Skin manifestations of endocrine diseases

Demirkesen, Cüyan

doi:10.5146/tjpath.2015.01321

Cited by 6 publications

(16 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The generation of artificial skin substitutes by tissue engineering is challenging 8 – 10 . However, the prevalence of pathologies affecting the skin, such as cancer, traumatic injuries or infections 4 , 5 , 30 , 31 , makes it necessary to search for improved models of bioartificial skin able to contribute to the treatment of these conditions. In recent decades, several improvements have been described in biofabrication procedures for artificial skin 20 , 32 .…”

Section: Discussionmentioning

confidence: 99%

Development of secretome-based strategies to improve cell culture protocols in tissue engineering

Cases-Perera

Blanco-Elices

Chato‐Astrain

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Advances in skin tissue engineering have promoted the development of artificial skin substitutes to treat large burns and other major skin loss conditions. However, one of the main drawbacks to bioengineered skin is the need to obtain a large amount of viable epithelial cells in short periods of time, making the skin biofabrication process challenging and slow. Enhancing skin epithelial cell cultures by using mesenchymal stem cells secretome can favor the scalability of manufacturing processes for bioengineered skin. The effects of three different types of secretome derived from human mesenchymal stem cells, e.g. hADSC-s (adipose cells), hDPSC-s (dental pulp) and hWJSC-s (umbilical cord), were evaluated on cultured skin epithelial cells during 24, 48, 72 and 120 h to determine the potential of this product to enhance cell proliferation and improve biofabrication strategies for tissue engineering. Then, secretomes were applied in vivo in preliminary analyses carried out on Wistar rats. Results showed that the use of secretomes derived from mesenchymal stem cells enhanced currently available cell culture protocols. Secretome was associated with increased viability, proliferation and migration of human skin epithelial cells, with hDPSC-s and hWJSC-s yielding greater inductive effects than hADSC-s. Animals treated with hWJSC-s and especially, hDPSC-s tended to show enhanced wound healing in vivo with no detectable side effects. Mesenchymal stem cells derived secretomes could be considered as a promising approach to cell-free therapy able to improve skin wound healing and regeneration.

show abstract

Section: Discussionmentioning

confidence: 99%

Development of secretome-based strategies to improve cell culture protocols in tissue engineering

Cases-Perera

Blanco-Elices

Chato‐Astrain

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…El sistema endocrino, la piel y sus anejos interaccionan a través de una compleja cohorte de mecanismos, lo cual nos deja una enorme variedad de signos cutáneos asociados a las patologías endocrinológicas que no solo generan una importante morbilidad en sí mismos, sino que también pueden ser clave para facilitar una detección temprana de dichas enfermedades 1,3 . Encontramos manifestaciones derivadas tanto del exceso como de la deficiencia de determinadas hormonas, y patologías dermatológicas cuya incidencia aumenta en determinados grupos de pacientes endocrinológicos 4 .…”

Section: Introductionunclassified

“…Destaca la acantosis nigricans, asociada entre otras a diabetes mellitus (DM), acromegalia 1,4 , hiperprolactinemia 4 , síndrome de Cushing 4,5 , síndrome metabólico (SMet) [6][7][8][9] y síndrome de ovario poliquístico (SOP) 1,4 . Otras manifestaciones son más específicas de una única enfermedad endocrina, como por ejemplo la dermopatía diabética o las ampollas del diabético en la DM, o las estrías rojo-vinosas en el síndrome de Cushing.…”

Section: Introductionunclassified

Manifestaciones cutáneas en patologías endocrino-metabólicas

Segurado-Tostón¹,

Revelles-Peñas²,

Arriba³

et al. 2023

MCUT

View full text Add to dashboard Cite

El dermatólogo puede observar en ocasiones ciertos signos que pueden ser clave para el diagnóstico y la monitorización de determinadas enfermedades endocrinológicas. La piel y el sistema endocrino interaccionan mediante múltiples mecanismos, generando diversas manifestaciones. Analizar y actualizar la evidencia existente en la literatura sobre las manifestaciones cutáneas en enfermedades endocrinológicas para realizar un diagnóstico precoz y, si se requiere, el tratamiento de estas enfermedades. Revisión de la literatura existente, un total de 22 artículos identificados mediante los motores de búsqueda PubMed, Science Direct y Springer. Se incluyen solo artículos de revisión o casos reportados publicados en los 6 años previos a junio de 2021. Hallamos evidencia de beneficios con el cribado de diabetes mellitus en pacientes con acantosis nigricans, acrocordones, ampollas del diabético, necrobiosis lipoídica, dermatosis ictiosiforme o prurito; así como del cribado de microangiopatía diabética en presencia de dermopatía diabética, ampollas del diabético, necrobiosis lipoídica, eritema facial, eritema palmar, dermatosis ictiosiforme, dermatosis perforante, telangiectasias periungueales o prurito. Varios de los artículos revisados coinciden acerca de la existencia de asociación significativa entre psoriasis, acné, hidrosadenitis supurativa y liquen y síndrome metabólico con el síndrome de ovario poliquístico, así como entre el vitíligo y las diversas patologías asociadas al síndrome poliglandular autoinmunitario. Únicamente cinco de los artículos revisados aportaron evidencia respecto al papel de la piel en patologías de tiroides y del eje hipotalámico-hipofisario.

show abstract

“…Some of these skin diseases are primary localized cutaneous amyloidosis (PLCA) and acquired perforating dermatosis (APD). 3 Amyloidosis is a group of diseases caused by the deposition of misfolded protein, called amyloid, in certain tissues. The amyloid deposition that is confined to the skin is called PLCA.…”

Section: Introductionmentioning

confidence: 99%

“…Some of these skin diseases are primary localized cutaneous amyloidosis (PLCA) and acquired perforating dermatosis (APD). 3 …”

Section: Introductionmentioning

confidence: 99%

Coexistent Lichen Amyloidosis and Acquired Reactive Perforating Collagenosis in Type 2 Diabetes Mellitus and Post-Thyroidectomy Hypothyroidism Due to Papillary Thyroid Carcinoma: A Rare Case

Sutedja¹,

Widjaya²,

Dharmadji³

et al. 2022

IMCRJ

View full text Add to dashboard Cite

An abundance of endocrine receptors is expressed on the skin and becomes the target of many hormones. This was associated with various skin diseases that might occur in some endocrine diseases eg, lichen amyloidosis (LA) and acquired reactive perforating collagenosis (ARPC). Here, we report a coexistent LA and ARPC in a 55-year-old woman, characterized with multiple pruritic hyperkeratotic papules and plaques on both arms accompanied by pruritic hyperkeratotic papules and nodules on both legs. She had a history of type 2 diabetes mellitus (DM) and post-thyroidectomy hypothyroidism due to papillary thyroid carcinoma. Histopathological examination revealed amyloid deposition in the papillary dermis corresponding with LA and cup-shaped epidermal depression filled with collagen corresponding with ARPC. The hyperkeratotic papules and nodules flattened in one month after application of 0.05% clobetasol propionate ointment with occlusion on both arms and 0.05% retinoic acid gel on both legs. Hyperkeratotic papules, nodules, and plaques in a patient with a history of endocrine diseases, such as type 2 DM and thyroid disorders should undergo histopathological examination to confirm the diagnosis of skin diseases eg, LA or ARPC.

show abstract

Skin manifestations of endocrine diseases

Cited by 6 publications

References 16 publications

Development of secretome-based strategies to improve cell culture protocols in tissue engineering

Development of secretome-based strategies to improve cell culture protocols in tissue engineering

Manifestaciones cutáneas en patologías endocrino-metabólicas

Coexistent Lichen Amyloidosis and Acquired Reactive Perforating Collagenosis in Type 2 Diabetes Mellitus and Post-Thyroidectomy Hypothyroidism Due to Papillary Thyroid Carcinoma: A Rare Case

Contact Info

Product

Resources

About