Skin permeation of different steroid hormones from polymeric coated liposomal formulations

Biruss, Babette; Valenta, Claudia

doi:10.1016/j.ejpb.2005.08.004

Cited by 34 publications

(10 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, after 2.5 h, the percentage increases of drug release were 34.5% and 29.6% for DPPC liposomes and chitosan-coated liposomes respectively. Our results are in agreement with those of previous investigations into the effect of surface coating with polymers to preserve liposome stability [30][31][32]. The protective effect of hydrophilic polymer coating depends on the ability of the polymer to adhere to the lipid bilayers [29].…”

Section: Turbidity Measurementssupporting

confidence: 94%

Effect of chitosan coating on the characteristics of DPPC liposomes

Mady

Darwish

2010

Journal of Advanced Research

View full text Add to dashboard Cite

Because it is both biocompatible and biodegradable, chitosan has been used to provide a protective capsule in new drug formulations. The present work reports on investigations into some of the physicochemical properties of chitosan-coated liposomes, including drug release rate, transmission electron microscopy (TEM), zeta potential and turbidity measurement. It was found that chitosan increases liposome stability during drug release. The coating of DPPC liposomes with a chitosan layer was confirmed by electron microscopy and the zeta potential of liposomes. The coating of liposomes by chitosan resulted in a marginal increase in the size of the liposomes, adding a layer of (92 ± 27.1 nm). The liposomal zeta potential was found to be increasingly positive as chitosan concentration increased from 0.1% to 0.3% (w/v), before stabilising at a relatively constant value. Turbidity studies revealed that the coating of DPPC liposomes with chitosan did not significantly modify the main phase transition temperature of DPPC at examined chitosan concentrations. The appropriate combination of liposomal and chitosan characteristics may produce liposomes with specific, prolonged and controlled release.

show abstract

Section: Turbidity Measurementssupporting

confidence: 94%

Effect of chitosan coating on the characteristics of DPPC liposomes

Mady

Darwish

2010

Journal of Advanced Research

View full text Add to dashboard Cite

show abstract

“…It was reported that stability of the peptides were significantly improved by coating liposomes with a polymer such as polyethylene glycol (PEG). Furthermore, polymer coated carriers could improve the delivery of proteins and peptides to the skin by increasing dermal permeation as well as stability (Biruss and Valenta, 2006). The addition of silicon dioxide and a polymeric emulsifier (Pemulen TR1) enhanced skin permeability likely due to the opening effect on tight junctions in the skin (Valenta and Auner, 2004).…”

Section: Combination Of Carriersmentioning

confidence: 99%

Improvements in chemical carriers of proteins and peptides

Bolhassani

2019

Cell Biology International

View full text Add to dashboard Cite

The successful intracellular delivery of biologically active proteins and peptides plays an important role for therapeutic applications. Indeed, protein/peptide delivery could overcome some problems of gene therapy, for example, controlling the expression levels and the integration of transgene into the host cell genome. Thus, protein/peptide drug delivery showed a promising and safe approach for treatment of cancer and infectious diseases. Due to the unique physical and chemical properties of proteins, their production (e.g., isolation, purification & formulation) and delivery represented significant challenges in pharmaceutical studies. Modification in the structural moieties of these protein/peptide drugs could improve their solubility, stability, crystallinity, lipophilicity, enzymatic susceptibility and targetability, and subsequently, therapies and cures against various diseases. Using the structural modification of protein/peptide, their delivery provided overall higher success rates including high specificity, high activity, bioreactivity and safety. Recently, biotechnological and pharmaceutical companies have tried to find novel techniques for the modifications and improve delivery systems/carriers. However, each carrier has its own benefits and drawbacks, and an appropriate carrier is often established by the physicochemical properties of protein or peptide, the ideal route of injection, and clinical characteristics of therapy. In this review, an attempt was made to give an overview on the chemical carriers for proteins and peptides as well as the recent advances in this field.

show abstract

“…Ethosomes, lipid carriers composed mainly of phospholipids and alcohol, are interesting and innovative vesicular systems that have appeared in the field of pharmaceutical technology and drug delivery in recent years, since they are reported to possess significantly higher transdermal flux [8–12]. Ethosomes are similar in physical structure and form to liposomes, which are the more widely studied phospholipid vesicles [13–17]. However, ethosomes may have some advantages over liposomes, because ethosomes are easy to prepare, have high encapsulation efficiency for a wide range of molecules and are small relative to liposomes when neither vesicle type is subjected to size reduction steps such as sonication or extrusion [18, 19].…”

Section: Introductionmentioning

confidence: 99%

Size and CT density of iodine‐containing ethosomal vesicles obtained by membrane extrusion: Potential for use as CT contrast agents

Bomin

Choi

Kim

2013

Biotechnology Journal

View full text Add to dashboard Cite

Computed tomography (CT) is the primary non-invasive imaging technique used for most patients with suspected liver disease. In order to improve liver-specific imaging properties and prevent toxic effects in patients with compromised renal function, we investigated the encapsulation of iodine within ethosomal vesicles. As a first step in the development of novel contrast agents using ethosomes for CT imaging applications, iodine was entrapped within ethosomes and iodine-containing ethosomes of the desired size were obtained by extrusion using a polycarbonate membrane with a defined pore size. Ethosomes containing iodine showed a relatively high CT density, which decreased when they were extruded, due to the rupture and re-formation of the lipid bilayer of the ethosome. However, when a solution with a high iodine concentration was used as a dispersion media during the extrusion process, the decrease in CT density could be prevented. In addition, ethosomes containing iodine were taken up efficiently by macrophages, which are abundant in the liver, and these ethosomes exhibited no cellular toxicity. These results demonstrate that iodine could be entrapped within ethosomal vesicles, giving the ethosomes a relatively high CT density, and that the extrusion technique used in this study could conveniently and reproducibly produce ethosomal vesicles with a desired size. Therefore, ethosomes containing iodine, as prepared in this study, have potential as contrast agents with applications in CT imaging.

show abstract

Skin permeation of different steroid hormones from polymeric coated liposomal formulations

Cited by 34 publications

References 42 publications

Effect of chitosan coating on the characteristics of DPPC liposomes

Effect of chitosan coating on the characteristics of DPPC liposomes

Improvements in chemical carriers of proteins and peptides

Size and CT density of iodine‐containing ethosomal vesicles obtained by membrane extrusion: Potential for use as CT contrast agents

Contact Info

Product

Resources

About