Skin-interfaced electronics: A promising and intelligent paradigm for personalized healthcare

Transdermal Drug Delivery System: Current Status and Clinical Application of Microneedles

“…Simultaneously, there is a research on multifunctional integrated intelligence, which is also a future development trend of microneedles in the medical field. Multifunctional intelligent integration refers to integrating intelligent technology with microneedle technology to achieve more functions and automation control in medical applications. These intelligent technologies can include sensors, microprocessors, wireless communication, and more, often involving multiple disciplines. − By integrating these technologies from various disciplines, it is possible to achieve automated operation, real-time monitoring, and remote control of microneedles, thereby improving the efficiency and accuracy of microneedle applications and expanding their medical applications. , However, the current research on the multifunctional integrated intelligence of microneedles is still in its early stages and generally focuses on combining sensor monitoring and drug delivery. Therefore, it can only achieve relatively simple environmental stimulus responses and basic indicator detection, and it cannot effectively respond to complex clinical environmental factors, thus having certain limitations.…”

Functional electrospun nanofibers: fabrication, properties, and applications in wound-healing process

“…Commonly used antimicrobial additives include antimicrobial metal nanoparticles, such as zinc oxide nanoparticles (ZnONPs), 91,92 silver nanoparticles (AgNPs), 93 and silver oxide (Ag 2 O). A study found that the use of PLA nanofibers containing nanosilver significantly promoted the healing of skin wounds in mice, 94,95 which was attributed to the fact that nanosilver could kill bacteria in the wounds, and at the same time, the high specific surface area of nanofibers could increase the contact area between the cells and the ECM, which could promote the regeneration of cells and healing.…”

Emerging Energy Harvesters in Flexible Bioelectronics: From Wearable Devices to Biomedical Innovations

“…The field of flexible electronics has witnessed accelerated progress in the last decade. [1,2] Flexible electronics have been designed and developed to replace the conventional rigid and bulky electronics that seamlessly interface with the human body for versatile biomedical innovations, including wearable sensors, [3][4][5][6] stretchable displays, [7,8] and digital medicine. [9,10] With the rapid development of machine learning, additive manufacturing, and semiconductor production, flexible electronics have evolved into a more miniaturized, personalized, and accurate toolbox used in intelligent healthcare management, smart agriculture, and the Internet of Medical Things.…”