Skin Metastases in Ovarian Carcinoma: A Report of Nine Cases and a Review of the Literature

Skin metastasis in ovarian carcinoma

“…However, cutaneous metastasis might be observed even 6 years after diagnosis of ovarian cancer (10) . Similar to Cormio's study (5) , in our case the interval time was 24 months. A retrospective chart review conducted on 162 patients with epithelial ovarian cancer by Cormio et al concluded that at the time of diagnosis of distant metastasis, 72% of the patients had concurrent intraperitoneal disease, and the prognosis after documentation of distant metastasis is poor (15) .…”

“…The most common sites of distant metastasis are the pleura, liver, lung, and lymph nodes, and skin metastasis occur in 3.5% of patients with ovarian carcinoma (3) . There are other studies reporting percentage of cutaneous metastasis for ovarian carcinoma ranging from 1.9 to 5.1%, but the number of patients studied is insufficient (4,5) .…”

“…Theories that try to explain the pathogenesis of skin metastasis in ovarian cancer are direct invasion from the underlying growth and contiguous extension of the tumor cells throughout lymphatics (4,5,(12)(13)(14)(15) . Typically, the histology of inflammatory skin metastasis demonstrates the presence of tumor cells in the subepidermal lymphatic vessels, and this causes obstruction, lymphedema, and erythema (12) .…”

Perforating cutaneous metastasis from an ovarian adenocarcinoma

“…Ovarian carcinoma is the third most common gynecological cancer. It involves the skin in 1.9-5.1% of cases 11,12 and accounts for 4-10% of all cutaneous metastasis in females. 3,7,10 The majority of ovarian cancers are of epithelial origin (94%).…”

Peritoneal Catheter Site Metastasis in a Patient With Advanced Ovarian Cancer

“…Four other cases of ovarian cancer metastases related to peritoneal access chemotherapy catheters were reported in the literature. 3,4 The incidence of peritoneal catheter tract metastasis in ovarian cancer is unknown. Correspondingly, the effect of catheter tract metastases on the overall survival is also unknown.…”