Skin Microbiota Transplantation by Nivea Refining Clear-Up Strips Could Reverse Erythema Scores in Dogs with Atopic Dermatitis: Novel Strategy for Skin Microbiome Manuplation: Cohort Study

Abstract

Skin microbiota transplantation (SMT) has aroused our interest for several years, with clinical trials. In the present study the purposes were i) to examine the practicability of SMT by Nivea Refining Clear-Up Strips able to transfer unenriched skin microbiota communities and, ii) to analyze the efficacy of SMT on erythema scores comparatively. Material and Methods: Briefly SMT was repeated on days 5 and 12, and the results were compared to initial values. In a total of 4 different healthy anatomical locations of the same case were selected, the strips were placed on moistened skin and allowed them to dry for 10-12 minutes. Then were carefully peeled off, all 4 strips were transferred to the erythema involved skin tissue were also moistured and allowed to attach for at least 12-15 minutes. The skin erythema severity was estimated with visual analogue scale erythema severity score (VAS-ESS) and Atopic Dermatitis Area and Severity Index (ADASI). Results: The Pearson correlations between the factor scores were all above 0.22 and statistically significant (p<0.001) between day 5 ADASI and VAS-ESS scores (r=0.033) and between day 5 ADASI and day 12 VAS-ESS scores (r=0.048, p<0.001). Conclusion:In conclusion by use of SMT ADASI and VAS-ESS scores were decreased. Transfer of skin microbiota between 2 dissimilar autologous microenvironments for each case (at the same host) enrolled would have helped hastening clinical recovery in dogs with atopic dermatitis.

Unenriched skin microbiota transplantation for cats: new road story for treating feline atopic skin syndrome

“…Moreover, by use of Ni-RcUs, we might probably have depleted pathogenic bacteria during transplantation to the donor, as because Ni-RcUs composed of citric acid. Same researcher group of this study, publishing another study (Ctrl X, Ctrl C and Ctrl V in Veterinary Dermatology: Splendiferous Era of Dermatology Art by Skin Microbiota Transplantation among Dogs with Cutaneous Adverse Food Reactions; under revision at the time of writing this manuscript) in which denoted that Ni-RcUs with its citric acid content could a) decorate superficial layers of old fashioned skin components ( Ural et al, 2023 ), b) impede pseudomonas ceramidase ( Inoue et al, 2010 ), c) diminish local pH in a similar manner to intestinal tract, as defined previously ( Xue et al, 2023 ; Russel & Diez-Gonzalez, 1997) through declined colony of pathogens, via penetration to pathogenic cell wall consequently suppressed growth/reproduction ( Xue et al, 2023 ; Russel & Diez-Gonzalez, 1997) and d) probably increase number of beneficial bacteria. The latter finding must be briefly discussed for better understanding of the readers.…”

“…The latter algorithm involved novel terminology regarding FASS, establishing updated denotation of allergy, gastrointestinal and respiratory disorders among cats (Mueller et al, 2021). Under this classification FASS was dedicated to allergic dermatological issues in relationship with environmental allergy ( Santoro et al, 2021 ; Ural et al, 2019a , 2019b ; Ural et al, 2022a , 2022b ; Ural et al, 2023 ). For detailed diagnosis of FASS, classification ( Santoro et al, 2021 ) was performed in agreement with other data ( Diesel & DeBoer, 2011 ; Favrot et al, 2014 ; Ravens et al, 2014 ).…”

“…Decision was based on even if there was a healthy donor at the time of clinical application. Even if heterologous intervention was applied partial hair on skin with apparently healthy donor from a minimum of 4 different anatomical area with contrast composition ( Ural et al, 2022a , 2022b ; Ural et al, 2023 ) were shaved. If there was no donor at that time, diseased cat was transferred by its own skin microbiota as autologous intervention.…”