Skin lipids in health and disease: A review

Knox, Sophie; O’Boyle, Niamh M.

doi:10.1016/j.chemphyslip.2021.105055

Cited by 107 publications

(107 citation statements)

References 137 publications

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“…Overall, psoriatic lesions have elevated lipid levels [ 54 ]. These findings differ from the stratum corneum lipid dysregulation in atopic dermatitis lesions, which feature reduced levels of total skin lipid and ceramide [ 56 ]. However, the relative proportions of lipids in uninvolved skin in those with psoriasis, atopic dermatitis and no skin disease are comparable [ 57 ].…”

Section: Barrier Aberration In Psoriasismentioning

confidence: 84%

Skin Barrier Dysregulation in Psoriasis

Andreas

Bereza-Malcolm

Lynch

et al. 2021

IJMS

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The skin barrier is broadly composed of two elements—a physical barrier mostly localised in the epidermis, and an immune barrier localised in both the dermis and epidermis. These two systems interact cooperatively to maintain skin homeostasis and overall human health. However, if dysregulated, several skin diseases may arise. Psoriasis is one of the most prevalent skin diseases associated with disrupted barrier function. It is characterised by the formation of psoriatic lesions, the aberrant differentiation and proliferation of keratinocytes, and excessive inflammation. In this review, we summarize recent discoveries in disease pathogenesis, including the contribution of keratinocytes, immune cells, genetic and environmental factors, and how they advance current and future treatments.

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Section: Barrier Aberration In Psoriasismentioning

confidence: 84%

Skin Barrier Dysregulation in Psoriasis

Andreas

Bereza-Malcolm

Lynch

et al. 2021

IJMS

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“…The skin appendages are skin-associated structures including hair follicles, nails, and glands (sebaceous and sweat) [7]. The extracellular space of the epidermis is dominated by lipids, mostly ceramides, acyl ceramides, cholesterol, cholesterol esters, and non-esterified fatty acids (NEFA) [4].…”

Section: Lipids Of the Skinmentioning

confidence: 99%

“…Balanced skin lipid composition is necessary for barrier integrity and stability, antimicrobial activity, and pH maintenance. Nowadays it is widely accepted that abnormalities in skin lipid composition is associated with several diseases such as acne vulgaris, rosacea, atopic dermatitis, and psoriasis [2][3][4]. Furthermore, microbiome diversity is a key mediator of skin wellness and health.…”

Section: Introductionmentioning

confidence: 99%

Revealing the Correlation between Altered Skin Lipids Composition and Skin Disorders

et al. 2021

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Human skin layers serve as a barrier between the body and the environment, by preventing water loss and blocking the entry of chemicals, allergens, and microbes. Recent data showed that skin lipids are vital ‘key players’ of several functions and mechanisms performing in the skin, such as, barrier function and microbiome composition. Abnormalities in lipid composition have been observed in inflammatory cutaneous diseases with a disrupted skin barrier. This review aims to demonstrate the fundamental role of keratinocytes, sebocytes, and microbiome-derived lipids in the maintenance of the skin barrier. Furthermore, it would reveal the correlation between altered skin lipids’ composition, microbiome, and the occurrence of certain dermatological disorders such as acne vulgaris, atopic dermatitis, psoriasis, and rosacea.

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“…Skin lipids are critical to the structure and function of the skin. Starting from the depth of the hypoderm, through the ceramide-rich epidermis and ending with lipids on the skin surface, there are a huge number of different lipids playing important roles [7]. Thus, 3 main types of structures can be distinguished in the skin, actively producing and secreting fats and fat-like substances.…”

Section: Introductionmentioning

confidence: 99%

Lipid-containing and lipid-synthesizing structures of the young Poltava Meaty Breed boars’ skin

et al. 2021

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The fulfillment of a number of the most important physiological functions of the skin is directly related to skin lipids. This article presents the results of studying the lipid-containing and lipid-synthesizing structures of the young Poltava Meat Breed boars’ skin. Morphofunctional epidermis features, sebaceous glands and adipose tissue cells of the hypodermis and their relationship with other skin structures were studied. The boars of Poltava Meat Breed, upon reaching the live weight of 100 kg, have certain specific features of skin structure, which plays an important role for developing efficient methods of selectioning, breeding and keeping the animals, which would raise the functional abilities of highly productive animals and help obtaining high-quality production from them.

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Skin lipids in health and disease: A review

Cited by 107 publications

References 137 publications

Skin Barrier Dysregulation in Psoriasis

Skin Barrier Dysregulation in Psoriasis

Revealing the Correlation between Altered Skin Lipids Composition and Skin Disorders

Lipid-containing and lipid-synthesizing structures of the young Poltava Meaty Breed boars’ skin

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