Skin Manifestations and Coeliac Disease in Paediatric Population

Persechino, Flavia; Galli, G.; Valitutti, Francesco; Zenzeri, Letizia; Mauro, Angela; Corleto, Vito D.; Parisi, Pasquale; Ziparo, Chiara; Evangelisti, Melania; Quatrale, Giovanna; Nardo, Giovanni Di

doi:10.3390/nu13103611

Cited by 15 publications

(13 citation statements)

References 137 publications

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“…The pathognomonic histology with immunohistochemistry or immunofluorescence shows granular IgA deposits and neutrophil infiltrates in the papillary dermis. Almost 85% of these patients with a Caucasian ethnicity carry HLA-DQ2 mutations while the remaining have HLA-DQ8[ 42 ]. Typically, only two-third patients with DH have villous abnormalities and one third of them have no enteropathy[ 43 ].…”

Section: Definite Indications For Screening For Cedmentioning

confidence: 99%

Who to screen and how to screen for celiac disease

Singh¹,

Singh²,

Ahuja³

et al. 2022

WJG

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Celiac disease (CeD) is a chronic gluten-induced enteropathy with plethoric manifestations. The typical manifestations of CeD such as chronic diarrhea and malabsorption are widely recognized, however, many patients have atypical manifestations like iron deficiency anemia, idiopathic short stature, hypertransaminesemia or infertility, etc. These patients often present to the primary care physicians and/or non-gastrointestinal specialties. However, due to a lack of awareness among the healthcare professionals about the various atypical manifestations, many patients are not screened for CeD. In this review, we have summarized the available literature about the prevalence of CeD in various gastrointestinal (chronic diarrhea) and non-gastrointestinal conditions (iron deficiency anemia, short stature, cryptogenic hypertransaminesemia, cryptogenic cirrhosis or idiopathic ataxia etc. ) where the diagnosis of CeD should be con-sidered. In addition, we also discuss special scenarios where screening for CeD should be considered even in absence of symptoms such as patients with type 1 diabetes, Down’s syndrome, and first-degree relatives of patients with CeD. Further, we discuss the diagnostic performance and limitations of various screening tests for CeD such as IgA anti-tissue transglutaminase antibodies, anti-endomysial antibodies and anti-deamidated gliadin antibodies. Based on the current recommendations, we propose a diagnostic algorithm for patients with suspected CeD.

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Section: Definite Indications For Screening For Cedmentioning

confidence: 99%

Who to screen and how to screen for celiac disease

Singh¹,

Singh²,

Ahuja³

et al. 2022

WJG

View full text Add to dashboard Cite

show abstract

“…CD is considered a childhood disease, however, up to 20% of adults diagnosed with CD are over 60 years of age [16]. CD manifests itself in a wide range of typical and atypical ways [17][18][19][20][21]. For more than three decades, the CD has been persistently underdiagnosed, and its clinical presentation has changed, leading to difficulties with CD diagnosis [17].…”

Section: Discussionmentioning

confidence: 99%

Serum and salivary tissue transglutaminase IGA (tTG-IGA) level in celiac patients

et al. 2022

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Background Celiac disease (CD) is a genetically determined autoimmune disease triggered by gluten consumption. Patients with these conditions have intraepithelial lymphocytosis, crypt hyperplasia, and severe intestinal atrophy. Gluten elimination is the only way to reduce this chronic inflammation. The diagnosis of CD is usually made by analyzing anti-tTG, anti-DGP, or EMA serological tests, and it is confirmed by biopsy of the duodenum. In people with CD, xerostomia or dry mouth is a common complication. This condition causes the salivary glands to malfunction and, in turn, may result in oral plaque and periodontal disease. By comparing salivary and serum levels of tissue transglutaminase IgA (tTG-IgA), this study aims to suggest a non-invasive method for diagnosis of CD. Furthermore, the present study evaluates the severity of xerostomia symptoms in people with CD. Methods In this case–control study, participants were patients referred to the internal ward of Sayyad Shirazi hospital. The control group was selected from healthy people who attended Gorgan Dental College. In this study, an analysis of serum was performed following consent from patients. This was followed by a salivary test, and the results of both tests were compared. The Xerostomia Inventory questionnaire was also used to determine the severity of xerostomia. As part of this study, examination of factors such as total protein concentration of saliva, albumin concentration, amylase level, pH, sodium, calcium, potassium, phosphorus, and interleukin (6, 18, and 21) were conducted. Results A total of 78 people were studied (aged 15 to 68), 26 were male (33.3%) and 52 were female (66.7%). In comparisons of the serum and saliva of people with and without CD, the level of amylase was higher in the latter group. The average levels of IL-6، IL-18 ،IL-21, and salivary and serum tTG were higher in people with CD. Additionally, CD patients were more likely to develop xerostomia. Conclusion Study findings showed that CD can reduce certain salivary enzymes and elements, as well as increase inflammatory cytokines, salivary, and serum tTG. The management of dry mouth should also be recommended for celiac disease patients in order to prevent its complications.

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“…Previous cohort studies showed a prevalence of DH to be 17–20% in untreated CD [ 23 , 24 , 25 ], however, in 2017, a 10-year cohort study in Finland showed a prevalence of only 4% [ 26 ]. Other dermatologic associations can include psoriasis [ 27 ], urticaria [ 28 ], leukocytoclastic vasculitis [ 29 ], alopecia areata, atopic dermatitis and hereditary angioneurotic oedema [ 30 ].…”

Section: Celiac Diseasementioning

confidence: 99%

A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment

et al. 2022

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Celiac disease (CD) is a common chronic inflammatory disorder occurring in genetically predisposed individuals secondary to gluten ingestion. CD usually presents with gastrointestinal symptoms such as pain, bloating, flatulence, and constipation or diarrhea. However, individuals can present in a nonclassical manner with only extraintestinal symptoms. The neurological manifestations of CD include ataxia, cognitive impairment, epilepsy, headache, and neuropathy. A lifelong gluten-free diet is the current recommended treatment for CD. This review discusses the relevant neurological manifestations associated with CD and the novel therapeutics. Further research is required to get a better understanding of the underlying pathophysiology of the neurological manifestations associated with CD. Clinicians should keep CD in the differential diagnosis in individuals presenting with neurological dysfunction of unknown cause.

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Skin Manifestations and Coeliac Disease in Paediatric Population

Cited by 15 publications

References 137 publications

Who to screen and how to screen for celiac disease

Who to screen and how to screen for celiac disease

Serum and salivary tissue transglutaminase IGA (tTG-IGA) level in celiac patients

A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment

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