Skin distribution of fipronil by microautoradiography following topical administration to the beagle dog

Cochet, Pascal; Birckel, P.; Bromet-Petit, Maguy; Bromet, Norbert; Weil, Angelika

doi:10.1007/bf03189809

Cited by 36 publications

(22 citation statements)

References 4 publications

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“…Unlike permethrin, a widely used acaricide, ticks are unable to detect Þpronil on topically treated animals. In addition, Þpronil has the characteristic of displacing mechanically to areas of the skin far from the site of treatment along with low percutaneous passage (Cochet et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Control of Immature Ixodes scapularis (Acari: Ixodidae) on Rodent Reservoirs of Borrelia burgdorferi in a Residential Community of Southeastern Connecticut

Dolan

Maupin²,

Schneider

et al. 2004

108

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A 3-yr community-based study was conducted on residential properties on Mason's Island, Mystic, CT, to determine the efficacy of a rodent-targeted acaricide (fipronil) to control immature Ixodes scapularis (Say) on Peromyscus leucopus. Results indicated that modified commercial bait boxes were effective as an acaricide delivery method for reducing nymphal and larval tick infestations on white-footed mice by 68 and 84%, respectively. Passive application of fipronil significantly reduced the infection rate of Borrelia burgdorferi among white-footed mice by 53%. Moreover, the abundance of questing I. scapularis adults on treated properties was reduced by 77% and fewer were infected with spirochetes (31%) compared with untreated sites (47%) after 3 yr of treatment. Likewise, the abundance of host-seeking nymphs was significantly reduced on treated properties by >50%. Finally, infection rates in flagged nymphal ticks for both B. burgdorferi and Anaplasma phagocytophilum were reduced by 67 and 64%, respectively, after only 2 yr of treatment. Results from this 3-yr trial indicate that the use of fipronil passively applied to reservoir animals by bait boxes is an environmentally acceptable means to control ticks, interrupt the natural disease transmission cycle, and reduce the risk of Lyme disease for residents of treated properties.

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Section: Discussionmentioning

confidence: 99%

Control of Immature Ixodes scapularis (Acari: Ixodidae) on Rodent Reservoirs of Borrelia burgdorferi in a Residential Community of Southeastern Connecticut

Dolan

Maupin²,

Schneider

et al. 2004

108

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“…Fipronil was only partly effective against multi‐resistant fleas on cats, whereas imidacloprid was fully effective ( Barrdt & Schein 1996). A useful feature of fipronil is its persistence in the skin, which could prevent re‐infection for weeks ( Cochet et al . 1997 ).…”

Section: Rates Of Morbidity (2 H) and Mortality (24 H) Of Pediculusmentioning

confidence: 99%

Susceptibility of British head lice, Pediculus capitis, to imidacloprid and fipronil

Downs¹,

Stafford

Coles

2000

Medical Vet Entomology

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The head louse, Pediculus capitis De Geer (Phthiraptera: Pediculidae) has developed resistance to organochlorines, the organophosphate malathion and to pyrethroids in the U.K. Therefore, headlice from Bristol school children were bioassayed against two new insecticides, fipronil and imidacloprid. Pediculus capitis was fully susceptible to imidacloprid, but it required a relatively high dose and acted slowly. Fipronil acted faster at lower dose, but seemed to be affected by cross-resistance in a small proportion of P. capitis.

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“…The majority of available treatments for dogs and/or cats are topical spot-on applications (Barnett et al ., 2008; Cadiergues et al ., 2001; Rust et al ., 2007; Young et al ., 2004). The active molecules of these topical preparations are absorbed and act systemically, or spread on the skin and act by direct contact with the arthropods (Cochet et al ., 1997). A few products are given orally like lufenuron, nitenpyram, and more recently spinosad (Dobson et al ., 2000; Kirst, 2010; Robertson-Plouch et al ., 2008).…”

mentioning

confidence: 99%

Comparative efficacy on dogs of a single topical treatment with the pioneer fipronil/(S)-methoprene and an oral treatment with spinosad againstCtenocephalides felis

Beugnet

Doyle²,

Murray³

et al. 2011

Parasite

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In the study reported here, the pioneer fipronil/(S)-methoprene topical product (FRONTLINE® PLUS, Merial Limited, Duluth, GA) was compared to the oral spinosad product (COMFORTIS® Elanco, Greenfield, IN) for efficacy against adult fleas and preventing egg production. The product presentations, doses and labelling were the one applicable in the USA. Using a standard protocol, 200 cat fleas of mixed sex were applied to dogs on Days 1, 7, 14, 21, 28, 35, and 42. Dogs were combed to remove fleas 24 hours post-infestation, the fleas were counted, collected, and then reapplied to each dog following completion of their respective count. At 48 hours post-infestation, comb counts were performed and fleas were removed. No fleas were collected from any dog in the fipronil/(S)-methoprene group at any 24 or 48 hours post-infestation assessment throughout the six weeks study, yielding a preventive efficacy of 100%. For the spinosad treatment, efficacy was 100% at 24 hours and 48 hours through Day 16, and thereafter declined. The results observed in the spinosad-treated dogs were highly variable between animals. At the 24 and 48 hours counts following the Day 21 infestation, only five of eight spinosad-treated dogs (62.5%) were flea-free. Following the Day 28 infestation, spinosad efficacy fell to 85% and 89%, for the 24 hours and 48 hours counts, and only two dogs (25%) were flea free, compared to 100% flea-free dogs in the fipronil/(S)-methoprene group. No fleas were collected from the fipronil/(S)- methoprene treated dogs throughout the entire study, therefore, no eggs were collected at any time from any dog in the group. However, in the spinosad group adult fleas were found on dogs starting on Day 21 and by Day 30, 42 eggs were collected from one dog that had 107 adult fleas counted at 48 hours. At Day 37 and Day 49, more than 100 eggs were collected from each dog in the spinosad-treated and control groups.

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Skin distribution of fipronil by microautoradiography following topical administration to the beagle dog

Cited by 36 publications

References 4 publications

Control of Immature <I>Ixodes scapularis</I> (Acari: Ixodidae) on Rodent Reservoirs of <I>Borrelia burgdorferi</I> in a Residential Community of Southeastern Connecticut

Control of Immature <I>Ixodes scapularis</I> (Acari: Ixodidae) on Rodent Reservoirs of <I>Borrelia burgdorferi</I> in a Residential Community of Southeastern Connecticut

Susceptibility of British head lice, Pediculus capitis, to imidacloprid and fipronil

Comparative efficacy on dogs of a single topical treatment with the pioneer fipronil/(S)-methoprene and an oral treatment with spinosad againstCtenocephalides felis

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