Skin Graft Size: Its Effect on Graft Survival in Mice Incompatible at a Weak Locus

Variation in the Type of Immune Response to Mouse Histocompatibility Antigens as the Function of Their Form

“…The production of serum antibodies may be expressed in terms of the titre, whereas the cell-mediated immunity has to be assessed indirectly, usually on the basis of the time taken for the rejection of a test allograft (which is supposed to be inversely proportional). The dose of the antigen may be increased by increasing the size of the allograft, but this variable seems to be important merely in weak H-systems (Lapp & Bliss, 1966). From a certain dose level (which varies with the H-system) further increasing ofthe dose of antigen no more increases its effect; the antibody production starts to decline and so does the effect on allograft survival.…”

The Non‐H‐2 Histocompatibility Loci and Their Antigens

“…Although the size of grafts exehanged across H-2 barriers does not affect graft rejection, the size of grafts exchanged across non-H'2 barriers does. Both the ability to sensitize and the time required for graft destruction , Lapp & Bliss 1966, Hildemann 1970b) are size dependent. Based on the rates of rejection of small (9 mm) and/or large (18 mm) skin grafts, Lappe et al (1969) suggested that large grafts sensitize more rapidly and take longer to reject.…”

Experimental Skin Grafts and Transplantation Immunity

“…Preliminary attempts were undertaken by Lapp and Bliss (1966) and Lappe, Graff, and Snell (1969) to evaluate the relationship between the size and survival time of skin allografts in mice incompatible at weak histocompatibility loci (H-l, H-3, or H-7) rather than the strong H-2 locus. It was determined that the survival times of skin allografts with weak incompatibility significantly improve with a progressive increase in the graft size.…”