Skin rash, headache and abnormal behaviour: unusual presentation of intracranial haemorrhage in dengue fever

Wani, Abdul Majid; Mejally, Mousa Ali Al; Hussain, Waleed Mohd; Maimani, Wail Al; Hanif, Sadia; Khoujah, Amer Mohd; Siddiqi, Ahmad; Akhtar, Mubeena; Bafaraj, Mazen G; Fareed, Khurram

doi:10.1136/bcr.06.2009.1949

Cited by 10 publications

(12 citation statements)

References 6 publications

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“…The presenting complaints in other reports are summarized in Table 1 as well. [ 16 17 18 19 20 21 22 23 24 25 26 27 ] Overall, fever, reduced or altered consciousness, vomiting, and headache are the top complaints. Three of the patients had shock of which two died.…”

Section: Results Of Other Case Reports and Seriesmentioning

confidence: 99%

Deadly intracranial bleed in patients with dengue fever: A series of nine patients and review of literature

Sam

Gee

Nasser

2016

Journal of Neurosciences in Rural Practice

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Introduction:Dengue fever is a global pandemic threat with increasing incidence. To date, there are no cures and the effectiveness of dengue vaccines is still uncertain. World Heath Organization introduced expanded dengue syndrome to include unusual presentations of dengue fever including severe neurologic complications. One of the deadly complications is intracranial hemorrhage (ICH).Methodology:We collected data of patients with ICH diagnosed via a plain computed tomography of the brain (CT brain) with thrombocytopenia and positive Dengue virus type 1 nonstructural protein (NS1) antigen test or positive dengue serology IgM from January 2014 till June 2015 at our center. Nine patients were included and all 20 other remaining patients reported in literature so far are discussed.Discussion:We found that all patients in our center requiring neurosurgical intervention died. Another interesting observation is that detection of Dengue IgG usually meant more severe ICH and poorer outcomes. From our series, platelet levels did not seem to influence the outcome.Conclusion:We recommend that for early detection of ICH, Dengue IgG should be routinely screened and a high index of suspicion be maintained. Future research should be focused on determining predictors of ICH in patients with dengue fever so that preventive steps can be taken as mortality is high and no treatment seems beneficial at the moment once severe ICH occurs.

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Section: Results Of Other Case Reports and Seriesmentioning

confidence: 99%

Deadly intracranial bleed in patients with dengue fever: A series of nine patients and review of literature

Sam

Gee

Nasser

2016

Journal of Neurosciences in Rural Practice

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“…A literature review of case reports as well as series describing demographic and clinical profile including the outcome of ICH in patients with DF are listed in Tables 1 and 2 , respectively. [ 3 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 ] Presence of fever, reduced or altered consciousness, vomiting, seizures, and headache are common chief complaints in patients with ICH. The occurrence of ICH associated with DF can be localized or diffuse involving commonly cerebrum, ventricles, and less commonly cerebellum.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous intracranial hemorrhage associated with dengue fever: An emerging concern for general physicians

Singh

Balasubramanian

Gupta

2018

J Family Med Prim Care

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Dengue fever (DF) is an arboviral disease caused by a positive-sense RNA virus of the genus Flavivirus. The overall incidence of DF has increased exponentially worldwide over the last three decades. The atypical clinical manifestations of DF grouped under expanded dengue syndrome (EDS), have also been reported more frequently for the last decade. These unusual manifestations are usually associated with coinfections, comorbidities, or complications of prolonged shock. Intracranial hemorrhage (ICH) is one of the rare manifestations of the central nervous system involvement by dengue as a part of EDS. The pathogenesis and treatment of this manifestation also remain controversial. Therefore, we report a case of a previously healthy 65-year-old female who developed ICH as a part of EDS along with a brief review of literature.

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“…Minor epistaxis, gum bleeding, and gastrointestinal bleeding are sometimes observed in children without shock (Carlos et al, 2005), but bleeding from mucosal surfaces tends to be both more common and more severe in adult. Intracranial hemorrhage is a very rare but often fatal complication (Wani et al, 2010).…”

Section: Hemorrhagic Manifestationmentioning

confidence: 99%

Dengue Virus

Murugesan¹,

Mythreyee²

2020

Emerging and Reemerging Viral Pathogens

108

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At some point in the past 2000À4000 years, DENVs moved out of the Asian jungle and into rural villages, where they were, and still are, transmitted to humans by peridomestic mosquitoes such as A. albopictus. Migration of people and commerce ultimately moved the viruses into larger villages, towns, and cities of tropical Asia, where the viruses were most likely transmitted sporadically by A. albopictus and possibly other closely related peridomestic Stegomyia species (Halstead, 2007). The slave trade and the resulting commerce were responsible for the introduction and the widespread distribution of an African mosquito, 284 16. DENGUE VIRUS EMERGING AND REEMERGING VIRAL PATHOGENS 288 16. DENGUE VIRUS EMERGING AND REEMERGING VIRAL PATHOGENS 292 16. DENGUE VIRUS EMERGING AND REEMERGING VIRAL PATHOGENS 294 16. DENGUE VIRUS EMERGING AND REEMERGING VIRAL PATHOGENS 296 16. DENGUE VIRUS EMERGING AND REEMERGING VIRAL PATHOGENS 298 16. DENGUE VIRUS EMERGING AND REEMERGING VIRAL PATHOGENS

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Skin rash, headache and abnormal behaviour: unusual presentation of intracranial haemorrhage in dengue fever

Cited by 10 publications

References 6 publications

Deadly intracranial bleed in patients with dengue fever: A series of nine patients and review of literature

Deadly intracranial bleed in patients with dengue fever: A series of nine patients and review of literature

Spontaneous intracranial hemorrhage associated with dengue fever: An emerging concern for general physicians

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