Skin manifestations associated with kidney cancer

Amin, Asim; Burgess, Earle F.

doi:10.1053/j.seminoncol.2016.02.016

Cited by 9 publications

(7 citation statements)

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“…Vascular endothelial growth factor plays a substantial role in RCC growth; hence, primary tumors as well as metastases tend to be extremely vascular. [14]…”

Section: Discussionmentioning

confidence: 99%

Nodular lesions on the upper trunk: An uncommon anatomical site of renal tumor metastases

et al. 2019

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Renal cell carcinoma (RCC) is the most frequent cancer of the kidney and it accounts for 3% of all solid malignancies. Although rare, cutaneous metastases can be an important manifestation of RCC. We present a case of a 56-year-old male with a history of RCC, followed by the development of cutaneous metastases 4 years later with an uncommon clinical presentation. RCC is the most common genitourinary cancer to metastasize to the skin and accounts for 6.8% of cutaneous metastases. These patients have a poor prognosis. It is essential for these patients to perform a complete periodic dermatologic examination for proper restaging and treatment.

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“…Vascular endothelial growth factor plays a substantial role in RCC growth; hence, primary tumors as well as metastases tend to be extremely vascular. [14]…”

Section: Discussionmentioning

confidence: 99%

Nodular lesions on the upper trunk: An uncommon anatomical site of renal tumor metastases

et al. 2019

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“…Cutaneous metastasis is seen in 3%–7% of patients 5. Cutaneous paraneoplastic syndromes have also been reported with RCC and include bullous dermatosis, dermatomyositis, Henoch-Schönlein purpura, cutaneous sarcoidosis and cutaneous vasculitis 6. Association of cutaneous vasculitis with RCC has been rarely reported in literature.…”

Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma with sarcomatoid transformation, presenting as skin rashes

Shrivastava

Nayak²,

Singh

2018

BMJ Case Reports

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A 68-year-old man presented to our outpatient department, with chief complaints of rashes all over the body. On physical examination, purpuric rashes were present over all four limbs and a lump was palpable in right flank. Contrast-enhanced CT scan showed enhancing large right renal mass. He underwent right radical nephrectomy, and histopathological analysis showed features of renal cell carcinoma. Skin lesions disappeared after surgery.

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“…Furthermore, RCC growth is associated with vascular endothelial growth factor, which explains its ability to disseminate widely and form highly vascular dermal metastasis. 1 , 7 …”

Section: Discussionmentioning

confidence: 99%

“…Lesions are clinically challenging to diagnose, as they may resemble epidermoid cysts, fibromas, or vascular tumors such as Kaposi sarcoma, hemangioma, or pyogenic granuloma. 1 , 7 Given the uncharacteristic location of the lesions in our patient, we initially considered pyogenic granuloma secondary to treatment with sunitinib as the leading differential diagnosis, as several receptor tyrosine kinase inhibitors were recently reported to be associated with this vascular lesion. 8 However, histologically, RCC tumor nodules are composed of clear-staining tumor cells within a highly vascular stroma, as was seen in our patient.…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 60,000 new diagnoses of renal cell carcinoma (RCC) are made per year, accounting for 90% to 95% of all malignant neoplasms arising from the kidney with an estimated mortality rate of 20%. 1 Rarely, advanced RCC may exhibit cutaneous metastases, most often to the scalp, chest, arms, and fingers. 1 , 2 We discuss an unusual case of cutaneous metastatic RCC involving the penis, presenting as multiple exophytic pyogenic granuloma-like lesions.…”

Section: Introductionmentioning

confidence: 99%

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