Skin protection against ultraviolet induced free radicals with ascorbyl palmitate in microemulsions

Jurkovič, Polona; Šentjurc, Marjeta; Gašperlin, Mirjana; Kristl, Julijana; Pečar, Slavko

doi:10.1016/s0939-6411(03)00062-6

Cited by 54 publications

(44 citation statements)

References 21 publications

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“…Skin sampling was performed according to a modification of the procedure of Jurkovic et al [2003]. Skin samples were shaved, first rinsed in water, then three times in 125 mM aqueous KCl, dried, cut to obtain slices of 15 Â 10 Â 0.5 mm size, and kept on agar plates at 41C prior to irradiation.…”

Section: Preparation and Uv Irradiation Of Rat Skin Samplesmentioning

confidence: 99%

“…Despite these advantages of dry emulsions, they are still not popular in the cosmetic field or for topical applications where microemulsions or encapsulation of active agents, such as lipid or vitamin derivatives, are exclusively used [Jurkovic et al, 2003;Park and Kim, 2005]. In relation to a more general therapeutic purpose, the present studies were focused on developing stable sesamol-containing dry emulsions that retained high antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

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Development of spray‐ and freeze‐dried high‐concentration sesamol emulsions and antioxidant evaluation in fibroblasts and UV‐exposed rat skin slices

Alencar¹,

Gosset²,

Rahmouni³

et al. 2008

Drug Development Research

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Dry sesamol emulsions were synthesized from several combinations of saccharose with hydroxypropylmethylcellulose (HPMC) or sodium caseinate (SC) using spray-drying techniques at 1201 to 1801C, or freeze-drying. On the basis of physical characteristics such as droplet size distribution, residual moisture, and microscopic structure, the best material was obtained when spray-drying was applied at either 1501 or 1801C with SC or HPMC as excipients, respectively. The extent to which the antioxidant properties of free sesamol towards a set of free radicals (galvinoxyl, diphenylpicrylhydrazyl, superoxide, and hydroxyl) were altered in the starting and reconstituted liquid emulsions submitted to normal storage or pre-exposed to a flux hydroxyl radicals was investigated. Emulsions were further evaluated for their antioxidant properties in cultured 3T3 murine fibroblasts and in an ex vivo model of ultraviolet irradiated rat skin. It was found that, in the material having the best physical properties, encapsulation was decisive in: (1) improving the overall antioxidant behavior of reconstituted versus starting liquid emulsions: (2) sparing sesamol consumption due to free radical attack; and (3) significantly protecting cells and skin against free radical-or irradiation-induced enzymatic release and/or lipid peroxidation. Demonstrating a high activity at high dilutions where interactions of excipient become negligible, the new emulsions could be of great interest in sesamol-based pharmacology or topical applications. Drug Dev Res 69: 251-266, 2008.

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Section: Preparation and Uv Irradiation Of Rat Skin Samplesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of spray‐ and freeze‐dried high‐concentration sesamol emulsions and antioxidant evaluation in fibroblasts and UV‐exposed rat skin slices

Alencar¹,

Gosset²,

Rahmouni³

et al. 2008

Drug Development Research

View full text Add to dashboard Cite

show abstract

“…It is known [19] that UV irradiation of erythrocytes may result in the damage of the cell membranes with hemoglobin release, as well as in oxidation of oxyhemoglobin to methemoglobin. According to [20], the oxidation of the heme iron to trivalent state may be mediated, for instance, by peroxide species, which, in turn, may be formed in the system as a result of irradiation [21][22][23][24]. Figure 22.4, curves 1 and 2, gives the UV−Vis spectra of the antioxidants-free erythrocytes suspensions before and after irradiation.…”

Section: Antioxidant Properties Of the Nanocompositesmentioning

confidence: 99%

Supramolecular Complex Antioxidant Consisting of Vitamins C, E and Hydrophilic–Hydrophobic Silica Nanoparticles

Лагута

Kuzema

Stavinskaya

et al. 2009

Nanomaterials and Supramolecular Structures

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Samples with varied amount of surface trimethylsilyl groups were obtained via gas-phase chemical modification of silica nanoparticles. The biocompatibility tests conducted in erythrocyte suspension have shown that hydrophobization of silica decreases its damaging effect to the cells. Being wettable in aqueous media, partially silylated silicas have higher affinity to hydrophobic bioactive molecules in comparison with the initial silica. Novel antioxidant consisting of vitamins C and E and silica with 40% of surface trimethylsilyl groups was formulated. It was found that supramolecular complexes are formed on the silica surface due to the affinity of water-and fat-soluble antioxidants to hydrophilic silanol and hydrophobic trimethylsilyl groups, respectively. Test reactions (total phenolic index determination, DPPH test) and in vitro studies (spectral analysis of erythrocyte suspensions undergoing UV irradiation) revealed the correlation between antioxidant activity of the complex antioxidant and the vitamins' content. The antioxidant remained active during long-term storage under standard conditions.

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“…Moreover, a diverse range of drug molecules such as ketoprofen, apomorphine, estradiol, lidocaine [94 -97] , indomethacin and diclofenac [98] , prostaglandin E 1 [99] , aceclofenac [100] , vinpocetine [101] , azelaic acid [102] , methotrexate [103] , piroxicam [104] , triptolide [105] , fl uconazol [106] , and ascorbyl palmitate [107] were incorporated into different ME systems.…”

Section: Transdermal Drug Deliverymentioning

confidence: 99%

Microemulsions as Drug Delivery Systems

Alany

Wen

2007

Pharmaceutical Manufacturing Handbook

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Skin protection against ultraviolet induced free radicals with ascorbyl palmitate in microemulsions

Cited by 54 publications

References 21 publications

Development of spray‐ and freeze‐dried high‐concentration sesamol emulsions and antioxidant evaluation in fibroblasts and UV‐exposed rat skin slices

Development of spray‐ and freeze‐dried high‐concentration sesamol emulsions and antioxidant evaluation in fibroblasts and UV‐exposed rat skin slices

Supramolecular Complex Antioxidant Consisting of Vitamins C, E and Hydrophilic–Hydrophobic Silica Nanoparticles

Microemulsions as Drug Delivery Systems

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