Skin-like wound dressings with on-demand administration based onin situpeptide self-assembly for skin regeneration

Abstract

Burn injuries without the normal skin barrier usually cause skin wound infections, and the wound dressings are necessary treatment. Although various dressings with antibacterial ability have already been developed, the...

In situ peptide assemblies for bacterial infection imaging and treatment

“…Similarly, the authors used gelatinase to trigger a wound dressing to release a peptide monomer containing a (KLAKLAK) 2 sequence. 98 The released peptide monomer subsequently self-assembled into fibrous nanostructures in situ , enabling efficient sterilization in wound infections. In another recent work, Du et al developed a peptide precursor WRWRWY consisting of three hydrophobic tryptophans (W), two arginines (R) with positively charged side chains, and a tyrosine for tyrosinase (an overexpressed enzyme in the human skin) oxidation.…”

Implantable and biodegradable closed‐loop devices for autonomous electrotherapy

“…These advantages are driving the broad applications of implantable devices in the fields of smart gastric and cardiac pacemakers, cochlear implants, implantable cardioverter defibrillators, and brain–computer interactions 3 . Therefore, realizing superior implantable device properties is both an opportunity and a challenge for medical and healthcare delivery, particularly autonomous electrotherapy of cardiac disease 1,4,5 . As the cornerstone of cardiac disease therapy, existing platforms have significant limitations as they rely on conventional electronic hardware, monitoring systems, and interfaces to the body.…”

“…3 Therefore, realizing superior implantable device properties is both an opportunity and a challenge for medical and healthcare delivery, particularly autonomous electrotherapy of cardiac disease. 1,4,5 As the cornerstone of cardiac disease therapy, existing platforms have significant limitations as they rely on conventional electronic hardware, monitoring systems, and interfaces to the body. First, bacteria can form a biofilm on the device, posing a risk of infection.…”

Two-Layered Biomimetic Flexible Self-Powered Electrical Stimulator for Promoting Wound Healing

“…Currently, wound healing methods, such as advanced growth factor-mediated therapy, structure imitation of the natural extracellular matrix, optimization of the cell-growing environment, and use of bioactive materials, are effective for skin regeneration; however, these methods still have the challenges of inaccurate control and biological activity loss. With the elucidation of wound healing, both wound dressing and treatment strategies have been constantly developing . In the field of wound healing, researches have focused on methods to rapidly, safely, and effectively treat skin wounds, accelerate healing, and improve healing quality …”