1979
DOI: 10.1159/000250797
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Skin Petechiae and Ecchymoses (Vasculitis) Due to Anticoagulant Therapy

Abstract: The appearance of petechiae and ecchymoses following anticoagulant and fibrinolytic therapy is an unusual and rare complication. The mechanism of the vasculitis is obscure but may be related to a chemical vasotoxic reaction. During anticoagulant and fibrinolytic therapy, 6 patients developed petechiae and ecchymoses which was accompanied by pain and fever. There were no disturbances of blood clotting factors. In spite of the varied action of the different anticoagulants and fibrinolytic drugs, the clinical cou… Show more

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Cited by 12 publications
(2 citation statements)
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“…Scarification and intracutaneous skin challenge produce no reaction [3,6], Coumadin treatment induces several kinds of skin lesions [2], This study has brought evidence of an immunological involvement in a case of nonpruritic purpuric skin eruption. Of interest is the fact that the histolog ical features of coumadin-induced dermal gangrene [16][17][18][19], which is the most common dermatological complication, are consistent with leukocy toclastic vasculitis [6,20,21 ], a finding which suggests an immunological reaction.…”
Section: Commentmentioning
confidence: 74%
See 1 more Smart Citation
“…Scarification and intracutaneous skin challenge produce no reaction [3,6], Coumadin treatment induces several kinds of skin lesions [2], This study has brought evidence of an immunological involvement in a case of nonpruritic purpuric skin eruption. Of interest is the fact that the histolog ical features of coumadin-induced dermal gangrene [16][17][18][19], which is the most common dermatological complication, are consistent with leukocy toclastic vasculitis [6,20,21 ], a finding which suggests an immunological reaction.…”
Section: Commentmentioning
confidence: 74%
“…Among others, an immunological mechanism was suggested but remained unproven [3][4][5][6], Recently it was shown by Stavo-rovsky et al [6] that dermal gangrene following coumadin was the result of vasculitis.…”
Section: Introductionmentioning
confidence: 99%