Skin model surface temperatures during single and multiple cryogen spurts used in laser dermatologic surgery

Ramírez-San-Juan, J. C.; Aguilar, Guillermo; Tuqan, Alia T.; Kelly, Kristen M.; Nelson, J. Stuart

doi:10.1002/lsm.20124

Cited by 14 publications

(10 citation statements)

References 15 publications

(22 reference statements)

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“…Frost formation and the evaporation of the cryogen pool are associated with reduced optical penetration depth43,120 and thus subtherapeutic photocoagulation. Moreover, frost formation may result in overcooling of the skin and corollary (epi)dermal injury 38,77,119…”

Section: Hemodynamic Alterations In the Dermismentioning

confidence: 99%

An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains

et al. 2011

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During the last three decades, several laser systems, ancillary technologies, and treatment modalities have been developed for the treatment of port wine stains (PWSs). However, approximately half of the PWS patient population responds suboptimally to laser treatment. Consequently, novel treatment modalities and therapeutic techniques/strategies are required to improve PWS treatment efficacy. This overview therefore focuses on three distinct experimental approaches for the optimization of PWS laser treatment. The approaches are addressed from the perspective of mechanical engineering (the use of local hypobaric pressure to induce vasodilation in the laser-irradiated dermal microcirculation), optical engineering (laser-speckle imaging of post-treatment flow in laser-treated PWS skin), and biochemical engineering (light- and heat-activatable liposomal drug delivery systems to enhance the extent of post-irradiation vascular occlusion).

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Section: Hemodynamic Alterations In the Dermismentioning

confidence: 99%

An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains

et al. 2011

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“…The tip of a thermometer was directly exposed to the aerosol deodorant spray at a distance of 5 cm for about 30 s and a temperature of −20 °C was achieved. Adiabatic cooling is the physical modality during the use of aerosol spray leading to cryo‐injury when used prolonged 10,11 . This will occur with any sort of spray, independent of its contents.…”

Section: Discussionmentioning

confidence: 99%

Bullous cryothermic dermatitis artefacta induced by deodorant spray abuse

Jacobi¹,

Bender

Hertl

et al. 2010

Acad Dermatol Venereol

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“…This was later confirmed also by Franco et al [163] in terms of the uniformity in the protection these sprays could provide when used in conjunction with laser irradiation. Nevertheless, the reader must not forget that non-uniformities in the heat transfer coefficient over the entire spray area exist and depend on the following parameters: geometric parameters such as nozzle diameter-length [164], nozzle-to-skin distance [165] and nozzle angle [162], cryogen spurt duration [166][167][168][169][170][171][172][173], ambient pressure [174][175][176], humidity and frost formation effects [177][178][179][180], skin indentation effects [181,182], and the dynamics of cryogen spray deposition, such as cryogenic spray shape, the droplet velocity and diameter [183]. 3.…”

Section: Physical Model and Mathematical Formulationmentioning

confidence: 99%

Numerical Prediction of the Intracellular ICE Formation Zone during Cryosurgery on a Nodular Basal Cell Carcinoma Using Liquid Nitrogen Spray

Sun

Martı́nez-Suástegui

Wang

et al. 2012

International Journal of Spray and Combustion Dynamics

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Cryosurgery is a surgical technique that employs freezing to destroy target tumor tissue. While the main objective during a cryosurgical procedure is to ensure tissue destruction within the cryolesion, the greatest challenge is how to spare the surrounding healthy tissues from cryoablation. In this work, a historical review of the field of cryosurgery is presented followed by a theoretical study where a mathematical model is developed for cryosurgery on a basal cell carcinoma (BCC) using liquid nitrogen (LN 2 ) spray. The model takes into consideration the anatomic structure of skin tissue and the irregular geometry of BCC. In particular, a methodology for quantitatively determining the extent of the intracellular ice formation (IIF) zone based on the tissue temperature and cooling rate (CR) is proposed, which can directly relate to the necrosis of the cancer cells after cryosurgery. The model is then used to analyze formation of the IIF zone during cryosurgery on a BCC and quantification is provided for the volume of the final IIF zone. A parametric study is also carried out to investigate the effect of various protocol parameters on the final IIF zone. The results should be useful for dermatologists for pre-treatment surgery planning.

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Skin model surface temperatures during single and multiple cryogen spurts used in laser dermatologic surgery

Abstract: These results suggest that: (1) similar epidermal protection may be attained with SCS and MCS for Deltat(total)

Cited by 14 publications

References 15 publications

An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains

An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains

Bullous cryothermic dermatitis artefacta induced by deodorant spray abuse

Numerical Prediction of the Intracellular ICE Formation Zone during Cryosurgery on a Nodular Basal Cell Carcinoma Using Liquid Nitrogen Spray

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