Skin Damage and Tumor Formation from Grid and Sieve Patterns of Electron and Beta Radiation in the Rat

Albert, Roy E.; Burns, Fredric J.; Heimbach, Richard D.

doi:10.2307/3572117

Cited by 39 publications

(16 citation statements)

References 6 publications

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“…The rat skin results indicate that carcinogenic alterations are subject to repair processes similar to those observed for cell lethality (13,14,15,16). A lower cancer yield was observed when electron radiation doses were split into 2 doses separated in time (Figure 4).…”

Section: Cancer Incidence In Irradiated Rat Skinmentioning

confidence: 78%

Progression and Multiple Events in Radiation Carcinogenesis of Rat Skin

Burns

Hosselet

Jin

et al. 1991

JRR

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Section: Cancer Incidence In Irradiated Rat Skinmentioning

confidence: 78%

Progression and Multiple Events in Radiation Carcinogenesis of Rat Skin

Burns

Hosselet

Jin

et al. 1991

JRR

Self Cite

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“…In an initial experiment which involved the irradiation of rat skin with electrons, the tumor incidence per unit area was reduced when the radiation dose was given in a sieve pattern (3).…”

Section: Introductionmentioning

confidence: 99%

Tumor Incidence in Rat Skin Following Proton Irradiation in a Sieve Pattern.

Burns¹,

Albert²,

Bennett³

et al. 1972

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The dorsal skin of 183 male, albino rats was irradiated with 8.0 Mev protons at various doses in a uniform pattern and at two doses in sieve patterns with pore diameters of 5.0 mm, 2.0 mm and 0.5 mm. The depth-dose curve of the proton beam was modified so that it was approximately linear with a maximum penetration of about 0"8 mm. Skin lesions were noted every 4 weeks for 80 weeks and at the end of the experiment were examined histologically.The results indicated that the sieve pattern did not significantly affect the tumor incidence per unit irradiated area or the incidence of damaged hair follicles at any pore size. This contrasts ---' to the results of earlier experiments with electrons where a sieve pattern produced a significant protective effect at a pore diameter of 2.5 mm. Possible explanations for this discrepancy are discussed.'. \ 4t'7.

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“…The hypothesis of the 'hot particle effect' appears to be put to rest. With electrons and soft X rays the use of a sieve pattern of exposure, which is used in radiotherapy to protect the skin, reduced the tumorigenic effect (Albert and Burns, 1967) but with protons it did not (Burns et al, 1972). (Baker and Habowsky, 1983) and delayed-type hypersensitivity as a function of X-ray exposure 10 days post irradiation.…”

Section: Dose-response Relationshipsmentioning

confidence: 99%

Radiation Protection Guidelines for the Skin

Fry

1990

International Journal of Radiation Biology

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Skin Damage and Tumor Formation from Grid and Sieve Patterns of Electron and Beta Radiation in the Rat

Cited by 39 publications

References 6 publications

Progression and Multiple Events in Radiation Carcinogenesis of Rat Skin

Progression and Multiple Events in Radiation Carcinogenesis of Rat Skin

Tumor Incidence in Rat Skin Following Proton Irradiation in a Sieve Pattern.

Radiation Protection Guidelines for the Skin

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