Skin photoprotection improvement: Synergistic interaction between lipid nanoparticles and organic UV filters

Nikolic, Sasha; Keck, Cornelia M.; Anselmi, Cecilia; Müller, R.H.

doi:10.1016/j.ijpharm.2011.05.010

Cited by 90 publications

(60 citation statements)

References 32 publications

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“…[8][9][10] The SLNs are made of solid lipid material, which remains in the solid state at room temperature, protects the chemically labile drugs, and provides slow drug release to achieve controlled drug release profiles for prolonged time intervals. The lipid materials used for SLNs are biodegradable and biocompatible and provide better safety profile.…”

Section: Introductionmentioning

confidence: 99%

“…The lipid materials used for SLNs are biodegradable and biocompatible and provide better safety profile. 10,11 Nanostructured lipid carriers (NLCs) are the second generation of SLNs and offer many advantages over SLNs. The solid lipid, when used alone for preparing SLNs, forms a perfect crystal lattice with limited space for accommodating the drugs.…”

Section: Introductionmentioning

confidence: 99%

“…14,15 The occlusive effect exerted by NLCs can improve skin hydration and promote the penetration of drugs. 10 Additionally, drugs (such as 5-FU) may be encapsulated within the core so that the skin irritation reaction could be minimized following topical application.…”

Section: Introductionmentioning

confidence: 99%

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Development and evaluation of nanostructured lipid carrier-based hydrogel for topical delivery of 5-fluorouracil

Rajinikanth¹,

Chellian²

2016

IJN

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The aim of this study was to develop a nanostructured lipid carrier (NLC)-based hydrogel and study its potential for the topical delivery of 5-fluorouracil (5-FU). Precirol ® ATO 5 (glyceryl palmitostearate) and Labrasol ® were selected as the solid and liquid lipid phases, respectively. Poloxamer 188 and Solutol ® HS15 (polyoxyl-15-hydroxystearate) were selected as surfactants. The developed lipid formulations were dispersed in 1% Carbopol ® 934 (poly[acrylic acid]) gel medium in order to maintain the topical application consistency. The average size, zeta potential, and polydispersity index for the 5-FU-NLC were found to be 208.32±8.21 nm, −21.82±0.40 mV, and 0.352±0.060, respectively. Transmission electron microscopy study revealed that 5-FU-NLC was <200 nm in size, with a spherical shape. In vitro drug permeation studies showed a release pattern with initial burst followed by sustained release, and the rate of 5-FU permeation was significantly improved for 5-FU-NLC gel (10.27±1.82 μg/cm 2 /h) as compared with plain 5-FU gel (2.85±1.12 μg/cm 2 /h). Further, skin retention studies showed a significant retention of 5-FU from the NLC gel (91.256±4.56 μg/cm 2 ) as compared with that from the 5-FU plain gel (12.23±3.86 μg/cm 2 ) in the rat skin. Skin irritation was also significantly reduced with 5-FU-NLC gel as compared with 5-FU plain gel. These results show that the prepared 5-FU-loaded NLC has high potential to improve the penetration of 5-FU through the stratum corneum, with enormous retention and with minimal skin irritation, which is the prerequisite for topically applied formulations.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development and evaluation of nanostructured lipid carrier-based hydrogel for topical delivery of 5-fluorouracil

Rajinikanth¹,

Chellian²

2016

IJN

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“…They also have the potential to protect chemically labile active compounds against degradation [6,7]. In cosmetics, these properties make them a viable replacement of traditional formulations, and thus, they have been studied as encapsulation systems for various labile compounds, including sunscreen agents [8][9][10][11] and antioxidants [12,13].…”

Section: Introductionmentioning

confidence: 99%

Photostability enhancement by encapsulation of α-tocopherol into lipid-based nanoparticles loaded with a UV filter

Niculae

Lăcătuşu

Bors

et al. 2014

Comptes Rendus. Chimie

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“…The SLNs can act as physical sunscreens on their own, i.e. they have the ability to scatter or reflect incident UV radiation [31]. In this work, the SPF values were 22.0 ± 1.0, 27.3 ± 1.2, 19.7 ± 1.5, and 21.7 ± 1.2 (mean ± SD, n = 3) for formulations F1, F2, F3, and F4, respectively.…”

Section: Resultsmentioning

confidence: 99%

Development and Evaluation of Lipid Nanoparticles Containing Natural Botanical Oil for Sun Protection: Characterization and in vitro and in vivo Human Skin Permeation and Toxicity

Andréo-Filho

Bim

Kaneko

et al. 2017

Skin Pharmacol Physiol

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The use of sunscreen products is widely promoted by schools, government agencies, and health-related organizations to minimize sunburn and skin damage. In this study, we developed stable solid lipid nanoparticles (SLNs) containing the chemical UV filter octyl methoxycinnamate (OMC). In parallel, we produced similar stable SLNs in which 20% of the OMC content was replaced by the botanical urucum oil. When these SLNs were applied to the skin of human volunteers, no changes in fluorescence lifetimes or redox ratios of the endogenous skin fluorophores were seen, suggesting that the formulations did not induce toxic responses in the skin. Ex vivo (skin diffusion) tests showed no significant penetration. In vitro studies showed that when 20% of the OMC was replaced by urucum oil, there was no reduction in skin protection factor (SPF), suggesting that a decrease in the amount of chemical filter may be a viable alternative for an effective sunscreen, in combination with an antioxidant-rich vegetable oil, such as urucum. There is a strong trend towards increasing safety of sun protection products through reduction in the use of chemical UV filters. This work supports this approach by producing formulations with lower concentrations of OMC, while maintaining the SPF. Further investigations of SPF in vivo are needed to assess the suitability of these formulations for human use.

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Skin photoprotection improvement: Synergistic interaction between lipid nanoparticles and organic UV filters

Cited by 90 publications

References 32 publications

Development and evaluation of nanostructured lipid carrier-based hydrogel for topical delivery of 5-fluorouracil

Development and evaluation of nanostructured lipid carrier-based hydrogel for topical delivery of 5-fluorouracil

Photostability enhancement by encapsulation of α-tocopherol into lipid-based nanoparticles loaded with a UV filter

Development and Evaluation of Lipid Nanoparticles Containing Natural Botanical Oil for Sun Protection: Characterization and in vitro and in vivo Human Skin Permeation and Toxicity

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