Skin Hemangioma and Retrolental Fibroplasia

Andrews, George C.

doi:10.1001/archderm.1953.01540090082009

Cited by 14 publications

(3 citation statements)

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“…In one study of 287 infants, 25% of infants with ROP developed cutaneous hemangiomas, compared with 11% of those without ROP. 8 A study published in 1956 by Greenhouse and Szewczyk 9 also showed that cutaneous hemangiomas were more common in infants who developed ROP than in those who did not (14.3% and 7.9%, respectively). In those studies, however, because the numbers of cases were relatively small and the birth weights varied widely, the association of cutaneous hemangiomas with ROP was considered tenuous.…”

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confidence: 97%

“…In those studies, however, because the numbers of cases were relatively small and the birth weights varied widely, the association of cutaneous hemangiomas with ROP was considered tenuous. 8,9 With changes in terminology, cutaneous hemangiomas are now termed infantile hemangiomas (IHs) and are categorized as vascular tumors. In a review of the subject, Silverman 1 commented on the need to study ROP and IHs in light of the common role of oxygen-dependent angiogenic factors such as vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF) 1.…”

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Infantile Hemangiomas and Retinopathy of Prematurity: Possible Association

et al. 2009

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Infantile Hemangiomas and Retinopathy of Prematurity: Possible Association

et al. 2009

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“…Such an association was first reported in the early 1950s by Reese et al [20]. Later in that decade, a couple of other researchers also have reported a similar association between the 2 entities [21, 22]. More recently, some other studies explored the existence of such association between the 2 pathologies [8, 19].…”

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confidence: 69%

Association of Infantile Hemangiomas and Retinopathy of Prematurity: Analysis of the Multicenter KID

Dankhara¹,

Thekkeveedu²,

Patel³

et al. 2022

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Introduction: Retinopathy of prematurity (ROP) and infantile hemangiomas (IHs) both have similar proposed pathophysiological mechanisms. IH is more common in preterm than term infants. Hypoxia-induced mediators like vascular endothelial growth factor have been found elevated in children with hemangiomas. The aim of our study was to determine if there is an association between ROP and IH in preterm infants and to investigate racial/ethnic and gender differences of ROP and IHs in this cohort. Methods: We accessed the national multicenter Kids’ Inpatient Database (KID) Healthcare Cost and Utilization Project (HCUP) including admissions at age ≤28 days. Eligible infants were identified by using ICD-9 codes of ROP and IH in infants with gestational age (GA) ≤32 weeks and/or birth weight ≤1,500 g during the years 2003, 2006, 2009, and 2012. A weight-based analysis was performed using SAS Enterprise Guide 7.1 for complex sample design. Results: In the cohort of 1,068,502 eligible infants, the prevalence of IH was 4.7 per 1,000 preterm admissions (<32 weeks). ROP prevalence was 16% for GA ≤26 weeks, 12.5% for GA 27–30 weeks, and 2.7% for GA 31–32 weeks. IH was significantly higher in infants with ROP; this relationship was consistent among all stages of ROP. Regression analysis showed that females are at increased risk of IH with ROP compared to males (adjusted odds ratio [aOR]: 2.00 [1.85–2.56]). White non-Hispanic premature infants had an increased risk of IH with concomitant ROP compared to both African American (aOR: 3.9 [2.63–4.76]) and Hispanic (aOR: 1.2 [1.14–1.38]) infants. However, African American infants had an increased risk of ROP compared to white non-Hispanic infants (aOR: 1.16 [1.07–1.14]). These genders and racial/ethnic disparities were consistent among GA categories. Conclusions: To our knowledge, this is the largest cohort based on a national multicenter database comparing an association between ROP and IH. A strong association between ROP and IH may suggest similar risk factors and/or pathophysiology. A further role of genetic factors could explain racial/ethnic differences in both conditions despite similar pathogenesis. These findings may open up new bases of research for management and prevention strategies.

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