2019
DOI: 10.1186/s13601-019-0262-y
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Skin microdialysis: methods, applications and future opportunities—an EAACI position paper

Abstract: Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being available since the 1990s, the technique has still not reached its full potential use as a tool to explore pathophysiological mechanisms of allergic and inflammatory reactions in the skin. Therefore, an EAACI Task Forc… Show more

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Cited by 31 publications
(19 citation statements)
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“…Since classical microdialysis already allowed insights into tissue-specific drug [ 28 ] and cytokine levels [ 29 ], the automated determination of pharmacokinetic profiles will enable patient-specific analyses in higher throughput. PK-PD modelling already improved dose selection and characterization of drug effects on tumor growth, overall survival and safety [ 30 ], but requires relevant data for the patient and his/her tumor.…”
Section: Discussionmentioning
confidence: 99%
“…Since classical microdialysis already allowed insights into tissue-specific drug [ 28 ] and cytokine levels [ 29 ], the automated determination of pharmacokinetic profiles will enable patient-specific analyses in higher throughput. PK-PD modelling already improved dose selection and characterization of drug effects on tumor growth, overall survival and safety [ 30 ], but requires relevant data for the patient and his/her tumor.…”
Section: Discussionmentioning
confidence: 99%
“…Microdialysis is used both in clinical research in many organs including skin (percutaneous penetration, pharmacokinetics, skin metabolism, and skin inflammation) and in clinical monitoring in intensive care settings. 1 However, for optimal interpretation of the high-sensitivity microdialysis data obtained, normalization is required for blood tissue concentration and the degree of swelling (water content) in the target tissue. 2 Quantification of erythema is relatively easily achieved by non-invasive spectrophotometric techniques such as polarization spectroscopy or by use of an internal calibrator in the perfusate, but there is as yet no robust method for quantification of water in living tissue in real time.…”
Section: Introductionmentioning
confidence: 99%
“… 2 Quantification of erythema is relatively easily achieved by non-invasive spectrophotometric techniques such as polarization spectroscopy or by use of an internal calibrator in the perfusate, but there is as yet no robust method for quantification of water in living tissue in real time. 1 , 3 , 4 Our group is developing the use of spatial frequency domain spectroscopy (SFDS) to provide real-time data on tissue water content.…”
Section: Introductionmentioning
confidence: 99%
“…This paper summarises some of the achievements of 2019. Several EAACI Position Papers have been published in 2019 [5][6][7][8][9][10][11][12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%