%

“…Skin collagen content and bone mineral density (BMD) share comparable regressive changes during the aging process. Several studies have reported that skin collagen content decreases with age and loss of estrogen [3][4][5][6], while loss of skin collagen is associated with number of years following menopause [3,[5][6][7]. Menopause is also the major risk factor for bone loss [8][9][10], and bone density shows an age-and estrogen-related decline [3,6,11].…”

mentioning

confidence: 99%

Effects of Aging and Postmenopausal Hypoestrogenism on Skin Elasticity and Bone Mineral Density in Japanese Women

Sumino

Ichikawa²,

Abe

et al. 2004

Endocr J

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Abstract. Skin collagen content and bone mass decrease with aging. Loss of collagen from the skin might decrease its elasticity. We investigated associations between skin elasticity, bone mineral density (BMD), age, and menopausal hypoestrogenism. Thirty-eight healthy Japanese postmenopausal women were studied (mean age, 55.7 ± 5.9 yr; range, 48 to 71). Skin elasticity was measured using a suction device applied to the dorsal right forearm. BMD values of L2 to 4 vertebral bodies were measured by dual-energy X-ray absorptiometry. Age showed significant negative correlations with both skin elasticity and BMD (r = -0.57, p<0.001 and r = -0.40, p<0.05, respectively). Years since menopause also showed significant negative correlations with both skin elasticity and BMD (r = -0.51, p<0.01 and r = -0.41, p<0.05, respectively). We also found a positive correlation between skin elasticity and BMD in these postmenopausal women (r = 0.44, p<0.01). In conclusion, we demonstrated declining skin elasticity and bone mass in postmenopausal women to possibly be age-and estrogen-related. Additionally, decreased skin elasticity might serve as a predictor of bone loss in postmenopausal women. COLLAGEN constitutes approximately one-third of total body mass [1]. Skin and bone share similar loose connective tissue, respectively located in the dermis and the organic bone matrix. Both bone matrix and dermis are composed of more than 70% type I collagen [2]. Skin collagen content and bone mineral density (BMD) share comparable regressive changes during the aging process. Several studies have reported that skin collagen content decreases with age and loss of estrogen [3][4][5][6], while loss of skin collagen is associated with number of years following menopause [3,[5][6][7]. Menopause is also the major risk factor for bone loss [8][9][10], and bone density shows an age-and estrogen-related decline [3,6,11]. Hypoestrogenism might contribute in parallel to loss of skin collagen and bone mass in women, while collagen loss from skin reduces its thickness and elasticity [6,12]. However, no simultaneously obtained data have been presented to correlate skin elasticity and bone mineral content with aging and menopausal hypoestrogenism.A new suction device was recently developed to simply, rapidly, and noninvasively quantify skin elasticity in vivo. Clinical applications of these measurements have been reported by several authors [12][13][14][15][16][17]. In the present study, we simultaneously measured skin elasticity in the forearm and lumbar spine BMD (L2 to 4) in Japanese postmenopausal women to investigate associations of skin elasticity and bone mineral content with one another as well as with age and duration of menopausal hypoestrogenism.

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Skin collagen changes related to age and hormone replacement therapy

Cited by 175 publications

References 10 publications

Accuracy and reliability of a hand‐held in vivo skin indentation device to assess skin elasticity

Accuracy and reliability of a hand‐held in vivo skin indentation device to assess skin elasticity

Induction of Collagen by Estradiol

Effects of Aging and Postmenopausal Hypoestrogenism on Skin Elasticity and Bone Mineral Density in Japanese Women

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