Skin lesions associated with Fusarium infection

Bodey, Gerald P.; Boktour, Maha; Mays, Steven R.; Duvic, Madeleine; Kontoyiannis, Dimitrios P.; Hachem, Ray; Raad, Issam

doi:10.1067/mjd.2002.123489

Cited by 104 publications

(97 citation statements)

References 19 publications

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“…The Czapeck-dox liquid medium, which is chemically defined, was suitable for stimulating the production of this type of metabolite produced by Fusarium, in accordance with reports by other investigators (18)(19)(20)(21)(22)(23)(24)(25).…”

Section: Discussionsupporting

confidence: 70%

“…This study, with a clinical isolate taken from a case of human onychomycosis, confirms the potential of this species to cause diseases in both plant and animal tissue (20). Several investigators have described a marked inflammatory reaction characterized by a necrotic aspect and accompanied by pain, in various human infections caused by Fusarium (6,(21)(22)(23).…”

Section: Discussionmentioning

confidence: 78%

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Toxic thermoresistant metabolites of Fusarium oxysporum are capable of inducing histopathological alterations in Wistar rats

Hernandes¹,

Marangon²,

Salci³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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Abstract:The genus Fusarium is known to produce mycotoxins that cause fusariosis in plants, animals and humans. Mycotoxins are among the virulence factors of this genus. Metabolic extracts of Fusarium oxysporum, isolated from a patient with onychomycosis and sterilized by filtration or autoclave, were inoculated intradermally into Wistar rats at concentrations of 0.25, 0.5 and 1 μg/μL, and the effects on their tegument were observed at 24 and 72 hours. After histological procedures and staining by hematoxylineosin, the sections were studied for their inflammatory-reaction intensity and for evidence of injury and tissue distortion. Inflammatory reactions in the dermis and the subcutaneous tissue were observed at all concentrations of the inoculated extract tested. There was a significant influx of neutrophils, mastocytes and lymphocytes, as well as a large quantity of macrophages. Apoptotic bodies and hyperemic blood vessels were observed. This reaction was directly related to the extract concentration, and was most intense in animals that received the 1 mg/µL dose. The maximum peak was observed at 24 hours. The autoclaved metabolic extract produced the same effects as the untreated one, indicating the presence of heat-resistant metabolites. In conclusion, the metabolic extracts obtained from sterilized culture filtrates of F. oxysporum are capable of inducing an inflammatory response within 24 hours in the dermis and subcutaneous tissue of rats.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 78%

Toxic thermoresistant metabolites of Fusarium oxysporum are capable of inducing histopathological alterations in Wistar rats

Hernandes¹,

Marangon²,

Salci³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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“…Diagnosis is established by culture and visualization of irregularly shaped broad nonseptate hyphae with right angle branching. These organisms are usually found along with a neutrophilic infiltrate and within vessels [9].…”

Section: Types Of Invasive Fungal Lesionsmentioning

confidence: 99%

“…While it is uncommon to isolate Aspergillus in blood cultures of patients with disseminated infection, Fusarium can be isolated in 70% of patients with disseminated infection. Finally, disseminated Fusarium typically (75-90%) produces skin lesions while they are uncommon in disseminated Aspergillus [5,9].…”

Section: Types Of Invasive Fungal Lesionsmentioning

confidence: 99%

Invasive cutaneous fungal infections requiring radical resection in cancer patients undergoing chemotherapy

Radhakrishnan

Donato

Prieto

et al. 2004

Journal of Surgical Oncology

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Invasive fungal infections have emerged as a significant problem in patients with cancer with the development of better systemic therapies for malignancy and more effective antibacterial agents. The currently available world published medical literature was reviewed on invasive fungal infections in cancer patients with specific attention devoted to the multidisciplinary role of surgery in refractory cutaneous cases. Infections can develop on the forearm where peripheral intravenous catheters had been inserted in cancer patients undergoing cytotoxic chemotherapy. Curative intent begins with systemic contemporary anti-fungal therapy. Following resolution of neutropenia, patients may require radical surgical debridement with negative margins of resection for complete eradication of the fungal infection. Although invasive fungal infections refractory to antifungal systemic therapy in immunocompromised patients undergoing chemotherapy are a rare event, it is critical for surgeons and other multidisciplinary clinicians to recognize these potentially life-threatening infections that may necessitate radical surgical resection for cure.

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“…Despite the fact that skin is not typically the site of primary infection, cutaneous involvement is common in disseminated fusariosis, and skin lesions are present in greater than 70% of patients (Nucci and Anaissie, 2002). Several morphological variants of cutaneous Fusarium have been described, although painful erythematous papules or nodules are most common, and many lesions have an eschar or central necrosis (Nucci and Anaisse, 2007;Bodey et al, 2002). Even when characteristic skin lesions are present, however, Fusarium is often clinically indistinguishable from Aspergillosis.…”

Section: Casementioning

confidence: 99%

Disseminated <i>Fusarium</i> Infections in Patients Receiving Posaconazole Prophylaxis: A Report of 2 Patients and Brief Review of the Literature

Fournier¹,

Thomas²,

Breen³

et al. 2015

American Journal of Infectious Diseases

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Fusarium is a filamentous fungi that has emerged as a frequent cause of invasive infections in immunocompromised patients. Dermatologists often play a critical role in diagnosing fusariosis, as greater than 70% of patients with disseminated infections have cutaneous involvement, and microbiologic evaluation of skin specimens provides the diagnosis in the majority of cases. Second-generation triazoles are typically the most effective medications in treating invasive Fusarium infections, and we discuss the benefits of using these medications, as well as detail the side effects of these therapeutic agents.

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Skin lesions associated with Fusarium infection

Cited by 104 publications

References 19 publications

Toxic thermoresistant metabolites of Fusarium oxysporum are capable of inducing histopathological alterations in Wistar rats

Toxic thermoresistant metabolites of Fusarium oxysporum are capable of inducing histopathological alterations in Wistar rats

Invasive cutaneous fungal infections requiring radical resection in cancer patients undergoing chemotherapy

Disseminated <i>Fusarium</i> Infections in Patients Receiving Posaconazole Prophylaxis: A Report of 2 Patients and Brief Review of the Literature

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